Physiology of the Growth Hormone Releasing Hormone-Somatostatin-Growth Hormone-Insulin-Like Growth Factor I Axis

  • Lawrence A. Frohman
Conference paper
Part of the Serono Symposia USA book series (SERONOSYMP)


The growth hormone (GH) releasing hormone (GHRH)-somatostatin (SRIH)-GH-insulin-like growth factor I (IGF-I) axis regulates many essential life processes, including growth and development and metabolic and reparative processes and influences numerous other physiologic activities, including reproduction and, possibly, aging. During the past several decades, our understanding of this axis has increased markedly as the various components of the axis have been identified, characterized, and synthesized and their regulation clarified from molecular to clinical levels. An overview of the axis, therefore, must consider the individual components and their interactions under normal and pathologic conditions, the consequences of disturbances in their regulation, and the potential impact of the clinical use of individual hormones and hormone analogs both in replacement therapy and as pharmacologic agents to achieve specific effects.


Growth Hormone Growth Hormone Release Growth Hormone mRNA Growth Hormone Binding Protein Individual Hormone 
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Copyright information

© Springer Science+Business Media New York 1995

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  • Lawrence A. Frohman

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