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Drug Discovery pp 333–348Cite as

Albuterol

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Abstract

Bronchial asthma can be simply defined as reversible airways obstruction occurring in people with airways hypersensitivity. Since a major component of this obstruction is bronchospasm, the primary goal of asthma therapy is relief and/or prevention of bronchospasm. During the earlier part of this century, the mainstay for relief from the bronchospasm of acute severe asthmatic attacks was the endogenous adrenergic agonist, epinephrine (parenterally administered); it is still quite widely used, by subcutaneous injection, to relieve acute asthma. However, since the 1940s, the synthetic agent isoproterenol (injected and inhaled) has served as an alternative adrenergic bronchodilator for both the acute and sustained treatment of asthma, and from the 1960s onward, the synthetic adrenergic agonists metaproterenol, albuterol (salbutamol), terbutaline, and others, given by the inhalation and oral routes, have also come into wide usage.

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Authors and Affiliations

  1. The Wellcome Research Laboratories Research, Triangle Park, North Carolina, USA

    Robert A. Maxwell

  2. University of Vermont College of Medicine, Burlington, Vermont, USA

    Shohreh B. Eckhardt

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Maxwell, R.A., Eckhardt, S.B. (1990). Albuterol. In: Drug Discovery. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0469-5_25

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  • DOI: https://doi.org/10.1007/978-1-4612-0469-5_25

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6775-1

  • Online ISBN: 978-1-4612-0469-5

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