Immunomodulation of Cell-Mediated Responses: Is It Feasible?

  • Eugen Faist
  • M. W. Wichmann

Abstract

We know that the endogenous provisions of the organism to survive after major trauma are not sufficient and require exogenous support. Immunomodulatory strategies should prevent the conversion from systemic inflammatory response syndrome (SIRS) to bacterial sepsis and septic shock. Several strategies have been evaluated, including the blockade of mediators, particularly if their levels or effects become excessive and threaten the individual. Clinical trials with anti-tumor necrosis factor (TNF) antibodies, soluble TNF receptors, interleukin-1 (IL-1) receptor antagonists, and anti-lipopolysac-charide (LPS) monoclonal antibodies have been carried out, but no significant treatment benefit was observed.

Keywords

Morphine Testosterone Prostaglandin Neutropenia Thrombin 

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© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Eugen Faist
  • M. W. Wichmann

There are no affiliations available

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