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Role of Somatostatin in the Regulation of Growth Hormone Secretion

  • Conference paper
Book cover GHRH, GH, and IGF-I

Part of the book series: Serono Symposia USA ((SERONOSYMP))

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Abstract

The first report detailing the chemical structure of somatostatin (somatotropin release inhibiting factor [SRIF]) was published 20 years ago by Paul Brazeau and collaborators working in Roger Guillemin’s laboratory (1). Brazeau, then a postdoctoral fellow, had been assigned the task of isolating growth hormone (GH) releasing factor from extracts of sheep hypothalami, using as his bioassay the release of GH from rat pituitaries incubated in vitro. However, the dominant GH regulatory substance in the extracts was an inhibitor, and the group undertook to isolate somatostatin instead. In retrospect, there was adequate reason to suspect the existence of a GH release inhibitory factor: Krulich, Dhariwal, and McCann had previously reported that rat hypothalamic extracts had stimulatory or inhibitory effects on GH secretion (depending on the region extracted) and had postulated the existence of a dual control system of GH regulation (2), at that time a novel concept of hypothalamic-pituitary control.

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References

  1. Brazeau P, Vale WW, Burgus R, et al. Hypothalamic peptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 1973;179: 77–9.

    Article  PubMed  CAS  Google Scholar 

  2. Krulich L, Dhariwal APS, McCann SM. Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro. Endocrinology 1968;83:783–90.

    Article  PubMed  CAS  Google Scholar 

  3. Reichlin S. Somatostatin. N Engl J Med 1983;309:1495–501;1556–63.

    Article  PubMed  CAS  Google Scholar 

  4. Patel Y. Somatostatin. In: Weill C, Müller EE, Thorner MO, eds. Basic and clinical aspects of neuroscience; vol 4. Berlin: Springer-Verlag, 1992: 1–16.

    Google Scholar 

  5. Reichlin S, ed. Somatostatin: basic and clinical status. New York: Plenum Press, 1987.

    Google Scholar 

  6. Patel YC, Tannenbaum GS, eds. Somatostatin: basic and clinical aspects. Metabolism 1990;(suppl 2).

    Google Scholar 

  7. Tannenbaum GS, Ling N. The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion. Endocrinology 1984;115:1952–7.

    Article  PubMed  CAS  Google Scholar 

  8. Plotsky PM, Vale W. Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science 1985;230:461–3.

    Article  PubMed  CAS  Google Scholar 

  9. Tannenbaum GS, Painson JC, Lapointe M, et al. Interplay of somatostatin and growth hormone-releasing hormone in genesis of episodic growth hormone secretion. Metabolism 1990;39(suppl 2):35–9.

    Article  PubMed  CAS  Google Scholar 

  10. Frohman LA, Dows TR, Clarke IJ, Thomas GB. Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep. J Clin Invest 1990;86:17–24.

    Article  PubMed  CAS  Google Scholar 

  11. Zeitler P, Tannenbaum GS, Clifton DK, Steiner RA. Ultradian oscillations in Somatostatin and growth hormone-releasing hormone mRNAs in the brains of adult male rats. Proc Natl Acad Sci USA 1991;88:8920–4. Erratum 1992; 89:1997.

    Article  PubMed  CAS  Google Scholar 

  12. Vance ML, Kaiser DL, Evans WS, et al. Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of human growth hormone releasing factor (1–40). J Clin Invest 1985;75:1584–90.

    CAS  Google Scholar 

  13. Krisch B. Immunohistochemical results on the distribution of somatostatin in the hypothalamus and in limbic structures of the rat. J Histochem Cytochem 1979;27:1389–90.

    Article  PubMed  CAS  Google Scholar 

  14. Liposits ZS, Merchenthaler I, Paull WK, Flerko B. Synaptic communication between somatostatinergic axons and growth hormone-releasing factor (GRF) synthesizing neurons in the arcuate nucleus of the rat. Histochemistry 1988; 89:247–52.

    Article  PubMed  CAS  Google Scholar 

  15. Bertherat J, Dournaud P, Berod A, et al. Growth hormone-releasing hormone-synthesizing neurons are a subpopulation of somatostatin receptor‑labelled cells in the rat arcuate nucleus: a combined in situ hybridization and receptor light-microscopic radioautographic study. Neuroendocrinology 1992; 56:25–31.

    Article  PubMed  CAS  Google Scholar 

  16. McCarthy GF, Beaudet A, Tannenbaum GS. Colocalization of somatostatin receptors and growth hormone-releasing factor immunoreactivity in neurons of the rat arcuate nucleus. Neuroendocrinology 1992;56:18–24.

