Skip to main content
SpringerLink
Log in

Role of Folate Binding Proteins in Folate Metabolism

  • Chapter
Pathology Reviews • 1990

  • 217 Accesses

Abstract

The essential role of folates in cellular biochemistry is well established, but the nature of the participation by folate-binding proteins has been disputed. This review will define folate-binding proteins and distinguish them from low-affinity, nonspecific folate binders and folate- dependent intracellular enzymes. We outline changes in plasma folate-binding proteins in various clinical states, review their postulated functions, detail the biochemistry of mammalian soluble folate-binding proteins and their membrane-bound immunologically cross-reactive possible precursors, and present evidence that the latter proteins may function as the physiologic folate receptors and intracellular regulators of folate coenzyme availability.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Antony AC, Bruno E, Briddell RA, Brandt JE, Verma RS, Hoffman R: Effect of perturbation of specific folate receptors during erythropoiesis. J Clin Invest 80:1617, 1987

    Google Scholar 

  2. Antony AC, Kane MA, Kolhouse JF: Identification and characterization of a human erythrocyte membrane folate receptor (abstr). Clin Res 33:33, 1985

    Google Scholar 

  3. Antony AC, Kane MA, Portillo RM, Elwood PC, Kolhouse JF: Studies of the role of a participate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells. J Biol Chem 260:14911, 1985

    PubMed  CAS  Google Scholar 

  4. Antony AC, Utley CS, Marcell PD, Kolhouse JF: Isolation, characterization and comparison of the solubilized particulate and soluble folate binding proteins from human milk. J Biol Chem 257:10081, 1982

    PubMed  CAS  Google Scholar 

  5. Antony AC, Utley CS, Van Horne KC, Kolhouse JF: Isolation and characterization of a folate receptor from human placenta. J Biol Chem 256:9684, 1981

    PubMed  CAS  Google Scholar 

  6. Areelkul S, Yamarat P, Vongyuthithum M: Folic acid and folate binding protein in pregnancy. J Nutr Sci Vitaminol 23:447, 1977

    Google Scholar 

  7. Beck WS: Megaloblastic anemias II. Folic acid deficiency. In Hematology, edited by Beck WS, p 101. Cambridge, MA, MIT Press, 1977

    Google Scholar 

  8. Benesch R, Waxman S, Benesch R, Baugh C: The binding of folyl polyglutamates by hemoglobin. Biochem Biophys Res Commun 106:1359, 1982

    PubMed  CAS  Google Scholar 

  9. Chabner BA: Methotrexate. In Pharmacologic Principles of Cancer Treatment, edited by Chabner B, p 229. Philadelphia, W B Saunders, 1982

    Google Scholar 

  10. Chen C, Wagner C: Folate transport in the choroid plexus. Life Sci 16:1571, 1975

    PubMed  CAS  Google Scholar 

  11. Colman N, Herbert V: Folate binding proteins. Annu Rev Med 31:433, 1980

    PubMed  CAS  Google Scholar 

  12. Colman N, Hettiarachchy N, Herbert V: Detection of a milk factor that facilitates folate uptake by intestinal cells. Science 211:1427, 1981

    PubMed  CAS  Google Scholar 

  13. Cook RJ, Wagner C: Measurement of a folate binding protein from rat liver cytosol by radioimmunoassay. Arch Biochem Biophys 208:358, 1981

    PubMed  CAS  Google Scholar 

  14. Cook RJ, Wagner C: Purification and partial characterization of rat liver folate binding protein. Biochemistry 21:4427, 1982

    PubMed  CAS  Google Scholar 

  15. Cook RJ, Wagner C: Glycine N-methyltransferase is a folate binding protein of rat liver cytosol. Proc Natl Acad Sci USA 81:3631, 1984

    PubMed  CAS  Google Scholar 

  16. Corrocher R, Abramson RG, King VK, Schreiber C, Dikman S, Waxman S: Differential binding of rat renal cortex brush border and basolateral membrane preparations. Proc Soc Exp Biol med 178:73, 1985

