Skip to main content
SpringerLink
Log in

Drug Allergy in Cystic Fibrosis

  • Chapter
Cystic Fibrosis

Part of the book series: Allergy and Immunology ((ALIM,volume 1))

Abstract

In the absence of a rational therapeutic approach to the basic molecular defect in cystic fibrosis (CF), contemporary therapy remains an amalgam of variably effective empiric treatments aimed at various clinical manifestations and components of this complex and protean disease. The result is a remarkable polypharmaceutical regimen of antibiotics, pancreatic enzymes, nutritional supplements, bronchodilators, and assorted other medications. In this chapter, I will review the two components of this polypharmacy that have resulted in significant problems with allergic reactions, not only in CF patients, but also (in some cases) in their caretakers. These two components are antibiotic and pancreatic enzyme therapy. Among the antibiotics used to treat pulmonary infection in CF, antipseudomonal semisynthetic penicillin derivative and cephalosporin β-lactam drugs have caused most of the allergic problems found in patients; accordingly, the major focus of this review will be on these compounds.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Sullivan, T. J. (1982), Pediatr. Infect. Dis. 1, 344–350.

    Article  CAS  PubMed  Google Scholar 

  2. Saxon, A., Beali, G. N., Rohr, A. S., and Adehnan, D. C. (1987), Ann. Int. Med. 107, 204–215.

    Article  CAS  PubMed  Google Scholar 

  3. Ressler, C. and Mendelson, L. M. (1987), Ann. Allergy 59, 167–170.

    CAS  PubMed  Google Scholar 

  4. Van Dellen, R. G., Walsh, W. E., Peters, G. A., and Gleich, G. J. (1971),J. Allergy 47, 230–236.

    PubMed  Google Scholar 

  5. Petz, L. D. (1978), J. Infect. Dis. 137, S74–S79.

    Article  PubMed  Google Scholar 

  6. Sullivan, T.J., Wedner, H.J., Shatz, G.S., Yecies, L.D., and Parker, C.W.(1981), J. Allergy Clin. Immunol. 68, 171–180.

    Article  CAS  PubMed  Google Scholar 

  7. Solley, G. O., Gleich, G. J., and Van Dellen, R. G. (1982), J. Allergy Clin. Immunol. 69, 238–244.

    Article  CAS  PubMed  Google Scholar 

  8. Saxon, A., Adelman, D.C., Patel, A., Hajdu, R., and Calandra, G.B. (1988), J. Allergy Clin. Immunol. 82, 213–217.

    Article  CAS  PubMed  Google Scholar 

  9. Blanca, M., Fernandez, J., Miranda, A., Terrados, S., Torres, M. J., Vega, J.M., Avila, M. J., Perez, E., Garcia, J. J., and Suau, R. (1989), J. Allergy Clin. Immunol. 83, 381–385.

    Article  CAS  PubMed  Google Scholar 

  10. Sogn, D. (1984), J. Allergy Clin. Immunol. 74, 589–593.

    Article  CAS  PubMed  Google Scholar 

  11. Rourk, M. and Spock, A. (1970), CF Club Abstr. 19, 20.

    Google Scholar 

  12. Patterson, P. and Snyder, K (1976), CF Club Abstr. 25, 54.

    Google Scholar 

  13. Moller, N., Ahlstedt, S., Skov, S., and Norm, S. (1980), Allergy 35, 135–138.

    Article  CAS  PubMed  Google Scholar 

  14. Brown, L. A., Goldberg, N. D., and Shearer, W. T. (1982), J. Allergy Clin. Immunol. 69, 51–54.

    Article  CAS  PubMed  Google Scholar 

  15. Moss, R. B., Babin, S., Blessing, J., and Lewiston, N. J. (1984), J. Pediatr. 104, 460–466.

    Article  CAS  PubMed  Google Scholar 

  16. Hilman, B. C. and Rao, K (1986), J. Allergy Clin. Immunol. 77, 167.

    Google Scholar 

  17. Galant, S., Posner, L., Lee, N., Hicks, D., Wilkinson, B., and Ellis, M. (1987), J. Allergy Clin. Immunol. 79, 199.

    Google Scholar 

  18. Earl, H. S. and Sullivan, T. J. (1987), J. Allergy Clin. Immunol. 79, 477–483.

    Article  CAS  PubMed  Google Scholar 

  19. Sullivan, T. J., Ong, R.C., and Gilliam, L. K. (1989), J. Allergy Clin. Immunol. 83, 270.

    Article  Google Scholar 

  20. Moss, R. B., McClelland, E., Rubio, T., Hillman, B., Williams, R., and Adkinson, N. F. Rev. Infect. Dis., in press.

    Google Scholar 

  21. Neu, H. C. (1986), Rev. Infect. Dis. 8, S237–S259.

    Article  CAS  PubMed  Google Scholar 

  22. Adkinson, N. F., Swabb, E. A., and Sugarman, A. A. (1984), Antimicrob. Agents Chemother. 25, 93–97.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Saxon, A., Hassner, A., Swabb, E. A., Wheeler, B., and Adkinson, N. F. (1984), J. Infect. Dis. 149, 16–22.

