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Drug and Hormonal Regulation of the Beta-Adrenergic Receptor—Adenylate Cyclase System

  • Chapter
The Beta-Adrenergic Receptors

Part of the book series: The Receptors ((REC))

Abstract

Catecholamines, acting through a variety of membrane-bound receptors, produce a wide range of physiological effects. Most mammalian organ systems are affected by either circulating or locally released epinephrine or norepinephrine. These agents produce their effects by interacting with two major classes of receptors, termed alpha-adrenergic and beta-adrenergic receptors. In this chapter, I shall deal exclusively with the beta-adrenergic receptor system. In 1967, Lands provided physiologic evidence for the existence of two subtypes of beta-adrenergic receptors, which he termed beta-1 and beta-2 (Lands et al., 1967). Subsequently, radioligand binding and biochemical analysis has confirmed the existence of these two subtypes (Stiles etal., 1984). This topic is covered in more detail in other chapters. It has become clear that both beta-1 and beta-2 adrenergic receptors stimulate the membrane-bound enzyme adenylate cyclase, thus increasing the intracellular concentration of cyclic AMP. Cyclic AMP appears to be the second messenger of beta-adrenergic agonists in all tissues examined (Sutherland and Rall, 1960).

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  1. Gary L. Stiles
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  1. Southwestern Medical Center at Dallas, The University of Texas, Dallas, Texas, USA

    John P. Perkins

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Stiles, G.L. (1991). Drug and Hormonal Regulation of the Beta-Adrenergic Receptor—Adenylate Cyclase System. In: Perkins, J.P. (eds) The Beta-Adrenergic Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0463-3_8

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  • DOI: https://doi.org/10.1007/978-1-4612-0463-3_8

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