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Molecular Mechanisms of Oncogenesis

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Pathology Reviews • 1990

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Abstract

A review of the literature of the past several years shows hundreds of reports describing oncogene identification, expression, deregulation, amplification and mutation, chromosomal alterations and molecular events in experimental and naturally occurring cancer. It is our intention here to focus on concepts and principles and to present an overview of the molecular events thought to be important in cancer. We discuss the history and nature of oncogenes and then consider cytogenetic and molecular mechanisms which may be operative in neoplasia. Because many contributions originate from analyses of relatively rare pediatric cancers, particular emphasis will be accorded cancers arising in children. Since the molecular events uncovered in the childhood cancers appear to be operative in adults, we will consider a few of these diseases as well.

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  1. Departments of Pathology, Pediatrics and Medicine, McGill University Faculty of Medicine, The Montreal Children’s Hospital and Ludwig Institute for Cancer Research (Montreal Branch), Royal Victoria Hospital, UK

    Thomas A. Seemayer & Webster K. Cavenee

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  1. Department of Pathology and Cell Biology, Jefferson Medical College Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Emanuel Rubin MD (Gonzalo Aponte Professor and Chairman) & Ivan Damjanov MD (Professor) (Gonzalo Aponte Professor and Chairman) &  (Professor)

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Seemayer, T.A., Cavenee, W.K. (1990). Molecular Mechanisms of Oncogenesis. In: Rubin, E., Damjanov, I. (eds) Pathology Reviews • 1990. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0485-5_11

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