    PubMed  CAS  Google Scholar 

  17. Corrocher R, Bambara LM, Pachor ML, Biasi D, Stanzial A, De Sandre G: Serum folate binding capacity in leukemias, liver diseases and pregnancy. Acta Haematol (Basel) 61:203, 1979

    CAS  Google Scholar 

  18. Corrocher R, Bambara LM, Pachor ML, De Sandre G: Folate binding proteins. Recenti Prog Med 66:361, 1979b

    PubMed  CAS  Google Scholar 

  19. Corrocher R, Bambara LM, Pachor ML, Stanzial AM, Biasi D: Different binding proteins for folic acid in serum of patients with acute hepatitis. Acta Haematol (Basel) 64:281, 1980

    CAS  Google Scholar 

  20. Corrocher R, Pachor ML, Bambara LM, Ambrosetti A, De Sandre G: Folic acid binding protein in chronic granulocytic leukemia: The effect of methotrexate. Acta Haematol (Basel) 670:341, 1978

    Google Scholar 

  21. Corrocher R, Pachor ML, Bambara LM, De Sandre G: Evidence for a folic acid binding protein in human cell membrane. Acta Haematol (Basel) 66:202, 1981

    CAS  Google Scholar 

  22. da Costa M, Fischer C: Immunologic heterogeneity of the folate-binding proteins from chronic myelogenous leukemia cells and myelofibrosis spleen. J Lab Clin Med 98:956, 1981

    PubMed  Google Scholar 

  23. da Costa M, Rothenberg SP: Studies with the folate binding protein in chronic granulocytic leukemia cells. I. Synthesis and release of binder by cells in short-term culture. Br J Haematol 34:581, 1976

    PubMed  Google Scholar 

  24. da Costa M, Rothenberg SP, Beckman SJ: Rat liver muclei contain receptors for a folate binding protein. Proc Soc Exp Biol Med 174:350, 1983

    PubMed  CAS  Google Scholar 

  25. da Costa M, Sharon M: The synthesis of folate binding protein in lymphocytes during transformation. Br J Haematol 46:575, 1980

    PubMed  CAS  Google Scholar 

  26. Elsborg L, Hansen SI, Skovbjerg H, Holm J, Lyngbye J: Chromatographic isolation and characterization of folate binding proteins in porcine intestinal epithelial brush border membrane. Int J Vitam Nutr Res 50:267, 1980

    PubMed  CAS  Google Scholar 

  27. Elwood PC, Kane MA, Portillo RM, Kolhouse JF: The isolation, characterization and comparison of the membrane-associated and soluble folate-binding proteins from human KB cells. J Biol Chem 261:15416, 1986

    PubMed  CAS  Google Scholar 

  28. Fernandes-Costa F, Metz J: Binding of methylfolate and pteroylglutamic acid by the specific serum folate binder. J Lab Clin Med 93:181, 1979

    PubMed  CAS  Google Scholar 

  29. Fernandes-Costa F, Metz J: Role of serum folate binders in the delivery of folate to tissues and to the fetus. Br J Haematol 48:335, 1979

    Google Scholar 

  30. Fernandes-Costa F, Metz J: The specific folate-binding capacity of serum. Evidence that levels are not directly related to folate nutrition but influenced by hormonal status. J Lab Clin Med 98:119, 1981

    PubMed  CAS  Google Scholar 

  31. Fischer CD, da Costa M, Rothenberg SP: Properties of purified folate binding proteins from chronic myelogenous leukemia cells. Biochim Biophys Acta 543:328, 1978

    PubMed  CAS  Google Scholar 

  32. Fisher SE, Inselman LS, Duffy L, Atkinson M, Spencer H, Chang B: Ethanol and fetal nutrition: Effect of chronic ethanol exposure on rate placental growth and membrane-associated folic acid receptor binding activity. J Pediatr Gastroenterol Nutr 4:645, 1985

    PubMed  CAS  Google Scholar 

  33. Ford JE: Some observations on the possible nutritional significance of vitamin B12 and folate binding proteins in milk. Br J Nutr 31:243, 1974

