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Metabolic Depletion and Failure: Muscle Cachexia During Injury and Sepsis

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Multiple Organ Failure

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Abstract

Severe injury and sepsis are associated with metabolic changes in virtually all organs and tissues and include alterations in carbohydrate, lipid, and protein metabolism.1,2 One of the most prominent metabolic consequences of critical illness is the catabolic response in skeletal muscle. Metabolic depletion and failure in skeletal muscle result in muscle atrophy, weakness, and fatigue, preventing ambulation and delaying recovery in these patients. When respiratory muscles are involved in the catabolic response3, difficulties arise when weaning the patient from the ventilator. In addition, muscle weakness increases the risk for aspiration and pneumonia.

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Authors
  1. Timothy A. Pritts
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  2. David R. Fischer
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  3. Per-Olof Hasselgren
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Editors and Affiliations

  1. Department of Surgery, St. Louis University Hospital, St. Louis, Missouri, 63110, USA

    Arthur E. Baue MD (Professor Emeritus) (Professor Emeritus)

  2. Department of Surgery, Klinikum Grosshadern, University of Munich, Munich, D-81377, Germany

    Eugen Faist MD (Professor) (Professor)

  3. Department of Surgery, School of Medicine, University of New Mexico, Albuquerque, New Mexico, 87131, USA

    Donald E. Fry MD (Professor and Chairman) (Professor and Chairman)

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Pritts, T.A., Fischer, D.R., Hasselgren, PO. (2000). Metabolic Depletion and Failure: Muscle Cachexia During Injury and Sepsis. In: Baue, A.E., Faist, E., Fry, D.E. (eds) Multiple Organ Failure. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1222-5_38

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  • DOI: https://doi.org/10.1007/978-1-4612-1222-5_38

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