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Genetic Mapping and DNA Sequencing pp 39–48Cite as

Interference, Heterogeneity and Disease Gene Mapping

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Part of the book series: The IMA Volumes in Mathematics and its Applications ((IMA,volume 81))

Abstract

The Human Genome Project has had a major impact on genetic research over the past five years. The number of mapped genes is now over 3,000 compared with approximately 1,600 in 1989 (Human Gene Mapping 10, [5]) and only about 260 ten years before that (Human Gene Mapping 5, [4]). The realization that extensive variation could be detected in anonymous DNA segments (Botstein et al. [1]) greatly enhanced the potential for mapping by linkage analysis. Previously, linkage studies had depended on polymorphisms that could be detected in red blood cell antigens, proteins (revealed by electrophoresis and isoelectric focusing), and cytogenetic heteromorphisms.

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Author information

Authors and Affiliations

  1. Department of Biometry and Genetics, and Center for Molecular and Human Genetics, Louisiana State University Medical Center, New Orleans, Louisiana, 70112, USA

    Bronya Keats

Authors
  1. Bronya Keats
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Editor information

Editors and Affiliations

  1. Department of Statistics, University of California at Berkeley, Evans Hall 367, Berkeley, CA, 94720-3860, USA

    Terry Speed

  2. Department of Mathematics and Molecular Biology, University of Southern California, 1042 W. 36th Place, DRB 155, Los Angeles, CA, 90089-1113, USA

    Michael S. Waterman

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© 1996 Springer Science+Business Media New York

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Keats, B. (1996). Interference, Heterogeneity and Disease Gene Mapping. In: Speed, T., Waterman, M.S. (eds) Genetic Mapping and DNA Sequencing. The IMA Volumes in Mathematics and its Applications, vol 81. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-0751-1_3

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  • DOI: https://doi.org/10.1007/978-1-4612-0751-1_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6890-1

  • Online ISBN: 978-1-4612-0751-1

  • eBook Packages: Springer Book Archive

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