Molecular Mechanisms of Oncogenesis

  • Thomas A. Seemayer
  • Webster K. Cavenee


A review of the literature of the past several years shows hundreds of reports describing oncogene identification, expression, deregulation, amplification and mutation, chromosomal alterations and molecular events in experimental and naturally occurring cancer. It is our intention here to focus on concepts and principles and to present an overview of the molecular events thought to be important in cancer. We discuss the history and nature of oncogenes and then consider cytogenetic and molecular mechanisms which may be operative in neoplasia. Because many contributions originate from analyses of relatively rare pediatric cancers, particular emphasis will be accorded cancers arising in children. Since the molecular events uncovered in the childhood cancers appear to be operative in adults, we will consider a few of these diseases as well.


Burkitt Lymphoma Acoustic Neuroma Retinoblastoma Gene Cellular Oncogene Spinal Cord Glioma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Thomas A. Seemayer
    • 1
  • Webster K. Cavenee
    • 1
  1. 1.Departments of Pathology, Pediatrics and MedicineMcGill University Faculty of Medicine, The Montreal Children’s Hospital and Ludwig Institute for Cancer Research (Montreal Branch)UK

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