    PubMed  CAS  Google Scholar 

  34. Ghitis J: The folate binding protein in milk. Am J Clin Nutr 20:1, 1967

    PubMed  CAS  Google Scholar 

  35. Goldman ID: The characteristics of membrane transport of ame-thopterin and the naturally occurring folates. Ann NY Acad Aci 186:400, 1971

    CAS  Google Scholar 

  36. Goldman ID: A model for the study of heteroexchange diffusion: Methotrexate-folate interactions in L1210 leukemia and Ehrlich ascites tumor cells. Biochim Biophys Acta 233:635, 1976

    Google Scholar 

  37. Gregory JF: Denaturation of the folacin-binding protein in pasteurized milk products. J Nutr 113, 1329, 1982

    Google Scholar 

  38. Gross S, Kamen B, Fanaroff A, Caston D: Folate compartments during gestational maturation. J Pediatr 96:842, 1980

    PubMed  CAS  Google Scholar 

  39. Halsted CH: The intestinal absorption of folates. Am J Clin Nutr 32:846, 1979

    PubMed  CAS  Google Scholar 

  40. Hansen SI, Holm J, Lyngbye J: Change in binding properties of folate binding protein in cow’s whey due to removal of a cofactor during affinity Chromatographie purification. Biochim Biophys Acta 579:479, 1979

    PubMed  CAS  Google Scholar 

  41. Hansen SI, Holm J, Lyngbye J: High-affinity protein binding of folate in urine. IRCS Med Sci 8:846, 1980

    CAS  Google Scholar 

  42. Hansen SI, Holm J, Lyngbye J: Evidence that the low-affinity folate binding protein in erythrocyte hemolysate is identical to hemoglobin. Clin Chem 27:1247, 1981

    PubMed  CAS  Google Scholar 

  43. Hansen SI, Holm J, Lyngbye J: Detergent activation of the binding protein in the folate radioassay. Clin Chem 28:117, 1982

    PubMed  CAS  Google Scholar 

  44. Hansen SI, Holm J, Lyngbye J: A high affinity folate binding protein in human cerebrospinal fluid. Acta Neurol Scand 71:133, 1985

    PubMed  CAS  Google Scholar 

  45. Henderson GB, Grzelakowska-Sztabert B, Zevely EM, Huennekens FM: Binding properties of the 5-methyltetrahydrofolate methotrexate transport system in L1210 cells. Arch Biochem Biophys 202:144, 1980

    PubMed  CAS  Google Scholar 

  46. Henderson GB, Tsuji JM, Kumar HP: Mediated uptake of polate by a high-affinity binding protein in sublines of L1210 cells adapted to nanomolar concentrations of polate. J Membrane Biol 101:247, 1988

    CAS  Google Scholar 

  47. Herbert V, Colman N: Release of vitamin binding proteins from granulocytes by lithium: vitamin B12 and folate binding proteins. Adv Exp Med Biol 127:61, 1980

    PubMed  CAS  Google Scholar 

  48. Holm J, Hansen SI, Lyngbye J: Cofactor in serum for high affinity folate binding in milk. Clin Chem 26:1591, 1980

    PubMed  CAS  Google Scholar 

  49. Holm J, Hansen SI, Lyngbye J: High and low affinity binding of folate to proteins in serum of pregnant women. Biochim Biophys Acta 629:539, 1980

    PubMed  CAS  Google Scholar 

  50. Holm J, Hansen SI, Lyngbye J: A high affinity folate binding protein in umbilical cord serum. Scan J Clin Lab Invest 40:523, 1980

    CAS  Google Scholar 

  51. Holm J, Hansen SI, Lyngbye J: Characteristics of high-affinity folate binding in serum of a patient with chronic myelogenous leukemia. Clin Chim Acta 105:383, 1980

    PubMed  CAS  Google Scholar 

  52. Holm J, Hansen SI, Lyngbye J: High affinity binding of folate to a serum protein in chronic myelogenous leukemia. Effect of binder concentration, pH, and temperature. Clin Chem 27:316, 1981

    CAS  Google Scholar 

  53. Holm J, Hansen SI, Lyngbye J: High affinity folate binding in chronic myelogenous leukaemia serum: relationship of binding characteristics to activity of disease and binder concentration. Scand J Haematol 26:153, 1981

    PubMed  CAS  Google Scholar 

  54. Holm J, Hansen SI, Lyngbye J: High-affinity folate binding in leukocyte lysate from normal subjects: effect of concentration of binding protein, temperature and pH. Acta Haematol (Basel) 70:269, 1983

    CAS  Google Scholar 

  55. Holm J, Hansen SI, Lyngbye J: A high-affinity folate binding protein in normal human leucocytes: Ligand binding characteristics, ionic charge and molecular size. Biosci Rep 5:683, 1985

    PubMed  CAS  Google Scholar 

  56. Home DW, Briggs WT, Wagner C: Enzymic synthesis of (d)-L-5-methyltetrahydropteroylglutamate of high specific radioactivity. Methods Enzymol 66:545, 1980

    Google Scholar 

  57. Huennekens FM: Transport of folate compounds, pterins and adenine in L1210 mouse leukemia cells. Adv Enzyme Regul 20:389, 1981

    Google Scholar 

  58. Huennekens FM, Suresh MR, Grinishaw CE: In Chemistry and Biology of Pteridines, edited by Blair JA, p 1. New York, Walter de Gruyter & Co, 1983

    Google Scholar 

  59. Huennekens FM, Vitols KS, Henderson GB: Transport of folate compounds in bacterial and mammalian cells. Adv Enzymol 47:313, 1978

    PubMed  CAS  Google Scholar 

  60. Izhak G, Galewski K, Rachmilewitz M, Grossowicz N: The absorption of milk-bound pteroylglutamic acid from small intestine segments. Proc Soc Exp Biol Med 140:248, 1972

    Google Scholar 

  61. Jensen ON, Olesen OV: Human choroid plexus transport of folates. Acta Psychol Scand 47:206, 1971

    CAS  Google Scholar 

  62. Kamen BA, Caston JD: Purification of folate binding factor in normal umbilical cord serum. Proc Nat Acad Sci USA 72:4261, 1975

    PubMed  CAS  Google Scholar 

  63. Kamen BA, Capdevila A: Receptor-mediated folate accumulation is regulated by the cellular folate content. Proc Natl Acad Sci USA 83:5983, 1986

    PubMed  CAS  Google Scholar 

  64. Kamen BA, Caston JD: Properties of a folate binding protein (FBP) isolated from porcine kidney. Biochem Pharmacol 35:2323, 1986

    PubMed  CAS  Google Scholar 

  65. Kamen BA, Gross S, Caston JD: Role of cerebrospinal fluid binder in the uptake of folate by lymphoblasts. Methods Enzymol 66:678, 1980

    PubMed  CAS  Google Scholar 

  66. Kane MA, Elwood PC, Portillo RM, Antony AC, Najfeld V, Finley A, Waxman S, Kolhouse JF: Influence on immunoreactive folate binding proteins of extracellular folate concentration in cultured human cells. J Clin Invest 81:2398, 1988

    Google Scholar 

  67. Kane MA, Elwood PC, Portillo RM, Antony AC, Kolhouse JF: The interrelationship of the soluble and membrane-associated folate binding proteins in human KB cells. J Biol Chem 261:15625, 1986

    PubMed  CAS  Google Scholar 

  68. Kane MA, Portillo RM, Elwood PC, Antony Ac, Kolhouse JF: The influence of extracellular folate concentration on methotrexate uptake by human KB cells. Partial characterization of a membrane-associated methotrexate binding protein. J Biol Chem 261:44, 1986

    PubMed  CAS  Google Scholar 

  69. Kesavan V, Noronha JM: Noninvolvement of a rat intestinal folate binding protein in physiological folate absorption. Experientia 40:8030, 1984

    Google Scholar 

  70. Lanzkowski P, Erlandson ME, Bezan AI: Isolated defect of folic acid absorption associated with mental retardation and cerebral calcification. Blood 34:452, 1969

