Ethanol, Lipoprotein Metabolism, and Fatty Liver

  • M. R. Lakshman
  • Stuart J. Chirtel
  • Pradeep Ghosh
Part of the Drug and Alcohol Abuse Reviews book series (DAAR, volume 2)


Persistent excessive intake of ethanol can lead to liver cell injury and eventually to cirrhosis of the liver after prolonged abuse over many years. There are individual variations in susceptibility to alcohol toxicities. Hepatocellular necrosis results in a wide variety of clinical symptoms ranging from a relatively asymptomatic enlargement of the liver to massive fatty infiltration that ultimately leads to hepatic failure.1,2As the process of alcohol-mediated injury progresses, liver fibrosis and eventually cirrhosis ensue, resulting in total failure of the liver functions. The pathogenesis of alcohol-induced toxicity generally begins with specific episodes of hepatocellular injury accompanied by varying degrees of fatty liver.3As the alcohol abuse continues, this degenerative process manifests itself into liver cell dysfunction, chronic inflammation, and structural distortion leading to the proliferation of fibrous tissue, which ultimately culminates into the cirrhosis of the liver and death.


Fatty Liver Alcoholic Liver Disease Chronic Ethanol Plasma Free Fatty Acid Chylomicron Remnant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • M. R. Lakshman
  • Stuart J. Chirtel
  • Pradeep Ghosh

There are no affiliations available

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