Abstract
The classic actions of GH and IGF-I involve direct and indirect stimulation of cell proliferation and somatic growth. This chapter, however, provides an overview of the nonanabolic and non-growth-promoting actions of GH and IGF-I. This brief overview highlights the issues to be dealt with in depth in the ensuing chapters. For many years growth hormone (GH) has been known to behave as a potent insulin antagonist. Although the mechanism for GH-induced insulin resistance probably involves postreceptor signaling pathways, the cellular site of this interaction remains elusive.
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Melmed, S. (1995). Overview of Growth Hormone and IGF-I Effects on Intermediary Metabolism and Bone. In: Blackman, M.R., Roth, J., Harman, S.M., Shapiro, J.R. (eds) GHRH, GH, and IGF-I. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-0807-5_16
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DOI: https://doi.org/10.1007/978-1-4612-0807-5_16
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