Insulin-Like Growth Factors and Skeletal Remodeling

  • Julie Patterson
  • Jay R. Shapiro
  • Marc R. Blackman
Conference paper
Part of the Serono Symposia USA book series (SERONOSYMP)


Research during the past several years has afforded considerable insight into the integrated system of hormones, cytokines, and locally acting growth factors that regulate the differentiation of bone cell precursors and modulate bone cell activity. Insulin-like growth factor I (IGF-I) is a peptide synthesized by the osteoblast that plays a key role in skeletal extracellular matrix synthesis (1). IGF-II, also synthesized by the osteoblast, has similar effects on osteoblast differentiation, but is less potent as regards protein synthesis (2). The osteoblast, via its synthesis of various other growth factors and cytokines, subserves autocrine and paracrine functions that coordinate and mediate the metabolic activities of bone marrow stromal cells, cells of the monocyte-macrophage series, bone lining cells, and osteoclasts (3). This chapter discusses the synthesis of IGFs by bone cells and the metabolic actions of IGF-I on osteoblasts and their precursors and presents recent data describing the effect of recombinant human IGF-I (rhIGF-I) on skeletal turnover in postmenopausal women.


Skeletal Remodel Bone Cell Precursor Cancellous Bone Strength Bone Matrix Apposition Hypopituitary Dwarf Mouse 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Julie Patterson
  • Jay R. Shapiro
  • Marc R. Blackman

There are no affiliations available

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