    Google Scholar 

  71. Leslie GI, Rowe PB: Folate binding by the brush border membrane proteins of small intestinal epithelial cells. Biochemistry 11:1696, 1972

    PubMed  CAS  Google Scholar 

  72. Levitas A, Braden M, Van Norman K, Hagerman R, McBogg P: Treatment and prevention. In The Fragile X Syndrome, edited by Hagerman RJ & McBogg PM, pp 201–228. Dillon, CO, Spectra Publishing Co, 1983

    Google Scholar 

  73. Luhby AL, Eagle FJ, Roth E, Cooperman J: Relapsing megaloblastic anemia in an infant due to a specific defect in gastrointestinal absorption of folic acid. Am J Dis Child 102:94, 1961

    Google Scholar 

  74. Luhrs CA, Pitiranggon P, da Costa M, Rothenberg SP, Slomiany BL, Brink L, Guillermo IT, Stein S: Purified membrane and soluble folate binding proteins from cultured KB cells have similar amino acid compositions and molecular weights, but differ in fatty acid acylation. Proc Natl Acad Sci USA 84:6546, 1987

    PubMed  CAS  Google Scholar 

  75. Luhrs CA, Sadavisan E, da Costa M, Rothenberg SP: The isolation and properties of multiple forms of folate binding protein in cultured KB cells. Arch Biochem Biophys 250:94, 1986

    PubMed  CAS  Google Scholar 

  76. Lyngbye J, Hansen SI, Holm J: Kinetics of folate-protein binding. Methods Enzymol 66:694, 1980

    PubMed  CAS  Google Scholar 

  77. McHugh M, Cheng YC: Demonstration of a high affinity folate binder in human cell membranes and its characterization in cultured human KB cells. J Biol Chem 254:11312, 1979

    PubMed  CAS  Google Scholar 

  78. Nixon PF, Bertino JR: Enzymic preparations of radiolabeled +—L-5-methyltetrahydrofolate and +—L-formyltetrahydrofolate. Methods Enzymol 66:547, 1980

    PubMed  CAS  Google Scholar 

  79. Nutrition Review: Serum folate binders are not correlated to folate nutritional status. Nutr Rev 40:234, 1982

    Google Scholar 

  80. Nutrition Review: Folate binder in milk may facilitate folate absorption. Nutr Rev 40:90, 1982

    Google Scholar 

  81. Pristoupilova K, Slavikova V: Specific folic acid binding protein in human saliva. Cas Lek Cesk 119:1103, 1980

    PubMed  CAS  Google Scholar 

  82. Reisenauer AM, Chandler CJ, Halsted CH: Folate binding and hydrolysis by pig intestinal brush-border membranes. Am J Physiol 251:G481, 1986

    PubMed  CAS  Google Scholar 

  83. Retief FP, Heyns AP, Oosthuizen M, et al: Comparison between the unsaturated plasma folate binder and in vivo labeled plasma folate binder. Acte Haematol (Basel) 60:296, 1978

    CAS  Google Scholar 

  84. Rochman H, Selhub J, Karrison T: Folate binding protein and the estrogen receptor in breast cancer. Cancer Detect Prev 8:71, 1985

    PubMed  CAS  Google Scholar 

  85. Rothenberg SP, da Costa M: Further observations on the folate-binding factor in some leukemic cells. J Clin Invest 50:719, 1971

    PubMed  CAS  Google Scholar 

  86. Rothenberg SP, Fischer CD, da Costa M: Binding of N5,N10-methylene tetrahydrofolate and the inhibition of thymidylate synthesis by a folate binding protein. Biochim Biophys Acta 543:340, 1978

    PubMed  CAS  Google Scholar 

  87. Rubinoff M, Schreiber C, Waxman S: The isolation and characterization of the folate binding protein from goat milk. FEBS Lett 75:244, 1977

    PubMed  CAS  Google Scholar 

  88. Rubinoff M, Abramson R, Schreiber C, Waxman S: Effect of a folate-binding protein on the plasma transport and tissue distribution of folic acid. Acta Haematol (Basel) 65:145, 1981

