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Modulation of the Hypermetabolic Response After Trauma and Burns

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Multiple Organ Failure

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Abstract

A hypermetabolic physiologic response characterizes the human response to major trauma.The complex process of maintaining homeostasis can be upset by a variety of perturbations. As the pathways and mechanisms begin to be understood, it is possible to think of modulating them under conditions of stress due to burn or blunt trauma to eliminate the deleterious components and restore the organism to a more normal state quickly. This possibility was recognized initially by Guthbertson,1 who identified the stress response after traumatic injuries that resulted in a period of negative nitrogen balance. Building on this foundation is the idea that manipulations can be done clinically to limit the deleterious effects of the systemic response to inflammatory mediators.

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Authors
  1. Art Sanford
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  2. David N. Herndon
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Editors and Affiliations

  1. Department of Surgery, St. Louis University Hospital, St. Louis, Missouri, 63110, USA

    Arthur E. Baue MD (Professor Emeritus) (Professor Emeritus)

  2. Department of Surgery, Klinikum Grosshadern, University of Munich, Munich, D-81377, Germany

    Eugen Faist MD (Professor) (Professor)

  3. Department of Surgery, School of Medicine, University of New Mexico, Albuquerque, New Mexico, 87131, USA

    Donald E. Fry MD (Professor and Chairman) (Professor and Chairman)

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Sanford, A., Herndon, D.N. (2000). Modulation of the Hypermetabolic Response After Trauma and Burns. In: Baue, A.E., Faist, E., Fry, D.E. (eds) Multiple Organ Failure. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1222-5_33

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  • DOI: https://doi.org/10.1007/978-1-4612-1222-5_33

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