Abstract
Nonsteroidal antiinflammatory drugs (NSAIDs) are used for the treatment of inflammation—a response to tissue injury already characterized in ancient times as consisting of redness, heat, swelling, and pain (Brune, 1984). This group of agents, which has aspirin as its prototype, shares several pharmacological properties, namely, antiinflammatory, antipyretic, and peripheral analgesic actions, all of which are useful for the relief of inflammation and pain (Shen, 1984).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bennett, D. R., ed.: AMA Drug Evaluations, 5th Ed., pp. 107–138, W. B. Saunders, Philadelphia, 1983.
Bird, H. A. and Wright, V.: Applied Drug Therapy of the Rheumatic Diseases, Wright PSG, Bristol, 1982.
Boardman, P.L.,and Hart, F.D.: Side-effects of indomethacin. Ann. Rheum. Dis. 26:127–132, 1967.
Brune, K.: The concept of inflammatory mediators, in Discoveries in Pharmacology, vol. 2, Haemodynamics, Hormones and Inflammation, M. J. Parnham and J. Bruinvels, eds., pp. 487–521, Elsevier, Amsterdam, 1984.
Calabro, J.J.: Long-term reappraisal of indomethacin. DrugTher. 5: 46–60, 1975.
Cochrane, G. M.: Systemic steroids in asthma, in Steroids in Asthma, T. Clark, ed., pp. 103–120, Adis, Auckland, 1983.
Collier, H. O. J.: The story of aspirin, in Discoveries in Pharmacology, vol. 2, Haemodynamics, Hormones and Inflammation, M. J. Parnham and J. Bruinvels, eds., pp. 555–593, Elsevier, Amsterdam, 1984.
Cooperating Clinics Committee of the American Rheumatism Association: A three month trial of indomethacin in rheumatoid arthritis, with special reference to analysis and inference. Clin. Pharmacol. Ther. 8:11–37, 1967.
Dreser, H.: Pharmakologisches über Aspirin (Acetylsalicylsäure). Pflügers Arch. Ges. Physiol. 76:306–318, 1899.
Flower, R. J., Moncada, S., and Vane, J. R.: Analgesic-antipyretics and antiinflammatory agents; drugs employed in the treatment of gout, in The Pharmacological Basis of Therapeutics, 7th Ed., A. G. Gilman, L. S. Goodman, T. W. Rail, and F. Murad, eds., pp. 674–715, Macmillan, New York, 1985.
Goodwin, J. S.: Immunologie effects of nonsteroidal antiinflammatory drugs. Am. J. Med. 77(4B), 7–15, 1984.
Hadler, N. M.: The argument for aspirin as the NSAID of choice in the management of rheumatoid arthritis. Druglntell. and Clin. Pharm.18:34–38, 1984.
Hart, F. D. and Boardman, P. L.: Indomethacin: A new non-steroid anti-inflammatory agent. Br. Med. J. 2:965–970, 1963.
Haynes, R. C. Jr. and Murad, F.: Adrenocorticotrophic hormone; adreno-cortical steroids and their synthetic analogs; inhibitors of adrenocortical steroid biosynthesis, in The Pharmacological Basis of Therapeutics, 7th Ed., A. G. Gilman, L. S. Goodman, T. W. Rail, and F. Murad, eds., pp. 1459–1489, Macmillan, New York, 1985.
Healey, L.A.: An appraisal of indomethacin. Bull. Rheum. Dis. 18:483–486, 1967.
Hench, P. S., Kendall, E. C., Slocumb, C. H., and Polley, H. F.: The effect of a hormone of the adrenal cortex (17-hydroxy-ll-dehydrocorticosterone: Compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis; preliminary report. Proc. Staff Mtg. Mayo Clinic 24:181–197, 1949.
Hess, E. V., and Tangnijkul, Y.: A rational approach to NSAID therapy. Ration. Drug Ther. 20:1–6, 1986.
Huskisson, E. C., ed.: Anti-Rheumatic Drugs, Praeger, Westport, CT, 1983.