    CAS  Google Scholar 

  89. Sadavisan E, Rothenberg SP, da Costa M, Brink L: Characterization of multiple forms of folate-binding protein from human leukemia cells. Biochim Biophys Acta 882:311, 1986

    Google Scholar 

  90. Sadavisan E, Rothenberg SP: Isolation of the cDNA clone for a human folate binding protein (FBP) (abstr.) FASEB J 46:1004, 1987

    Google Scholar 

  91. Said HM, Home DW, Wagner C: Effect of human milk folate binding protein on folate intestinal transport. Arch Biochem Biophys 251:114, 1986

    PubMed  CAS  Google Scholar 

  92. Said HM, Strum WB: Cyclic AMP-3′,5-monophosphate and folate transport in rat jejunum. Biochem Biophys Res Commun 115:756, 1983

    PubMed  CAS  Google Scholar 

  93. Selhub J, Arnold R, Smith AM, Picciano MF: Milk folate binding protein (FBP): A secretory protein for folate? Nutr Res 4:181, 1984

    CAS  Google Scholar 

  94. Selhub J, Dhar GJ, Rosenberg IH: Gastrointestinal absorption of folates and antifolates. Pharmacol Ther 20:397, 1983

    PubMed  CAS  Google Scholar 

  95. Selhub J, Emmanouel D, Stavropoulos, Arnold R: Am J Physiol 252:F750, 1986

    Google Scholar 

  96. Selhub J, Franklin WA: The folate binding protein of rat kidney. Purification, properties, and cellular distribution. J Biol Chem 259:6601, 1984

    CAS  Google Scholar 

  97. Selhub J, Gay AC, Rosenberg IH: Effect of anions on folate binding by isolated brush border membranes from rat kidney. Biochim Biophys Acta 557:372, 1979

    PubMed  CAS  Google Scholar 

  98. Selhub J, Nakamura S, Carone FA: Renal folate absorption and the kidney folate binding protein. II. microinfusion studies. Am J Physiol 252:F757, 1986

    Google Scholar 

  99. Selhub J, Powell GM, Rosenberg IH: Intestinal transport of 5-methyltetrahydrofolate. Am J Physiol 246:G515–G520

    Google Scholar 

  100. Selhub J, Rosenberg IH: Folate transport in isolated brush border membrane vesicles from rat intestine. J Biol Chem 236:4489, 1981

    Google Scholar 

  101. Shane B, Tamura T, Stokstad ELR: Folate assay: A comparison of radioassay and microbiological methods. Clin Chim Acta 100:13, 1980

    PubMed  CAS  Google Scholar 

  102. Sheppard K, Bradbury DA, Davies JM, Ryrie DR: Cobalamin and folate binding proteins in human tumour tissue. J Clin Pathol 37:1336, 1984

    PubMed  CAS  Google Scholar 

  103. Sirotnak FM: Correlates of folate analog transport, pharmacokinetics and selective antitumor action. Pharmacol Ther 8:71, 1980

    CAS  Google Scholar 

  104. Sirotnak FM, Goutas LJ, Jacobsen DM, Mines LS, Barrueco JR, Gaumont Y, Gaumont Y, Kisliuk R: Carrier-mediated transport of folate compounds on L1210 cells. Biochem Pharmacol 36:1659, 1987

    PubMed  CAS  Google Scholar 

  105. Soliman HA, Olesen H: Folic acid binding by human plasma albumin. Scan J Clin Lab Invest 36:299, 1976

    CAS  Google Scholar 

  106. Spector R: Identification of folate binding macromolecule in rabbit choroid plexus. J Biol Chem 252:3364, 1977

    PubMed  CAS  Google Scholar 

  107. Spector R: Affinity of folic acid for the folate binding protein of choroid plexus. Arch Biochem Biophys 194:632, 1979

    PubMed  CAS  Google Scholar 

  108. Suleiman SA, Spector R: Purification and characterization of a folate binding protein from porcine choroid plexus. Arch Biochem Biophys 208:87, 1981