    Article  PubMed  CAS  Google Scholar 

  17. Burton K-SA, Kabigting EB, Clifton DK, Steiner RA. Growth hormone receptor messenger ribonucleic acid distribution in the adult male rat brain and its colocalization in hypothalamic somatostatin neurons. Endocrinology 1992;131:958–63.

    Article  PubMed  CAS  Google Scholar 

  18. Mitsugi N, Arita J, Kimura F. Effects of intracerebroventricular administration of growth hormone-releasing factor and corticotropin-releasing factor on somatostatin secretion into rat hypophysial blood. Neuroendocrinology 1990;51:93–6.

    Article  PubMed  CAS  Google Scholar 

  19. Berelowitz M, Szabo M, Frohman LA, et al. Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science 1981;212:1279–81.

    Article  PubMed  CAS  Google Scholar 

  20. Bertherat J, Timsit J, Bluet-Pajot M-T, et al. Chronic GH hypersecretion induces reciprocal and reversible changes in mRNA levels from hypothalamic GH-releasing hormone and somatostatin neurons in the rat. J Clin Invest 1993;91:1791–3.

    Article  Google Scholar 

  21. Reichlin S. Somatostatin. In: Krieger DM, Brownstein M, Martin JB, eds. Brain peptides. New York: Wiley and Sons, 1983:711–52.

    Google Scholar 

  22. Müller EE. Some aspects of the neurotransmitter control of anterior pituitary function. Pharmacol Res 1989;21:75–85.

    Article  PubMed  Google Scholar 

  23. Richardson SB, Hollander CS, D’Eletto R, et al. Acetylcholine inhibits the release of somatostatin from rat hypothalamus in vitro. Endocrinology 1980;107:122–9.

    Article  PubMed  CAS  Google Scholar 

  24. Robbins RJ, Sutton RE, Reichlin S. Effects of neurotransmitters and cyclic AMP on somatostatin release from cultured cerebral cortical cells. Brain Res 1982;234:377–86.

    Article  PubMed  CAS  Google Scholar 

  25. Peterfreund RA, Vale WW. Muscarinic cholinergic stimulation of somatostatin secretion from long term dispersed cell cultures of fetal rat hypothalamus: inhibition by gamma-aminobutyric acid and serotonin. Endocrinology 1983;112:526–34.

    Article  PubMed  CAS  Google Scholar 

  26. Panzeri G, Torsello A, Cella A, et al. Age-related modulatory activity by a cholinergic agonist on the growth hormone response to GH-releasing hormone in the rat. Proc Soc Exp Biol Med 1990;193:301–5.

    PubMed  CAS  Google Scholar 

  27. Müller EE, Cella SG, De Gennaro CV. Aspects of the neuroendocrine control of growth hormone secretion in aging mammals. J Reprod Fertil 1993;(suppl 46):99–114.

    Google Scholar 

  28. Page MD, Koppeschaar HP, Dieguez C, et al. Cholinergic muscarinic receptor blockade with pirenzepine abolishes slow wave sleep-related growth hormone release in young patients with insulin-dependent diabetes mellitus. Clin Endocrinol 1987;26:355–9.

    Article  CAS  Google Scholar 

  29. Page MD, Bevan JS, Dieguez C, et al. Cholinergic blockade with pirenzepine improves carbohydrate tolerance and abolishes the GH response to meals in normal subjects. Clin Endocrinol 1989;30:519–24.

    Article  CAS  Google Scholar 

  30. Massara F, Ghigo E, Goffi S, et al. Blockade of hp-GRF-40-induced GH release in normal men by a cholinergic muscarinic antagonist. J Clin Endocrinol Metab 1984;59:1025–6.

    Article  PubMed  CAS  Google Scholar 

  31. Delitala G, Palermo M, Ross R, et al. Dopaminergic and cholinergic influences on the growth hormone response to growth hormone-releasing hormone in man. Neuroendocrinology 1987;45:243–7.

    Article  PubMed  CAS  Google Scholar 

  32. Ismail IS, Scanlon MF, Peters JR. Cholinergic control of growth hormone (GHBN) responses to GH-releasing hormone in insulin dependent diabetics: evidence for attenuated hypothalamic somatostatinergic tone and decreased GH autofeedback. Clin Endocrinol 1993;38:149–57.

    Article  CAS  Google Scholar 

  33. Cordido F, Dieguez C, Casanueva FF. Effect of central cholinergic neurotransmission enhancement by pyridostigmine on the growth hormone secretion elicited by clonidine, arginine, or hypoglycemia in normal and obese subjects. J Clin Endocrinol Metab 1990;70:1361–70.

