Abstract
Depression has been defined as “a sinking of spirits [affect] so as to constitute a clinically discernible condition” (Stedman, 1982). In earlier times, it was called melancholia. It comprises two major types: (1) severe depression of mood associated with psychomotor retardation or agitation, self-reproach or guilt, as well as other symptoms, all of which occur in the apparent absence of a precipitating cause; (2) severe depression of mood associated directly with an intensely sad external situation, which is relieved by removal of the external situation. The former is referred to as endogenous depression and the latter as reactive depression.
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References
Baldessarini, R. J.: Biomedical Aspects of Depression and its Treatment, American Psychiatric Press, Washington, DC, 1983.
Baldessarini, R. J.: Drugs and the treatment of psychiatric disorders, in The Pharmacologie Basis of Therapeutics, 7th Ed., A. G. Gilman, L. S. Goodman, T. W. Rail, F. Murad, eds., pp. 387–445, Macmillan, New York, 1985.
Charpentier, P.: Sur la constitution d’une dimethylamino-propyl-N-phéno-thiazine. Comptes Rendus 225:306–308, 1947.
Charpentier, P., Gaillot, P., Jacob, R., Gaudechon, J., and Buisson, P.: Chimie organique—Recherches sur les dimethylaminopropyl-N-phenothiazines substitutuee. Comptes Rendus 235, 59,60,1952.
Delay, J., Deniker, P., and Harl, J. M.: Utilisation en thérapeutique psychiatrique d’une phenothiazine d’action central elective (4560 R.P.) Ann. Méd.-Psychol. (Paris) 110:112–117, 1952a.
Delay, J., Deniker, P., and Harl, J. M.: Traitement des etats d’excitation et d’agitation par une méthode medicamenteuse d’erivee de l’hiberno-therapie. Ann. Méd.-Psychol. (Paris) 110:267–273, 1952b.
Häfliger, R: Chemistry of Tofranil. Can. Psychiatr. Assoc. 4: S69–S74, 1959.
Halpern, B. N.: Experimental research on a series of new chemical substances with powerful antihistaminic activity: The thiodiphenylamine derivatives. J. Allergy 18:263–272, 1947.
Hollister, L. E.: Tricyclic antidepressants. N.Engl.J.Med. 299:1106–1109, 1978.
Klein, D. F., Gittelman, R., Quitkin, F., and Rifkin, A.: Diagnosis and Drug Treatment of Psychiatric Disorders, 2nd Ed., Williams & Wilkins, Baltimore, 1980.
Klerman, G. L.: Drug therapy of clinical depressions—current status and implications for research on neuropharmacology of the affective disorders. J. Psychiatr. Res. 9:253–270, 1972.
Kuhn, R.: Über die Behandlung depressiver Zustände mit einem Imino-dibenzyl-derivat(G 22355). Schweiz. Med.Wochenschr. 35/36:1135–1140, 1957.
Kuhn, R.: The imipramine story, in Discoveries in Biological Psychiatry, F. J. Ayd and B. Blackwell, eds., pp. 205–217, Lippincott, Philadelphia, 1970.
Laborit, H.: Sur l’utilisation de certains agents pharmacodynamiques à action neuro-végétative en période per-et postoperatoire. Acta Chir. Belg. 48:485–492, 1949.
Laborit, H. and Leger, L.: Utilisation d’un antihistaminique de synthèse en thérapeutique pré, per, et post-opératoire. Presse Méd. 58:492, 1950.
Laborit, H., Huguenard, P., and Alluame, R.: Un nouveau stabilisateur vegetatif (le 4560 R. P.). Presse Méd. 60:206–208, 1952.
Lehmann, H.E.: Tricyclic antidepressants: Recollections by H. E.Lehmann, in Discoveries in Pharmacology, vol. 1, M. J. Parnhamand J. Bruinvels, eds., pp. 211–216, Elsevier, Amsterdam, 1983.
Schildkraut, J. J.: The catecholamine hypothesis of affective disorders; a review of supporting evidence. Am. J. Psychiatry 122:509–522, 1965.
Schildkraut, J. J. and Kety, S. S.: Biogenic amines and emotion. Science 156: 21–30, 1967.
Schindler, W. and Häfliger, F.: Über Derivate des Iminodibenzyls. Helv. Chim. Acta 37:472–483, 1954.
Stedman’s Medical Dictionary, 24th Ed., Williams & Wilkins, Baltimore, 1982.
Sulser, F. and Mishra, R.: The discovery of tricyclic antidepressants and their mode of action, inDiscoveries in Pharmacology, vol.1, M.J. Parnham and J. Bruinvels, eds., pp. 233–247, Elsevier, Amsterdam, 1983.
Sulser, F., Vetulani, J., and Mobley, P. L.: Mode of action of antidepressant drugs. Biochem. Pharmacol. 27:257–261, 1978.
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Maxwell, R.A., Eckhardt, S.B. (1990). Imipramine. In: Drug Discovery. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0469-5_10
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