    PubMed  CAS  Google Scholar 

  109. Suleiman SA, Spector R, Cancilla P: Partial purification and characterization of a folate binding protein from human choroid plexus. Neurochem Res 6:333, 1981

    PubMed  CAS  Google Scholar 

  110. Svendsen I, Hansen SI, Holm J, Lyngbye J: Isolation and characterization of the folate-binding protein from cow’s milk. Carlsberg Res Commun 44:89, 1979

    CAS  Google Scholar 

  111. Svendsen I, Hansen SI, Holm J, Lyngbye J: The complete amino acid sequence of the folate-binding protein from cow’s milk. Carlsberg Res Commun 49:123, 1984

    CAS  Google Scholar 

  112. Wagner C: Folate-binding proteins. Nutr Rev 43:293, 1985

    PubMed  CAS  Google Scholar 

  113. Waxman S: Folate binding proteins. Br J Haematol 29:23, 1975

    PubMed  CAS  Google Scholar 

  114. Waxman S: Studies on the origin of serum folate binding protein. In Chemistry and Biology of the Pteridines, edited by Kisliuk GM, Brown GM, P 619. North Holland, Elsevier, 1979

    Google Scholar 

  115. Waxman S, Schreiber C: Characteristics of folic-acid binding protein in folate-deficient serum. Blood 42:291, 1973

    PubMed  CAS  Google Scholar 

  116. Waxman S, Schreiber C: The role of folic acid binding proteins (FABP) in the cellular uptake of folates. Proc Soc Exp Biol Med 147:760, 1974

    PubMed  CAS  Google Scholar 

  117. Waxman S, Schreiber C: The purification and characterization of the low molecular weight human folate binding protein using affinity chromatography. Biochemistry 14:5422, 1975

    PubMed  CAS  Google Scholar 

  118. Waxman S, Schreiber C: Determination of folate by use of radioactive folate and binding proteins. Methods Enzymol 66:468, 1980

    PubMed  CAS  Google Scholar 

  119. Waxman S, Schreiber C, Rubinoff M: The significance of folate binding proteins in folate metabolism. Adv Nutr Res 1:55, 1977

    CAS  Google Scholar 

  120. Wittwer AJ, Wagner C: Identification of folate binding protein of mitochondria as dimethylglycine dehydrogenase. Proc Natl Acad Sci USA 77:4484, 1980

    PubMed  CAS  Google Scholar 

  121. Wittwer AJ, Wagner C: Identification of folate-binding proteins of rat liver mitrochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate-binding characteristics. J Biol Chem 256:4102, 1981

    CAS  Google Scholar 

  122. Wittwer AJ, Wagner C: Identification of the folate binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavo protein nature and enzymatic properties of the purified proteins. J Biol Chem 256:4109, 1981

    CAS  Google Scholar 

  123. Zamarano AF, Arnalick F, Sanchez Casas E, Sicilia A, Solis C, Vazquez JJ, Gasalla R: Levels of iron, vitamin B12, folic acid and their binding proteins during pregnancy. Acta Haemat 74:92, 1985.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Oncology and Hematology Sections, Denver Veterans Administration Medical Center and University of Colorado Health Sciences Center, Denver, Colorado, USA

    Madeleine A. Kane & Samuel Waxman

  2. Chemotherapy Foundation Laboratory, Department of Medicine, Mount Sinai Medical Center, New York, New York, USA

    Madeleine A. Kane & Samuel Waxman

Authors
  1. Madeleine A. Kane
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Samuel Waxman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pathology and Cell Biology, Jefferson Medical College Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Emanuel Rubin MD (Gonzalo Aponte Professor and Chairman) & Ivan Damjanov MD (Professor) (Gonzalo Aponte Professor and Chairman) &  (Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer Science+Business Media New York

About this chapter

Cite this chapter

Kane, M.A., Waxman, S. (1990). Role of Folate Binding Proteins in Folate Metabolism. In: Rubin, E., Damjanov, I. (eds) Pathology Reviews • 1990. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0485-5_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-0485-5_4

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6783-6

  • Online ISBN: 978-1-4612-0485-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation