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Contractile Cells in Normal and Fibrotic Lung

  • Chapter
Pathology Reviews • 1990

Abstract

Interstitial pulmonary fibrosis represents a group of fibrosing lung diseases, often of unknown etiology, characterized by hypercellularity and deposition of connective tissue within the interstitium of the alveolar wall (32, 65). Increased “stiffness” of the lung leads to reduced lung volumes and lowered dynamic compliance (80). In interstitial fibrosis, as well as several other forms of lung injury, there is an apparent increase in smooth muscle (SM) cells organized into bundles within areas of the lung where these cells normally are present but difficult to detect, such as the alveolar duct (69, 89, 119). This increase in acinar SM can be quite prominent, and, in some cases, the degree of parenchymal SM hyperplasia is sufficiently excessive to be referred to as “muscular cirrhosis of the lung” (2, 7, 33, 110, 152).

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Authors and Affiliations

  1. Department of Anatomy, Physiological Sciences and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA

    Kenneth B. Adler, Robert B. Low, Kevin O. Leslie, John Mitchell & John N. Evans

  2. Department of Physiology & Biophysics, College of Medicine, University of Vermont, Burlington, Vermont, USA

    Kenneth B. Adler, Robert B. Low, Kevin O. Leslie, John Mitchell & John N. Evans

  3. Department of Phathology, College of Medicine, University of Vermont, Burlington, Vermont, USA

    Kevin O. Leslie, John Mitchell & John N. Evans

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  1. Kenneth B. Adler
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  2. Robert B. Low
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  3. Kevin O. Leslie
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  4. John Mitchell
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  5. John N. Evans
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Editors and Affiliations

  1. Department of Pathology and Cell Biology, Jefferson Medical College Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Emanuel Rubin MD (Gonzalo Aponte Professor and Chairman) & Ivan Damjanov MD (Professor) (Gonzalo Aponte Professor and Chairman) &  (Professor)

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Adler, K.B., Low, R.B., Leslie, K.O., Mitchell, J., Evans, J.N. (1990). Contractile Cells in Normal and Fibrotic Lung. In: Rubin, E., Damjanov, I. (eds) Pathology Reviews • 1990. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0485-5_3

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  • DOI: https://doi.org/10.1007/978-1-4612-0485-5_3

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