Abstract
Traumatic brain injury accounts for approximately 52,000 deaths each year in the United States. The incidence of severe head injury (SHI) is about 10–50 per 100,000 population.1 Although SHI accounts for only about 10% of all head injuries, it is still one of the most common entities seen in neurosurgical practice. Historically, SHI has been a black box of uncertain outcome, generating medical frustration.
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Ullman, J.S., Sin, A.H. (2000). Central Nervous System Failure: Neurotrauma Trials. In: Baue, A.E., Faist, E., Fry, D.E. (eds) Multiple Organ Failure. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1222-5_40
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