Are we Making Progress in Preventing and Treating MOF?

  • Arthur E. Baue


We like to think that we are improving the care of injured and operated patients so more patients survive and recover.1 Certainly regional trauma centers, better monitoring and intensive care, new drugs, improved operative surgery, and minimal surgical procedures have improved the possibilities of survival of our patients.2 During an era in which “evidence-based medicine”3 and “evidence-based research”4 are stressed, can we document objectively such improvements in patient care if they truly have occurred? Prospective, randomized, double-blind clinical trials are required to document the efficacy of various therapeutic efforts. Unfortunately, many, if not all, such studies of a single “magic bullet” have been negative.5 It is difficult to measure and document whether general resuscitation, operations, and intensive care have made an impact on survival and well-being. Controlled randomized trials are not possible. What would be the variable? Randomized to what?


Trauma Patient Systemic Inflammatory Response Syndrome Acute Respiratory Distress Syndrome Injury Severity Score Multiple Organ Failure 
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© Springer Science+Business Media New York 2000

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  • Arthur E. Baue

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