Effects of Recombinant Human Growth Hormone on Body Composition and Metabolism in HIV-Associated Wasting

  • K. Mulligan
  • C. Grunfeld
  • M. K. Hellerstein
  • R. A. Neese
  • M. Schambelan
Conference paper
Part of the Serono Symposia USA book series (SERONOSYMP)


Body wasting is a frequent and potentially devastating accompaniment to infection with human immunodeficiency virus (HIV). Wasting can impair functional performance, immune function, and quality of life and is a factor in survival itself (1, 2). In many patients infected with HIV, death occurs when body cell mass (BCM) is depleted below a level that is critical to sustain life (1), implying that death in these patients may be due to malnutrition per se, rather than to the direct effects of infection and malignancy. The demonstrated associations between loss of body weight or BCM and survival imply that maintenance or restoration of weight or BCM could prolong life in HIV-infected persons (1). Thus, considerable effort has been directed to the search for effective anabolic therapies.


Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Rest Energy Expenditure Lean Tissue Endocrine Society 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • K. Mulligan
  • C. Grunfeld
  • M. K. Hellerstein
  • R. A. Neese
  • M. Schambelan

There are no affiliations available

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