    Article  PubMed  CAS  Google Scholar 

  34. Kelijman M, Frohman LA. The role of the cholinergic pathway in growth hormone feedback. J Clin Endocrinol Metab 1991;72:1081–7.

    Article  PubMed  CAS  Google Scholar 

  35. Giusti M, Marini G, Sessarego P, et al. Effect of cholinergic tone on growth hormone-releasing hormone-induced secretion of growth hormone in normal aging. Aging 1992;4:231–7.

    PubMed  CAS  Google Scholar 

  36. Coiro V, Volpi R, Bertoni P, et al. Effect of potentiation of cholinergic tone by pyridostigmine on the GH response to GHRH in elderly men. Gerontology 1992;38:217–22.

    Article  PubMed  CAS  Google Scholar 

  37. Raskind MA, Peskind ER, Veith RC. Differential effects of aging on neuroendocrine responses to physostigmine in normal men. J Clin Endocrinol Metab 1990;70:1420–5.

    Article  PubMed  CAS  Google Scholar 

  38. Carmeliet P, Denef C. Synthesis and release of acetylcholine by normal and tumoral pituitary corticotrophs. Endocrinology 1989;124:2218–27.

    Article  PubMed  CAS  Google Scholar 

  39. Carmeliet P, Denef C. Immunocytochemical and pharmacological evidence for an intrinsic cholinomimetic system modulating prolactin and growth hormone release in rat pituitary. Endocrinology 1988;123:1128–39.

    Article  PubMed  CAS  Google Scholar 

  40. Hisano S, Daikoku S. Existence of mutual synaptic relations between corticotropin-releasing factor-containing and somatostatin-containing neurons in the rat hypothalamus. Brain Res 1991;545:265–75.

    Article  PubMed  CAS  Google Scholar 

  41. Payne LC, Obal F Jr, Opp MR, Krueger JM. Stimulation and inhibition of growth hormone secretion by interleukin-lb: the involvement of growth hormone-releasing hormone. Neuroendocrinology 1992;56:118–23.

    Article  PubMed  CAS  Google Scholar 

  42. Kasting NW, Martin JB. Altered release of growth hormone and thyrotropin induced by endotoxin in the rat. Am J Physiol 1982;243:E332–3.

    PubMed  CAS  Google Scholar 

  43. Scarborough DE, Lee SL, Dinarello CA, Reichlin S. Interleukin-1 stimulates somatostatin biosynthesis in primary cultures of fetal rat brain. Endocrinology 1989;124:549–51. Erratum 124:2022.

    Article  PubMed  CAS  Google Scholar 

  44. Scarborough DE, Simar MR. Interleukin-lb stimulates somatostatin synthesis in astrocyte subcultures derived from neonatal rat brain [Abstract 1278]. Prog 73rd annu meet Endocr Soc, Washington, DC, 1991.

    Google Scholar 

  45. Montminy MR, Gonzalez GA, Yamamoto KK. Characteristics of the cAMP response unit. Recent Prog Horm Res 1990;46:219–29.

    PubMed  CAS  Google Scholar 

  46. Corpas E, Harman SM, Blackman MR. Human growth hormone and human aging. Endocr Rev 1993;14:20–39.

    PubMed  CAS  Google Scholar 

  47. Shibasaki T, Shizume K, Nakahara M, et al. Age-related changes in plasma growth hormone response to growth hormone-releasing factor in man. J Clin Endocrinol Metab 1984;58:212–4.

    Article  PubMed  CAS  Google Scholar 

  48. Pavlov EP, Harman SM, Merriam GR, et al. Responses of growth hormone and somatomedin-C to GH-releasing hormone in healthy aging men. J Clin Endocrinol Metab 1986;62:595–600.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Seymour Reichlin
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Editors and Affiliations

  1. Division of Endocrinology and Metabolism Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA

    Marc R. Blackman M.D.

  2. Division of Geriatric Medicine and Gerontology Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA

    Jesse Roth M.D.  & Jay R. Shapiro M.D.  & 

  3. Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA

    S. Mitchell Harman M.D., Ph.D.

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© 1995 Springer Science+Business Media New York

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Reichlin, S. (1995). Role of Somatostatin in the Regulation of Growth Hormone Secretion. In: Blackman, M.R., Roth, J., Harman, S.M., Shapiro, J.R. (eds) GHRH, GH, and IGF-I. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-0807-5_2

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  • DOI: https://doi.org/10.1007/978-1-4612-0807-5_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6908-3

  • Online ISBN: 978-1-4612-0807-5

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