Katz, W. A.: Modern management of rheumatoid arthritis. Am. J. Med. 79 (Suppl. 4C): 24–31, 1985.
Knorr, L.: Einwirkung von Acetessigester auf Hydrazinchinizinderivate. Chemische Berichte 17:546–552, 1884.
Meier, R., Schuler, W., and Desaulles, P.: Zur Frage des Mechanismus der Hemmung des Bindegewebswachstums durch Cortisone. Experientia 6: 469–471, 1950.
Mills, J. A.: Nonsteroidal anti-inflammatory drugs (in two parts). N. Engl. J. Med. 290: 781–784; 1002-1005,1974.
Norcross, B. M.: Treatment of connective tissue diseases with a new nonsteroidal compound (indomethacin). Arthritis Rheum. 6:290 (abs.), 1963.
O’Brien, W. M.: Indomethacin: a survey of clinical trials. Clin. Pharmacol. Ther. 9:94–107, 1968.
Rothermich, N. O.: Indomethacin: a new pharmacologie approach to the management of rheumatoid disease. Arthritis Rheum. 6:295 (abs.), 1963.
Shen, T. Y.: The proliferation of non-steroidal anti-inflammatory drugs (NS AIDs), in Discoveries in Pharmacology, vol. 2, Haemodynamics, Hormones and Inflammation. M. J. Parnham and J. Bruinvels, eds., pp. 523–553, Elsevier, Amsterdam, 1984
Shen, T. Y. and Winter, C. A.: Chemical and biological studies on indomethacin, sulindac and their analogs. Adv. Drug Res. 12:90–245, 1977.
Shen, T. Y., Windholz, T. B., Rosegay, A., Witzel, B. E., Wilson, A. N., Willet, J. D., Holtz, W. J., Ellis, R. L., Matzuk, A. R., Lucas, S., Stammer, C. H., Holly, F. W., Sarrett, L. H., Risley, E. A., Nuss, G. W., and Winter, C. A.: Nonsteroid anti-inflammatory agents. J. Am. Chem. Soc. 85: 488, 489, 1963.
Smyth, C.J.: Indomethacin—its rightful place in treatment (editorial). Ann. Intern. Med. 72:43(M32,1970.
Smyth, C. J., Velayos, E. E., and Amoroso, C.: A method for measuring swelling of hands and feet. Part II. Influence of new anti-inflammatory drug, indomethacin, in acute gout. Ada Rheum. Scand. 9:306–322, 1963.
Wilhelmi, G.: Ueber die pharmakologischen Eigenschaften von Irgapyrin, einem neuen Präparat aus der Pyrazolreihe. Schweiz. Med. Wochenschr. 79:577–582, 1949.
Wilhelmi, G.: Ueber die antiphlogistische Wirkung von Pyrazolen, speziell von Irgapyrin, bei peroraler und parenteraler Verabreichung. Schweiz. Med. Wochenschr. 80:936–942, 1950.
Winter, C. A. and Porter, C. C: Effect of alterations in side chain upon anti-inflammatory and liver glycogen activities of hydrocortisone esters. J. Am. Pharmaceut. Assoc. 46:515–519, 1957.
Winter, C. A., Risley, E. A., and Nuss, G. W.: Carrageenin-induced edema in hindpaw of the rat as an assay for antiinflammatory drugs. Proc. Soc. Exp. Biol. Med. 111: 544–547, 1962.
Winter, C. A., Risley, E. A., and Nuss, G. W.: Anti-inflammatory and antipyretic activities of indomethacin, l-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid. J. Pharmacol. Exp. Ther. 141:369–376, 1963.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer Science+Business Media New York
About this chapter
Cite this chapter
Maxwell, R.A., Eckhardt, S.B. (1990). Indomethacin. In: Drug Discovery. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0469-5_16
Download citation
DOI: https://doi.org/10.1007/978-1-4612-0469-5_16
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4612-6775-1
Online ISBN: 978-1-4612-0469-5
eBook Packages: Springer Book Archive