    Article  CAS  PubMed  Google Scholar 

  24. Adkinson, N. F., Saxon, A., Spence, M. R., and Swabb, E. A. (1985), Rev. Infect. Dis. 7, S613–S621.

    Article  CAS  PubMed  Google Scholar 

  25. Saxon, A., Swabb, E. A., and Adkinson, N. F. (1985), Am. J. Med. 78 (suppl 2A), 19–26.

    Article  CAS  PubMed  Google Scholar 

  26. Loria, R.C., Finnerty, N., and Wedner, H. J. (1989), J. Allergy Clin. Immunol. 83, 735–737.

    Article  CAS  PubMed  Google Scholar 

  27. O’Donovan, W. J. and Klorfajn, I. (1946), Lancet 2, 444–446.

    Article  CAS  Google Scholar 

  28. Chiarmonte, J. S. and Pinsker, W. (1978), Ann. Allergy 41, 111, 112.

    Google Scholar 

  29. Sullivan, T.J., Yecies, L.D., Shatz, G.S., Parker, C.W., and Wedner, H.J. (1982), J. Allergy Clin. Immunol. 69, 275–282.

    Article  CAS  PubMed  Google Scholar 

  30. Wendel, G. D., Stark, B. J., Jamison, R. B., Molina, R. D., and Sullivan, T. J. (1985), N. Engl J. Med. 312, 1229–1232.

    Article  PubMed  Google Scholar 

  31. Stark, B. J., Earl, H. S., Gross, G. N., Lumry, W. R., Goodman, E. L., and Sullivan, T. J. (1987), J. Allergy Clin. Immunol. 79, 523–532.

    Article  CAS  PubMed  Google Scholar 

  32. Gorevic, P. D. and Levine, B. B. (1981), J. Allergy Clin. Immunol. 68, 267–272.

    Article  CAS  PubMed  Google Scholar 

  33. Sullivan, T. J. (1982), J. Allergy Clin. Immunol. 69, 500–508.

    Article  CAS  PubMed  Google Scholar 

  34. Naclerio, R., Mizrahi, E. A., and Adkinson, N. F. (1983), J. Allergy Clin. Immunol. 71, 294–301.

    Article  CAS  PubMed  Google Scholar 

  35. Pienkowski, M. M., Kazmier, J., and Adkinson, N. F. (1988), J. Allergy Clin. Immunol. 82, 171–178.

    Article  CAS  PubMed  Google Scholar 

  36. Moss, R. B. (1989), J. Allergy Clin. Immunol. 83, 1138.

    Article  CAS  PubMed  Google Scholar 

  37. Borish, L., Tamir, R., and Rosenwasser, L. J. (1987), J. Allergy Clin. Immunol. 80, 314–319.

    Article  CAS  PubMed  Google Scholar 

  38. Mastella, G., Agostini, M., Barlocco, G., Bonomi, U., Borgo, G., Bozzino, L., Cabrini, G., Capelletti, L. M., Castellani, L., Confort, M., Marazzani, S., Martini, N., Montemezzi, P., Paulon, G., Pederzini, F., Sancassani, L., and Scroccaro, G. (1983), J. Antimicrob. Chemother. 12 Suppl A, 297–311.

    Article  PubMed  Google Scholar 

  39. Møller, N. E., Eriksen, K. R., Feddersen, C., Flensbørg, E. W., Høiby, N., Nom, S., Rosendal, K., Schiøtz, P. O., and Skov, P. S. (1982), Eur. J. Resp. Dis. 63, 130–139.

    Google Scholar 

  40. Discussion. (1981), Scand. J. Infect. Dis. (Suppl) 29, 102,103.

    Google Scholar 

  41. Reed, M. D., Stern, R.C., Myers, C. M., Yamashita, T. S., and Blumer, J. L. (1984), Abstr. Int. Congress Antimicrob. Agent Chemother. (abstract 15849), p. 238.

    Google Scholar 

  42. Strandvik, B. (1984), Lancet 1, 857, 858.

    Google Scholar 

  43. Stead, R. J., Kennedy, H. G., Hodson, M. E., and Batten, J.C. (1985), Thorax 40, 184–186.

    Article  CAS  PubMed  Google Scholar 

  44. Dolan, T. F. and Meyers, A. (1974), Am. Rev. Respir. Dis. 110, 812, 813.

    PubMed  Google Scholar 

  45. Bergner, A. and Bergner, R. K. (1975), Pediatrics 55, 814–817.

    CAS  PubMed  Google Scholar 

  46. Hill, D. (1975), Med. J. Aust. 2, 553–555.

    CAS  PubMed  Google Scholar 

  47. Twarog, F., Weinstein, S.F., Khaw, K.T., Strieder, D.J., and Colten, H.R. (1977), J. Allergy Clin. Immunol. 59, 35–40.

    Article  CAS  PubMed  Google Scholar 

  48. Sakula, A. (1977), Br. J. Dis. Chest 71, 295–299.

    Article  CAS  PubMed  Google Scholar 

  49. Ganier, M. and Lieberman, P. (1979), Clin. Allergy 9, 125–132.

    Article  CAS  PubMed  Google Scholar 

  50. Parsons, M. (1980), Trypsin binding Plasma Proteins in Cystic Fibrosis, (Doctorial Thesis), Stanford University, Palo Alto, CA.

    Google Scholar 

  51. Romeo, G., Parsons, M., Bossen, A., Blessing-Moore, J., and Cavalli-Sforza, L. (1978), Nature 274, 909–911.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Allergy/Pulmonary Division, Department of Pediatrics, Stanford University School of Medicine, Children’s Hospital at Stanford, 520 Sand Hill Road, 95304, Palo Alto, CA, USA

    Richard B. Moss

Authors
  1. Richard B. Moss
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Stanford University School of Medicine, Palo Alto, California, USA

    Richard B. Moss

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer Science+Business Media New York

About this chapter

Cite this chapter

Moss, R.B. (1990). Drug Allergy in Cystic Fibrosis. In: Moss, R.B. (eds) Cystic Fibrosis. Allergy and Immunology, vol 1. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0475-6_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-0475-6_12

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6778-2

  • Online ISBN: 978-1-4612-0475-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation