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Alcohol and Hepatic Iron Homeostasis

  • Barry J. Potter
Part of the Drug and Alcohol Abuse Reviews book series (DAAR, volume 2)

Abstract

Alcoholic liver disease is associated with marked disorders of iron homeostasis. These abnormalities include changes in plasma iron turnover, 1 red cell iron incorporation, 1,2 depression of the serum levels of transferrin3 (the major serum iron transport protein), and, in approximately one-third of chronic alcoholics, an increase in liver iron concentrations. 4In the rat, ethanol alters the rate of synthesis and secretion of transferrin and other serum proteins by the liver. 5-7 Although these disturbances have been attributed to a variety of causes, such as a direct toxic effect of alcohol on heme synthesis,8 negative vitamin balance, 2altered iron absorption,9-11 or intake of greater quantities of iron contained in some alcoholic beverages,12,13 the mechanism(s) of these disorders remain(s) in doubt.

Keywords

Iron Absorption Serum Ferritin Iron Overload Iron Uptake Serum Iron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    D. L. Beaumier, M. A. Caldwell, and B. E. Holdbein (1984) Inflammation triggers hypoferremia and ceruloplasmin in mice. Infect. Immun. 46,489–494.PubMedGoogle Scholar
  2. 2.
    E. R. Eichner and R. S. Hillman (1971) The evolution of anemia in alcoholic patients. Am. J. Med 50, 218–232.PubMedCrossRefGoogle Scholar
  3. 3.
    L. S. Valberg, C. N. Ghent, D. A. Lloyd, J. V. Frei, and M. J. Chamberlain (1978) Diagnostic efficacy of tests for the detection of iron overload. Canad. Med. Assoc. J. 119, 229–236.PubMedGoogle Scholar
  4. 4.
    R. W. Chapman, M. Y. Morgan, M. Laulicht, A. V. Hoffbrand, and S. Sherlock (1982) Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis. Dig. Dis. Sci. 27, 909–916.Google Scholar
  5. 5.
    E. Baraona, P. Pikkarainen, M. Salaspuro, F. Finkelman, and C. S. Lieber (1980) Acute effects of ethanol in hepatic protein synthesis and secretion in the rat. Gastroenterology 79,104–111.PubMedGoogle Scholar
  6. 6.
    K. N. Jeejeebhoy, M. J. Phillips, A. Bruce-Robertson, J. Ho, and V. Sodtke (1972) The effect of cortisol on the synthesis of rat plasma albumin, fibrinogen and transfenin. Biochem. J. 130, 533–538.PubMedGoogle Scholar
  7. 7.
    S. Mookerjea and A. Chow (1969) Impairment of glycoprotein synthesis in acute ethanol. Biochim. Biophys. Acta 184, 83–92.Google Scholar
  8. 8.
    D. O. B. Hourihane and D. G. Weir (1970) Suppression of erythropoiesis by alcohol. Br. Med J. 1, 86–89.PubMedCrossRefGoogle Scholar
  9. 9.
    A. E. Davis and J. Badendock (1962) Iron absorption in pancreatic disease. Lancet ii, 5–8.Google Scholar
  10. 10.
    R. W. Charlton, P. Jacobs, M. Seftel, and T. M. Bothwell (1964) Effects of alcohol on iron absortion. Br. Med J. 2,1427–1429.PubMedCrossRefGoogle Scholar
  11. 11.
    E. W. Sorensen (1966) Studies on iron absorption. Acta Med. Scand. 180, 241–244.Google Scholar
  12. 12.
    E. B. Flink (1971) Mineral metabolism in alcoholism, in The Biology of Akoholism, vol. 1. B. Kissin and M. Begleiter, eds. Plenum, London, pp. 377–395.Google Scholar
  13. 13.
    J. P. von Wartburg and J. Papenberg (1970) Biochemical and enzymatic changes induced by chronic ethanol intake, in International Encyclopedia of Pharmacology and Therapeutics, vol 22. J. Tremolieres, ed. Pergamon, Oxford, pp. 301–343.Google Scholar
  14. 14.
    M. E. Conrad and J. E. Barton (1980) Anemia and iron kinetics in alcoholism. Semin. Hematol. 17, 149–163.Google Scholar
  15. 15.
    C. Kimber, D. J. Deller, R. N. Ibbotson, and H. Lander (1965) The mechanism of anemia in chronic liver disease. Q. J. Med. 34, 33–64.Google Scholar
  16. 16.
    N. Krasner, K. M. Cochran, R. I. Russel, H. A. Carmichael, and G. C. Thompson (1976) Alcohol and absorption from the small intestine. 1. Impairment of absorption from the small intestine in alcoholics. Gut 17, 245–248.PubMedCrossRefGoogle Scholar
  17. 17.
    B. Speck (1970) Die tagesschwankungen des serumeisens und der latenten eisenbindungskapazitat dei hepatitis, leberzirrhose, alkoholismus, hamcchromatose und aplastischer anamie. Schweiz Med. Wochenshr. 100, 303–305.Google Scholar
  18. 18.
    I. M. Friedman, H. C. Kraemer, F. S. Mendoza, and L. D. Hammer (1988) Elevated serum iron concentration in adolescent alcohol users. Am. J. Dis. Children 142,156–159.Google Scholar
  19. 19.
    J. Linderbaum and C. S. Lieber (1969) Hematologic effects of alcohol in man in the absence of nutritional deficiency. N. Engl. J. Med. 281, 333–338.CrossRefGoogle Scholar
  20. 20.
    Y Hofvander (1968) Haematological investigations in Ethiopia with special reference to a high iron intake. Acta Med. Scand Suppl. 494,1–74.Google Scholar
  21. 21.
    A. R. P. Walker and V.B. Arvidsson (1953) Iron overload in the South African Bantu. Trans. Roy. Soc. Trop. Med. Hyg. 47,536–548.Google Scholar
  22. 22.
    T. H. Bothwell, R. W. Charlton, and H. C. Seftel (1965) Oral iron overload. S. Aft. Med J. 39, 892–900.Google Scholar
  23. 23.
    L. D. Baker (1986) Alcohol consumption among South African blacks and its relationship to iron overload. S. Aft. Med J. 70,160–62.Google Scholar
  24. 24.
    C. Isaacson (1978) The changing pattern of liver disease in South African Blacks. S. Afr. Med J. 53,365–368.Google Scholar
  25. 25.
    M. Simon, M. Bourci, B. Genetet, and R. Fauchet (1977) Idiopathic hemochromatosis: Demonstration of recessive transmission and early detection by family HLA typing. N. Engl. J. Med. 297,1017–1021.PubMedCrossRefGoogle Scholar
  26. 26.
    A. Bomford, A. J. Eddleston, L.A. Kennedy, J. R. Batchelor, and R. Williams (1977) Histocompatability antigens as markers of abnormal iron metabolism in patients with idiopathic haemochromatosis and their relatives. Lancet i, 327–329.Google Scholar
  27. 27.
    G. E. Cartwright, C. Q. Edwards, K. Kravitz, M. Skolknick, D. B. Amos, A. Johnson, and L. Buskgaer (1979) Hereditary hemochromatosis: Phenotypic expression of the disease. N. Engl. J. Med. 301,175–179.PubMedCrossRefGoogle Scholar
  28. 28.
    T. H. Bothwell and R. W. Charlton (1982) A general approach to the problems of iron deficiency and iron overload in the population at large. Semin. Hematol.19, 54–67.Google Scholar
  29. 29.
    T. E. Meyer, D. Ballot, T. H. Bothwell, A. Green, D. P. Derman, R. D. Baynes, T. Jenkins, P. L. Jooste, E. D. Du Toits, and R Jacobs (1987) The HLA linked iron loading gene in an Afrikaner population. J. Med. Genet. 24, 48–353.CrossRefGoogle Scholar
  30. 30.
    R. A. MacDonald (1961) Idiopathic hemochromatosis, a variant of portal cirrhosis and idiopathic hemosiderosis. Arch. Intern. Med. 107, 606–616.Google Scholar
  31. 31.
    L. W. Powell (1975) The role of alcoholism in hepatic iron storage disease. Ann. NYAcad Sci. 252,124–134.CrossRefGoogle Scholar
  32. 32.
    M. Simon, M. Bourel, B. Genetet, R. Fauchet, G. Edan, and P. Brissot (1977) Idiopathic hemochromatosis and iron overload in alcoholic liver disease: Differentiation by HLA phenotype. Gastroenterology 73, 655–658.PubMedGoogle Scholar
  33. 33.
    M. Simon, J.-L. Alexandre, M. Bourel, B. Le Marec, and C. Scordia (1977) Heredity of idiopathic haemochromatosis: A study of 106 families. Clin. Genet. 11, 327–341.Google Scholar
  34. 34.
    D. Conte, A. Pipemo, C. Mandeli, S. Fargion, M. Cesana, L. Brunelli, L. Ferrario, P. Velio, M. G. Zaramella, C. Tnibelli, G. Fiorelli, and P. A. Bianchi (1986) Clinical, biochemical and histological features of primary haemochromatosis: A report of 67 cases. Liver 6, 310–315.PubMedGoogle Scholar
  35. 35.
    P. Brissot, M. Bourel, D. Herry, J.-P. Verger, M. Messner, C. Beaumont, F. Regnouard, B. Ferrand, and M. Simon (1981) Assessment of liver iron content in 271 patients: A reevaluation of direct and indirect methods. Gastroenterology 80, 557–565.PubMedGoogle Scholar
  36. 36.
    L. Hallberg, A.-M. Hogdahl, L. Nilsson, and G. Rybo (1966) Menstrual blood loss and iron deficiency. Acta Med. Scand. 180, 639–650.PubMedCrossRefGoogle Scholar
  37. 37.
    S. K. Cole, W. Z. Billewicz, and A. M. Thomson (1971) Source of variation in menstrual blood loss. J. Obstet. Gynaecol. Br. Commonwealth 78, 933–939.CrossRefGoogle Scholar
  38. 38.
    M. Layrisse and C. Martinez-Torres (1971) Food iron absorption: Iron supplementation of food, in Progress in Hematology, vol VI. E. B. Brown and C. V. Moore, eds. Grune and Stratton, New York, pp. 137–160.Google Scholar
  39. 39.
    W. Forth and W. Rummel (1973) Iron absorption. Physiol. Rev. 53, 724–792.Google Scholar
  40. 40.
    T. H. Bothwell, G. Pirzio-Biroli, and C. A. Finch (1958) Iron absorption. I. Factors influencing absorption. J. Lab. Clin. Med. 51, 24–36.PubMedGoogle Scholar
  41. 41.
    A. Jacobs and P. M. Miles (1969) Intraluminal transport of iron from stomach to small intestinal mucosa. Br. Med J. iv, 778–781.Google Scholar
  42. 42.
    P. M. Smith, F. Studley, and R. Williams (1969) Postulated gastric factor enhancing iron absorption in haemochromatosis. Br. J. Haematol. 16, 443–449.PubMedCrossRefGoogle Scholar
  43. 43.
    L. W. Powell and E. Wilson (1970) In vivo intestinal mucosal uptake of iron, body iron absorption and gastric juice iron-binding in idiopathic haemochromatosis. Austral. Ann. Med. 19, 226–231.Google Scholar
  44. 44.
    A. Jacobs and P. M. Miles (1968) The iron-binding properties of gastric juice. Clin. Chim. Acta. 24, 87–92.Google Scholar
  45. 45.
    M. S. Wheby, M. E. Conrad, S. E. Hedberg, and W. H. Crosby (1962) The role of bile in the control of iron absorption. Gastroenterology 42, 319–324.PubMedGoogle Scholar
  46. 46.
    D. A. Webling and E. S. Holdsworth (1966) Bile and the absorption of strontium and iron. Biochem. J.100, 661–663.PubMedGoogle Scholar
  47. 47.
    H. Brise (1962) Effect of surface-active agents on iron absorption. Acta Med. Scand. 171 (Suppl. 376), 47–50.Google Scholar
  48. 48.
    M. S. Wheby, L. G. Jones, and W. H. Crosby (1964) Studies on iron absorption. Intestinal regulatory mechanisms. J. Clin. Invest. 43,1433–1442.PubMedCrossRefGoogle Scholar
  49. 49.
    M. S. Wheby (1970) Site of iron absorption in man. Scand J. Haematol. 7, 56–62.Google Scholar
  50. 50.
    B. S. Narasinga Rao (1981) Physiology of iron absorption and supplementation. Br. Med. Bull. 37, 25–30.Google Scholar
  51. 51.
    A. Muir and U. Hopfer (1985) Regional specificity of iron uptake by small intestinal brush-border membranes from normal and iron deficient mice. Am. J. Physiol. 248, G376–G379.PubMedGoogle Scholar
  52. 52.
    K. B. Raja, I. Bjarnason, R. J. Simpson, and T. J. Peters (1987) In vitro measurement and adaptive response of Fei+ uptake by mouse intestine. Cell. Biochem. Function. 5,69–76.Google Scholar
  53. 53.
    M. A. Savin and J. D. Cook (1978) Iron transport by isolated rat intestinal mucosal cells. Gastroenterology 75, 688–694.PubMedGoogle Scholar
  54. 54.
    T. M. Cox and M. W. O’Donnell (1981) Studies on the binding of iron by rabbit intestinal microvillous membranes. Biochem. J. 194, 753–759.PubMedGoogle Scholar
  55. 55.
    J. J. M. Marx and P. Aisen (1981) Iron uptake by rabbit intestinal mucosal membrane vesicles. Biochim. Biophys. Acta 649, 297–304.CrossRefGoogle Scholar
  56. 56.
    R. J. Simpson and T. J. Peters (1984) Studies of Fe3+ transport across isolated intestinal brush-border membrane of the mouse. Biochim. Biophys. Acta 772, 220–226.CrossRefGoogle Scholar
  57. 57.
    R. J. Simpson, K. B. Raja, and T. J. Peters (1985) Fe3+ transport by brush-border membrane vesicles isolated from normal and hypoxic mouse duodenum and ileum. Biochim. Biophys. Acta 814, 8–12.CrossRefGoogle Scholar
  58. 58.
    R. J. Simpson and T. J. Peters (1985) Fe2+ uptake by intestinal brush-border membrane vesicles from normal and hypoxic mice. Biochim. Biophys. Acta 814, 381–388.PubMedCrossRefGoogle Scholar
  59. 59.
    R. J. Simpson and T. J. Peters (1986) pH-sensitive transport of Fe2+ across purified brush-border membrane from mouse intestine. Biochim. Biophys. Acta 856,109–114.Google Scholar
  60. 60.
    R. J. Simpson and T. J. Peters (1986) Cholate-soluble and -insoluble iron binding components of rabbit duodenal brush-border membrane. Relevance to Fe2+ uptake by brush border membrane vesicles. Biochim. Biophys. Acta 859, 227–236.Google Scholar
  61. 61.
    R. J. Simpson and T. J. Peters (1987) Transport of Fe2+ across lipid bilayers: Possible role of free fatty acids. Biochim. Biophys. Acta 898,187–195.Google Scholar
  62. 62.
    P. E. Johnson, H. C. Lukaski, and T. D. Bowman (1987) Effects of level and saturation of fat and iron level and type in the diet on iron absorption and utilization by the rat. J. Nutr. 117, 501–507.PubMedGoogle Scholar
  63. 63.
    M. W. O’Donnell and T. M. Cox (1982) Microvillar iron-binding glycoproteins isolated from the rabbit small intestine. Biochem. J. 202,107–115.PubMedGoogle Scholar
  64. 64.
    W. N. Pearson and M. Reich (1969) Studies of ferritin and a new iron-binding protein found in the intestinal mucosa of the rat. J. Nutr. 99, 137–140.PubMedGoogle Scholar
  65. 65.
    M. Worwood and A. Jacobs (1971) Absorption of 59Fe in the rat: Iron binding substances in the soluble fraction of intestinal mucosa. Life Sci. 10,1363–1373.CrossRefGoogle Scholar
  66. 66.
    S. Pollack and F. D. Lasky (1976) A new iron-binding protein isolated from intestinal mucosa. J. Lab. Clin. Med. 87, 670–679.PubMedGoogle Scholar
  67. 67.
    H. Huebers, E. Huebers, W. Rummel, and R. C. Crichton (1976) Isolation and characterization of iron-binding proteins from rat intestinal mucosa. Eur. J. Biochem. 66, 447–455.PubMedCrossRefGoogle Scholar
  68. 68.
    J. W. Halliday, L. W. Powell, and U. Mack (1976) Iron absorption in the rat The search for possible intestinal mucosal carriers. Br. J. Haematol. 34, 237–250.PubMedCrossRefGoogle Scholar
  69. 69.
    G. Johnson, P. Jacobs, and L. R. Purves (1983) Iron binding proteins of iron-absorbing rat intestinal mucosa. J. Clin. Invest. 71,1467–1476.PubMedCrossRefGoogle Scholar
  70. 70.
    R. G. Sheehan and E. P. Frenkel (1972) The control of iron absorption by the gastrointestinal mucosal cell. J. Clin. Invest. 51, 224–231.PubMedCrossRefGoogle Scholar
  71. 71.
    M. C. Linder, V. Dunn, E. Isaacs, D. Jones, M. Van Volkom, and H. N. Munro (1975) Ferritin and intestinal iron absorption: Pancreatic enzymes and free iron. Am. J. Physiol. 228,196–201.PubMedGoogle Scholar
  72. 72.
    J. A. Smith, J. W. Drysdale, A. Goldberg, and H. N. Munro (1968) The effect of enteral and parenteral iron on ferritin synthesis in the intestinal mucosa of the rat. Br. J. Haematol. 14, 79–86.PubMedCrossRefGoogle Scholar
  73. 73.
    M. A. Savin and J. D. Cook (1980) Mucosal iron transport by rat intestine. Blood 56,1029–1035.PubMedGoogle Scholar
  74. 74.
    H. A. Huebers, E. Huebers, E. Csiba, W. Rummel, and C. A. Finch (1983) The significance of transferrin for intestinal iron absorption. Blood 61, 283–290.PubMedGoogle Scholar
  75. 75.
    K. Osterloh, K. Schuman, C. Ehtechami, and W. Forth (1985) Transferrin in isolated cells from rat duodenum and jejunum. Blut 51, 41–47.PubMedCrossRefGoogle Scholar
  76. 76.
    G. Johnson, P. Jacobs, and L. R Purves (1985) The effects of cytoskeletal inhibitors on intestinal iron absorption in the rat. Biochim. Biophys. Acta 843, 83–91.Google Scholar
  77. 77.
    R. B. Dawson, S. Rafal, and L. R Weintraub (1970) Absorption of hemoglobin iron: The role of xanthine oxidase in the intestinal, heme-splitting reaction. Blood 35, 94–103.PubMedGoogle Scholar
  78. 78.
    R. W. Topham, J. H. Woodruff, and M. C. Walker (1981) Purification and characterization of the intestinal promoter of Fei+-transferrin formation. Biochemistry 20, 319–324.PubMedCrossRefGoogle Scholar
  79. 79.
    J. Fletcher and E. R. Huehns (1968) Function of transferrin. Nature 218, 1211–1214.PubMedCrossRefGoogle Scholar
  80. 80.
    O. Zak and P. Aisen (1990) Evidence for functional differences between the two sites of rabbit transferrin: Effects of serum and carbon dioxide. Biochim. Biophys. Acta 1052, 24–28.Google Scholar
  81. 81.
    J. J. Marx, J. A. G. K. Gebbink, T. Nishisato, and P. Aisen (1982) Molecular aspects of the binding of absorbed iron to transferrin. Br. J. Haematol. 52, 105–110.PubMedCrossRefGoogle Scholar
  82. 82.
    H. A. Huebers, B. Josephson, E. Huebers, E. Csiba, and C. A. Finch (1984) Occupancy of the iron binding sites of transferrin. Proc. Natl. Acad. Sci. USA 81, 4326–4330.PubMedCrossRefGoogle Scholar
  83. 83.
    O. Zak and P. Aisen (1986) Nonrandom distribution of iron in circulating transferrin. Blood 68,157–161.PubMedGoogle Scholar
  84. 84.
    J. Williams and K. Moreton (1980) The distribution of iron between the metal-binding sites of transferrin in human serum. Biochem. J. 185, 483–488.PubMedGoogle Scholar
  85. 85.
    M. Cazzola, H. A. Huebers, M. H. Sayers, A. P. MacPhail, M. Eng, and C. A. Finch (1985) Transferrin saturation, plasma iron turnover, and transferrin uptake in normal humans. Blood 66, 935–939.PubMedGoogle Scholar
  86. 86.
    R A. Seligman (1983) Structure and function of the transferrin receptor, in Progress in Hematology, vol XIII. E. B. Browm, ed. Grune and Stratton, New York, pp. 131–146.Google Scholar
  87. 87.
    W. S. May, Jr and R Cuatrecasas (1985) Transferrin receptor: Its biological significance. J. Membrane Biol. 88, 205–215.CrossRefGoogle Scholar
  88. 88.
    I. S. Trowbridge and M. B. Omary (1981) Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin. Proc. Natl. Acad. Sci. USA 78, 3039–3043.PubMedCrossRefGoogle Scholar
  89. 89.
    C. A. Enns and H. H. Sussman (1981) Physical characterization of the transferrin receptor in human placentae. J. Biol. Chem. 256, 9820–9823.PubMedGoogle Scholar
  90. 90.
    M. B. Omary and I. S. Trowbridge (1981) Covalent binding of fatty acid to the transferrin receptor in cultured human cells. J. Biol. Chem. 256, 4715–4718.PubMedGoogle Scholar
  91. 91.
    C. Schneider, R. Sutherland, R. Newman, and M. Greaves (1982) Structural features of the cell surface receptor for transferrin that is recognized by the monoclonal antibody OKT9. J. Biol. Chem. 257, 8516–8522.PubMedGoogle Scholar
  92. 92.
    E M. van Bockxmeer and E. H. Morgan (1979) Transferrin receptors during rabbit reticulocyte maturation. Biochim. Biophys. Acta 584, 76–83.Google Scholar
  93. 93.
    J. H. Jandl and J. H. Katz (1963) The plasma-to-cell cycle of transferrin. J. Clin. Invest. 42, 314–326.PubMedCrossRefGoogle Scholar
  94. 94.
    Z. Zaman, M. Heynen, and R. L. Verwilgen (1980) Studies on the mechanism of transferrin iron uptake by reticulocytes. Biochim. Biophys. Acta 632, 553–561.Google Scholar
  95. 95.
    C. Harding, J. Meuser, and R Stahl (1983) Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J. Cell Biol. 97, 329–339.PubMedCrossRefGoogle Scholar
  96. 96.
    C. R. Hopkins and I. S. Trowbridge (1983) Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells. J. Cell Biol. 97, 508–521.PubMedCrossRefGoogle Scholar
  97. 97.
    J. A. Hanover, M. C. Willingham, and I. Paston (1984) Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes. Cell 39,283–293.PubMedCrossRefGoogle Scholar
  98. 98.
    P Aisen and L. Listowsky (1980) Iron transport and storage proteins. Ann. Rev. Biochem. 49, 357–393.PubMedCrossRefGoogle Scholar
  99. 99.
    A. Dautry-Varsat, A. Ciechanover, and H. F. Lodish (1983) pH and the recycling of transferrin during receptor-mediated endocytosis. Proc. Natl. Acad Sci. USA 80,2258–2262.PubMedCrossRefGoogle Scholar
  100. 100.
    R. D. Klausner, G. Ashwell, J. van Renswoude, J. B. Harford, and K. R. Bridges (1983) Binding of apotransferrin to K562 cells: Explanation of the transferrin cycle. Proc. Natl. Acad Sci. USA 80,2263–2266.PubMedCrossRefGoogle Scholar
  101. 101.
    A. Ciechanover, A. L. Schwartz, A. Dautry-Varsat, and H. E Lodish (1983) Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. J. Biol. Chem. 258,9681–9689.PubMedGoogle Scholar
  102. 102.
    K. Konopka and I. Romslo (1980) Uptake of iron from transferrin by isolated rat mitochondria mediated by phosphate compounds. Eur. J. Biochem.107, 433–439.PubMedCrossRefGoogle Scholar
  103. 103.
    K. K. Rao, J. B. Harford, T. Rouault, A. McClelland, E H. Ruddle, and R. D. Klausner (1986) Transcriptional regulation by iron of the gene for the transferrin receptor. Mol. Cell. Biol. 6,236–240.Google Scholar
  104. 104.
    J. L. Casey, B. Di Jeso, K. Rao, R. D. Klausner, and J. B. Harford (1988) Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor. Proc. Natl. Acad Sci. USA 85,1787–1791.PubMedCrossRefGoogle Scholar
  105. 105.
    C. A. Enns, H. A. Suomalainen, J. E. Gebhardt, J. Scroder, and H. H. Sussman (1982) Human transferrin receptor: Expression of the receptor is assigned to chromosome 3. Proc. Natl. Acad. Sci. USA 79,3241–3245.PubMedCrossRefGoogle Scholar
  106. 106.
    R. M. Nunes, O. Beloqui, B. J. Potter, and P. D. Berk (1986) Evidence for receptor mediated uptake of transferrin iron by rat hepatocytes. Ann. NYAcad. Sci. 463,327–329.CrossRefGoogle Scholar
  107. 107.
    S. P. Young and P. Aisen (1981) Transferrin receptors and the uptake and release of iron by isolated hepatocytes. Hepatology 1,114–119.PubMedCrossRefGoogle Scholar
  108. 108.
    S. P. Young and P. Aisen (1980) The interaction of transferrin with isolated hepatocytes. Biochim. Biophys. Acta 633,145–153.Google Scholar
  109. 109.
    R. M. Nunes, J. M. Prieto, and B. J. Potter (1982) Mediation of a receptor mechanism in the uptake of iron from transferrin by the hepatocyte. Protides Biol. Fluids 29,455–458.Google Scholar
  110. 110.
    O. Beloqui, R. M. Nunes, B. Blades, P. D. Berk, and B. J. Potter (1986) Depression of iron uptake from transferrin by isolated hepatocytes in the presence of ethanol is a pH-dependent consequence of ethanol metabolism. Alcohol. Clin. Exp. Res. 10,463–470.Google Scholar
  111. 111.
    E. H. Morgan and E. Baker (1986) Iron uptake and metabolism by hepatocytes. Fed. Proc. 45, 2810–2816.PubMedGoogle Scholar
  112. 112.
    R. Soda and M. Tavassoli (1984) Liver endothelium and not hepatocytes or Kupffer cells have transferrin receptors. Blood 63, 270–276.PubMedGoogle Scholar
  113. 113.
    W. Vogel, A. Bomford, S. Young, and R. Williams (1987) Heterogeneous distribution of transferrin receptors on parenchymal and nonparenchymal liver cells: Biochemical and morphological evidence. Blood 69, 264–270.PubMedGoogle Scholar
  114. 114.
    T. Kishimoto and M. Tavassoli (1986) Recovery of transferrin receptors on hepatocytes membranes after collagenase perfusion. Biochem. Biophys. Res. Commun. 134, 711–715.Google Scholar
  115. 115.
    J.-C. Sibille, J.-N. Octave, Y.-J. Schneider, A. Trouet, and R. R. Crichton (1982) Transferrin protein and iron uptake by cultured hepatocytes. FEBS Len. 150, 365–369.CrossRefGoogle Scholar
  116. 116.
    C. G. D. Morley and A. Bezkorovainy (1983) The behavior of transferrin receptors in rat hepatocyte plasma membranes. Clin. Physiol. Biochem. 1, 318–328.Google Scholar
  117. 117.
    M. A. Page, E. Baker, and E. H. Morgan (1984) Transferrin and iron uptake by rat hepatocytes in culture. Am. J. Physiol. 246, G26–G33.PubMedGoogle Scholar
  118. 118.
    C. G. D. Morley and A. Bezkorovainy (1985) Cellular iron uptake from transferrin: Is endocytosis the only mechanism? Int. J. Biochem.17, 553–564.PubMedCrossRefGoogle Scholar
  119. 119.
    C. Watts (1985) Rapid endocytosis of the transferrin receptor in the absence of bound transferrin. J. Cell Biol. 100, 633–637.PubMedCrossRefGoogle Scholar
  120. 120.
    J. W. Drysdale and H. N. Munro (1966) Regulation of synthesis and turnover of ferritin in rat liver. J. BioL Chem. 241, 3630–3637.PubMedGoogle Scholar
  121. 121.
    J. Rogers and H. N. Munro (1987) Translation of ferritin light and heavy subunit mRNA’s is regulated by intracellular chelatable iron levels in rat hepatoma cells. Proc. Natl. Acad. Sci. USA 84, 2277–2281.PubMedCrossRefGoogle Scholar
  122. 122.
    A. Rouault, M. W. Hentze, A. Danas, W. Caughman, J. B. Harford, and R. D. Klausner (1987) Influence of altered transcription on the translational control of human ferritin expression. Proc. Natl. Acad. Sci. USA 84, 6335–6339.PubMedCrossRefGoogle Scholar
  123. 123.
    T. A. Rouault, M. W. Hentze, S. W. Caughman, J. B. Harford, and R. D. Klausner (1988) Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA. Science 241,1207–1210.PubMedCrossRefGoogle Scholar
  124. 124.
    T. C. lancu and H. B. Neustein (1977) Ferritin in human liver cells of homozygous beta-thalassemia: Ultrastructural observations. Br. J. Haematol. 37, 527–535.CrossRefGoogle Scholar
  125. 125.
    C. A. Seymor and T. J. Peters (1978) Organelle pathology in primary and secondary haemochromatosis with special reference to lysosomal changes. Br. J. Haematol. 40, 239–253.CrossRefGoogle Scholar
  126. 126.
    B Model (1979) Advances in the use or iron-chelating agents for the treatment of iron overload, in Progress in Hematology, vol XI. E. B. Brown, ed. Grune and Stratton, New York, pp. 267–312.Google Scholar
  127. 127.
    D. A. Lipschitz, T. H. Bothwell, H. C. Seftel, A. C. Wapnick, and R. W. Charlton (1971) The role of ascorbic acid in the metabolism of storage iron. Br. J. Haematol. 20,155–163.PubMedCrossRefGoogle Scholar
  128. 128.
    E. Baker, A. G. Morton, and A. S. Tavill (1980) The regulation of iron release from the perfused liver. Br. J. Haematol. 45, 607–620.PubMedCrossRefGoogle Scholar
  129. 129.
    U. Mack, L. W. Powell, and J. W. Halliday (1983) Detection and isolation of a hepatic membrane receptor for ferritin. J. Biol. Chem. 258, 4672–4675.PubMedGoogle Scholar
  130. 130.
    T. A. Hamilton, P. W. Gray, and D. O. Adams (1984) Expression of the transferrin receptor on murine peritoneal macrophages is modulated by in vitro treatment with interferon gamma. Cell. Immunol. 89, 478–488.Google Scholar
  131. 131.
    R. Andreesen, J. Osterholz, H. Bodemann, K. J. Bross, U. Costabel, and G. W. Lohr (1984) Expression of transferrin receptors and intracellular ferritin during terminal differentiation of human monocytes. Blut 49, 195–202.PubMedCrossRefGoogle Scholar
  132. 132.
    N. Colman and V. Herbert (1980) Hematologic complications of alcoholism: Overview. Semin. Hematol.17,164–176.Google Scholar
  133. 133.
    M. Myrhed, L. Berglund, and L. E. Bottiger (1977) Alcohol consumption and hematology. Acta Med Scand. 202,11–15.PubMedCrossRefGoogle Scholar
  134. 134.
    R. W. Charlton, P. Jacobs, H. Seftel, and T. H. Bothwell (1964) Effects of alcohol on iron absorption. Br. Med J. 2,1427–1429.PubMedCrossRefGoogle Scholar
  135. 135.
    A. Celada, H. Rudolf, and A. Donath (1978) Effect of a single ingestion of alcohol on iron absorption. Am. J. Hematol. 5, 225–237.PubMedCrossRefGoogle Scholar
  136. 136.
    R. A. MacDonald and G. S. Pechet (1964) Absorption by rats of iron in wine. Proc. Soc. Exp. Biol. Med 117,54–56.PubMedGoogle Scholar
  137. 137.
    E. J. Tapper, S. Bushi, R. D. Ruppert, and N.J. Greenberger (1968) Effect of acute and chronic ethanol treatment on the absorption of iron in rats. Am. J. Med. Sci. 255, 46–52.PubMedCrossRefGoogle Scholar
  138. 138.
    R Mazzanti, K. S. Srai, E. S. Debnam, A. M. Boss, and P. Gentilini (1987) The effect of chronic ethanol consumption on iron absorption in rats. Alcohol Alcohol. 22, 47–52.PubMedGoogle Scholar
  139. 139.
    S. J. Fairweather-Tait, S. Southon, and Z. Piper (1988) The effect of alcoholic beverages on iron and zinc metabolism in the rat. Br. J. Nutt: 60, 2Q-215.Google Scholar
  140. 140.
    J. Lindenbaum (1980) Folate and vitamin B12 deficiencies in alcoholism. Semin. Hematol.17,113–118.Google Scholar
  141. 141.
    A. Celada, H. Rudolf, and A. Donath (1979) Effects of experimental chronic alcohol ingestion and folic acid deficiency on iron absorption. Blood 54, 906–915.PubMedGoogle Scholar
  142. 142.
    F. El-Shobaki and W. Rummel (1985) Mucosal iron binding proteins aand the inhibition of iron absorption by endotoxin. Blut 50, 95–101.PubMedCrossRefGoogle Scholar
  143. 143.
    P. Whittaker, B. S. Skikne, A. M. Covell, C. Flowers, A. Cooke, S. R. Lynch, and J. D. Cook (1989) Duodenal iron proteins in idiopathic hemochromatosis. J. Clin. Invest. 83, 261–267.PubMedCrossRefGoogle Scholar
  144. 144.
    R. W. Topham, S. A. Joslin, and J. S. Prince Jr (1985) The effect of short term exposure to low iron diets on the mucosal processing of ionic iron. Biochem. Biophys. Res. Commun. 133, 1092–1G57.PubMedCrossRefGoogle Scholar
  145. 145.
    G. J. Anderson, L. W. Powell, and J. W. Halliday (1990) Transferrin receptor distribution and regulation in the rat small intestine. Effect of iron stores and erythropoiesis. Gastroenterology 98, 576–585.PubMedGoogle Scholar
  146. 146.
    A. Gilbert and A. Gernet (1896) Cirrhose alcoolique hypertrophique pigmentaire. Com. Rend Acad Sci. (Paris) 3,1078–1081.Google Scholar
  147. 147.
    J. Lereboullet, R. Levillain, and B. Debesse (1956) L’hepatosiderose. Sa frequence chez les alcooliques, etudes statistique de 350 examens anatomique. Bull. Mem. Soc. Med. Hop. Paris 72,684–689.PubMedGoogle Scholar
  148. 148.
    J. Andre (1961) Le demembrement des hemachromatosis. Rev. Int. Hepatol. 11,113–174.PubMedGoogle Scholar
  149. 149.
    M. Barry (1973) Iron and chronic liver disease. J. Royal Coll. Physicians 8, 52–62.Google Scholar
  150. 150A.
    W. Jakobovits, M. Y. Morgan, and S. Sherlock (1979) Hepatic siderosis in alcoholics. Dig. Dis. Sci. 24, 305–310.Google Scholar
  151. 151.
    J M. Miralles Garcia and S. de Castro del Pozo (1976) Iron deposits in chronic alcoholics. Special studies in relation to the iron contained in red wine. Acta Hepatogastroenterol. 23,10–19.Google Scholar
  152. 152.
    L. W. Powell (1966) Normal human iron storage and its relation to etnanol consumption. Australas Ann. Med. 15,110–115.Google Scholar
  153. 153.
    O. Lundvall, A. Weinfeld, and R Lundin (1969) Iron stores in alcohol abusers.I. Liver iron. Acta Med Scand 185, 259–269.PubMedCrossRefGoogle Scholar
  154. 154.
    G. S. Pechet, S. W. French, J. Levy, and R. A. MacDonald (1965) Histologic and chemical tissue iron. Arch. Pathol. 79,452–461.Google Scholar
  155. 155.
    A. Weinfeld, R Lundin, and O. Lundvall (1968) Significance for the diagnosis of iron overload of histochemical and chemical iron in the livers of control subjects. J. Clin. Pathol. 21, 35–40.PubMedCrossRefGoogle Scholar
  156. 156.
    C. Q. Edwards, M. Carroll, P. Bray, and G.E. Cartwright (1977) Hereditary haemochromatosis. Diagnosis in siblings and children. N. Engl. J. Med. 297, 7–13.PubMedCrossRefGoogle Scholar
  157. 157.
    P. Scheuer, R. Williams, and A. R. Muir (1962) Hepatic pathology in relatives of patients with idiopathic haemochromatosis. J. Pathol. Bacteriol. 84, 53–64.PubMedCrossRefGoogle Scholar
  158. 158.
    O. Lundvall and A. Weinfeld (1969) Iron stores in alcohol abusers. II. As measured with the desferrioxamine test. Acta Med Scand. 185, 271–277.PubMedCrossRefGoogle Scholar
  159. 159.
    V. Hoenig, M. Brodanova, and C. Kordac (1968) Effect of ethanol on iron tolerance and endogenous serum iron in liver cirrhosis. Scan d. J. Gastroenterol. 3, 334–338.Google Scholar
  160. 160.
    R. Williams, H. S. Williams, P. J. Scheuer, C. S. Pitcher, E. Loiseau, and S. Sherlock (1967) Iron absorption and siderosis in chronic liver disease. Q. J. Med. 36,151–166.Google Scholar
  161. 161.
    R. C. Dobemeck, D. B. Nunn, D. G. Johnson, and B. K. Chun (1963) Iron metabolism after portacaval shunt in dogs. Arch. Surg. 87, 751–756.Google Scholar
  162. 162.
    S. P. Balcerzak, W. W. Peternel, and E. W. Heinle (1967) Iron absorption in chronic pancreatitis. Gastroenterology 53, 257–264.Google Scholar
  163. 163.
    J. Murray and N. Stein (1967) Effect of ligation of the pancreatic duct on the absorption of radio iron by rats. Gastroenterology 53, 38–41.PubMedGoogle Scholar
  164. 164.
    E. Klein and W. Schmitt (1956) Eisenresorption und serum-transferrin bei leberkrankheiten. Klin. Wschr. 34, 297–300.CrossRefGoogle Scholar
  165. 165.
    L. W. Powell and B. T. Emmerson (1966) Haemosiderosis associated with xanthine oxidase inhibition. Lancet i, 239–240.Google Scholar
  166. 166.
    V. Hoenig, A. M. Brodanova, J. Strejceck, and V. Kordac (1967) Allopurinol and iron metabolism. Lancet i, 387.Google Scholar
  167. 167.
    G. A. Mendel (1963) Studies on iron absorption. I. The relationship between the rat of erythropoiesis, hypoxia and iron absorption. Blood 18, 727–736.Google Scholar
  168. 168.
    L. R. Weintraub, W. H. Conrad, and W. Crosby (1965) Regulation of the intestinal absorption of iron by the rate or erythropoiesis. Br. J. Haematol.11, 432–438.PubMedCrossRefGoogle Scholar
  169. 169.
    C. S. Pitcher and R. Williams (1963) Reduced red cell survival in jaundice and its relation to abnormal glutathione metabolism. Clin. Sci. 24, 239–252.Google Scholar
  170. 170.
    P G. Frick and J. F. Schmid (1965) Das hamolytische syndrom bei der akuten und chronischen hepatitis. Kiln. Wschr. 43, 305–309.CrossRefGoogle Scholar
  171. 171.
    L. W. Powell (1967) The effect of cirrhosis and ethanol ingestion on hepatic iron deposition in the rat. J. PathoL Bacteriol. 93,157–166.PubMedCrossRefGoogle Scholar
  172. 172.
    R. W. Chapman, M. Y. Morgan, A. M. Boss, and S. Sherlock (1983) Acute and chronic effects of alcohol on iron absorption. Dig. Dis. Sci. 28, 321–327.Google Scholar
  173. 173.
    R. M. Nunes, O. Beloqui, B. J. Potter, and P. D. Berk (1984) Iron uptake from transferrin by isolated hepatocytes: Effect of ethanol. Biochem. Biophys. Res. Commun. 125, 824–830.Google Scholar
  174. 174.
    M. E. Rubini, C. R. Kleeman, and E. Lamdin (1955) Studies on alcohol diuresis. I. The effect of ethyl alcohol ingestion on water, electrolyte and acid-base metabolism. J. Clin. Invest. 34,439–455.Google Scholar
  175. 175.
    P. B. Oliva (1970) Lactic acidosis. Am. J. Med. 48, 209–255PubMedCrossRefGoogle Scholar
  176. 176.
    F. Lundquist, N. Tygstrup, K. Winkler, K. Mellengaard, and S. Munk-Peterson (1962) Ethanol metabolism and production of free acetate in the human liver. J. Clin. Invest. 41, 955–96i.PubMedCrossRefGoogle Scholar
  177. 177.
    H. M. Redetski, T. A. Koener, J. R. Hughes, and A. G. Smith (1972) Osmometry in the evaluation of alcohol intoxication. Clin. Toxicol. 5, 343–363.Google Scholar
  178. 178.
    J. D. Beard and D. H. Knott (1968) Fluid and electrolyte balance during acute withdrawal in chronic alcoholic patients. J. Am. Med. Assoc. 204,133–139.CrossRefGoogle Scholar
  179. 179.
    S. M. Wolfe and M. Victor (1976) The relationship of hypomagnesemia and alkylosis to alcohol withdrawal symptoms. Ann. NYAcad Sci. 162, 973–984.CrossRefGoogle Scholar
  180. 180.
    B. J. Potter and T. A. McHugh (1988) Iron uptake from transferrin (TO and asialotransferrin (ATf) by hepatocytes from alcohol-fed rats. Alcohol. Clin. Exp. Res. 12, 320 (Abstract).Google Scholar
  181. 181.
    C. A. Casey, S. L. Kragskow, M. F. Sorrell, and D. J. Tuma (1990) Effect of chronic ethanol administration on total asialoglycoprotein receptor content and intracellular processing of asialoorosomucoid in isolated rat hepatocytes. Biochim. Biophys. Acta 1052,1–8.Google Scholar
  182. 182.
    B. J. Potter and T. A. McHugh (1989) Effects of iron loading on inn uptake from transferrin by hepatocytes from alcohol-fed rats. Gastroenterology 96, A646 (Abstract).Google Scholar
  183. 183.
    R. W. Chapman, M. Y. Morgan, R. Bell, and S. Sherlock (1983) Hepatic iron uptake in alcoholic liver disease. Gastroenterology 84,143–147.PubMedGoogle Scholar
  184. 184.
    L. Heilmeyer (1967) Pathogenesis of hemochromatosis. Medicine (Baltimore) 46,209–215.CrossRefGoogle Scholar
  185. 185.
    M. Pollycove, R. A. Fawwaz, and H. S. Winchell (1971) Transient hepatic deposition of iron in primary haemochromatosis with iron deficiency following venesection. J. Nucl. Med. 12,28–30.PubMedGoogle Scholar
  186. 186.
    R. G. Batey, J. E. Pettit, A. W. Nicholas, S. Sherlock, and A. V. Hoffbrand (1978) Hepatic iron clearance from serum in treated hemochromatosis. Gastroenterology 75,856–859.PubMedGoogle Scholar
  187. 187.
    M. Lombard, A. Bomford, M. Hynes, N. V. Naoumov, S. Roberts, J. Crowe, and R. Williams (1989) Regulation of the hepatic transferrin receptor in hereditary hemochromatosis. Hepatology 9,1–5.PubMedCrossRefGoogle Scholar
  188. 188.
    A. G. Morton and A. S. Tavill (1978) The control of hepatic iron uptake: Correlation with transferrin synthesis. Br. J. Haematol. 39,497–507.PubMedCrossRefGoogle Scholar
  189. 189.
    M. S. Wheby and G. Umpiere (1964) Effect of transferrin saturation on iron absorption in man. N. Engl. J. Med. 271,1391–1395.PubMedCrossRefGoogle Scholar
  190. 190.
    L. W. Sullivan and V. Herbert (1964) Suppression of hematopoiesis by ethanol. J. Clin. Invest. 43,2048–2062.PubMedCrossRefGoogle Scholar
  191. 191.
    J. Lindenbaum and C. S. Lieber (1969) Hematologic effects of alcohol in man in the absence of nutritional deficiency. N. Engl. J. Med. 281,333–338.PubMedCrossRefGoogle Scholar
  192. 192.
    L. S. Valberg, C. N. Ghent, D. A. Lloyd, J. V. Frei, and M. J. Chamberlain (1978) Diagnostic efficiency of tests for the detection of iron overload in chronic liver disease. Can. Med. Assoc. J. 119,229–236.PubMedGoogle Scholar
  193. 193.
    R. J. Dem, A. Monti, and M. F. Glynn (1963) Studies with doubly labelled iron, IV. Evidence for a second iron binding system in plasma. J. Lab. Clin. Med. 61, 2Q-291.Google Scholar
  194. 194.
    E Hosain and C. A. Finch (1964) Ferrokinetics: A study of transport iron in plasma. J. Lab. Clin. Med. 64,905–914.PubMedGoogle Scholar
  195. 195.
    B. Sarkar (1970) State of iron (III) in normal human serum: Low molecular weight of protein ligands besides transferrin. Can. J. Biochem. 48,1339–1350.Google Scholar
  196. 196.
    R. G. Batey, S. Shamir, and J. Wilms (1981) Properties and hepatic metabolism of non-transferrin-bound iron. Dig. Dis. Sci. 26, 1084–1088.Google Scholar
  197. 197.
    P. Brissot, T. L. Wright, W-L. Ma, and R. A. Weisiger (1985) Efficient clearance of non-transferrin-bound iron by rat liver. Implications for hepatic iron loading in iron overload states. J. Clin. Invest. 76,1463–1470.PubMedCrossRefGoogle Scholar
  198. 198.
    T. L. Wright, P. Brissot, W.-L. Ma, and R. A. Weisiger (1986) Characterization of non-transferrin-bound iron clearance by rat liver. J. BioL Chem. 261,10909–10914.PubMedGoogle Scholar
  199. 199.
    R. G. Batey, P. Lai Chun Fong, S. Shamir, and S. Sherlock (1980) A nontransferrin-bound serum iron in idiopathic hemochromatossis. Dig. Dis. Sci. 25, 340–346.Google Scholar
  200. 200.
    R. A. Fawwaz, H. S. Winchell, M. Pollycove, and T. Sargent (1967) Hepatic iron deposition in humans. Blood 30,417–421.PubMedGoogle Scholar
  201. 201.
    M. J. Giglio, R. C. Santoro, and E. Bozzini (1984) Effect of chronic ethanol administration on production and response to erythropoietin in the mouse. Alcohol. Clin. Exp. Res. 8, 323–325.Google Scholar
  202. 202.
    L. W. Sullivan and V. Herbert (1964) Suppression of hematopoiesis by ethanol. J. Clin. Invest. 43,2048–2062.PubMedCrossRefGoogle Scholar
  203. 203.
    J. D. Hines (1969) Reversible megaloblastic and sideroblastic marrow abnormalities in alcoholic patients. Br. J. Haematol. 16, 87–101.PubMedCrossRefGoogle Scholar
  204. 204.
    H. Kondo, K. Saito, P. Grasso, and P. Aisen (1988) Iron metabolism in the erythrophagocytosing Kupffer cell. Hepatology 8,32–38.PubMedCrossRefGoogle Scholar
  205. 205.
    J.-C. Sibille, H. Kondo, and R Aisen (1988) Interactions between isolated hepatocytes and Kupffer cells in iron metabolism: A possible role for ferritin as an iron carrier protein. Hepatology 8,296–301.PubMedCrossRefGoogle Scholar
  206. 206.
    U. Mack, L. W. Powell, and J. W Halliday (1983) Detection and isolation of a hepatic membrane receptor for ferritin. J. Biol. Chem. 248, 4672–4675.Google Scholar
  207. 207.
    P. C. Adams, L. W. Powell, and J. W. Halliday (1988) Isolation of a human hepatic ferritin receptor. Hepatology 9, 719–721CrossRefGoogle Scholar
  208. 208.
    P. C. Adams, U. Mack, L. W. Powell, and J. W. Halliday (1988) Isolation of a porcine hepatic ferritin receptor. Comp. Biochem. PhysioL (B) 90, 837–841.Google Scholar
  209. 209.
    P. C. Adams and L. A. Chau (1990) Hepatic ferritin uptake and hepatic iron. Hepatology 1, 805–808.CrossRefGoogle Scholar
  210. 210.
    p Pootrakul, B. Josephson, H. A. Huebers, and C. A. Fmch (1988) Quantitation of ferritin iron in plasma, an explanation for non-transferrin iron. Blood 71,11201123.Google Scholar
  211. 211.
    M. W Hentze, S. W. Caughman, T. A. Rouault, J. G. Barriocanal, A. Dancis, J. B. Harford, and R. D. Klausner (1987) Identification of the iron-responsive element for the translational regulation of human ferritin mRNA. Science 238, 1570–1573.PubMedCrossRefGoogle Scholar
  212. 212.
    J.-J. Lin, M. M. Daniels-McQueen Patino, L. Gaffield, W. E. Walden, and R. E. Thach (1990) Derepression of ferritin messenger RNA translation by hemin in vitro. Science 247, 74–77.PubMedCrossRefGoogle Scholar
  213. 213.
    G. D. Nadkarni and U. R. Deshpande (1982) Liver ferritin synthesis following chronic alcohol administration to rats: Modulation by propythiouracil. Experientia 38, 372–373.PubMedCrossRefGoogle Scholar
  214. 214.
    R. Moirand, G. Lescoat, N. Hubert, J. F. Dezier, and N. Pasdeloup (1989) Ethanol induction of ferritin in a human hepatoblastoma cell line (HepG2). Hepatology 10, 573 (Abstract).Google Scholar
  215. 215.
    H. P. Roeser, D. J. Sizemore, A. Nikles, and B. E. Cham (1983) Tissue ferritin in scorbutic guinea pigs. Br. J. Haematol. 55, 325–333.PubMedCrossRefGoogle Scholar
  216. 216.
    H. P. Roeser, J. W. Halliday, D. J. Sizemore, A. Nikles, and D. Willgos (1980) Serum ferritin in ascorbic acid deficiency. Br. J. Haematol. 45, 459–466.PubMedCrossRefGoogle Scholar
  217. 217.
    B. E. Cham, H. P. Roeser, and A. C. Nickles (1990) Ascorbic acid deficiency affects the metabolism of cytosolic ferritin but not lipid-associated ferritin in livers of guinea pigs. Biochem. J. 267, 535–537.PubMedGoogle Scholar
  218. 218.
    S. M. Sabesin and L. B. Thomas (1964) Parenchymal siderosis in patients with pre-existing portal cirrhosis. A pathologic entity simulating idiopathic and transfusional hemochromatosis. Gastroenterology 46,447–485.Google Scholar
  219. 219.
    L. W. Powell and J. F. R. Kerr (1975) The pathology of the liver in hemochromatosis, in Pathobiology Annual, H. Joacim, ed Academic, New York, pp. 317–337.Google Scholar
  220. 220.
    M. L. Bassett, J. W. Halliday, and L. W. Powell (1981) HLA typing in idiopathic haemochromatosis: Distinction between homozygotes and heterozygotes with biochemical expression. Hepatology 1,120–126.PubMedCrossRefGoogle Scholar
  221. 221.
    M. L. Bassett, J. W. Halliday, R. A. Ferris, and L. W. Powell (1904) Hemochromatosis: Predictive accuracy of biochemical screening tests. Gastroenterology 87, 628–633.Google Scholar
  222. 222.
    D. J. Pounder (1984) Problems in the necropsy diagnosis of alcoholic liver disease. Am. J. Forensic Mect. Pathol. 5,103–108.CrossRefGoogle Scholar
  223. 223.
    G. H. Addison, M. R. Beamish, C. N. Hales, M. Hodgkin, A. Jacobs, and P. Llewellin (1972) An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. J. Clin. Pathol. 25, 326–329.PubMedCrossRefGoogle Scholar
  224. 224.
    G. O. Walters, E M. Miller, and M. Worwood (1973) Serum ferritin concnetration and iron stores in normal subjects. J. Clin. Pathol. 26, 770–772.PubMedCrossRefGoogle Scholar
  225. 225.
    D. A. Lipschitz, J. D. Cook, and C. A. Finch (1974) A clinical evaluation of serum ferritin. N. Engl. J. Med. 290,1213–1216.PubMedCrossRefGoogle Scholar
  226. 226.
    W. R. Bezwoda, T. H. Bothwell, J. D. Torrance, A. P. MacPhail, R. W. Charlton, G. Kay, and J. Levin (1979) The relationship between marrow iron stores, plasma ferritin concentrations and iron absorption. Scand. J. Haematol. 22, 113–120.Google Scholar
  227. 227.
    T. H. Bothwell, R. W. Charlton, J. D. Cook, and C. A. Finch (1979) Iron metabolism in man. Blackwell, Oxford, pp. 90–103.Google Scholar
  228. 228.
    M. Worwood (1979) Serum ferritin. CRC Crit. Rev. Clin. Lab. Sci. 10, 171–204.CrossRefGoogle Scholar
  229. 229.
    S. Nakano, T. Kumada, K. Sugiyama, H. Watahili, and I. Takeda (1984) Clinical significance of serum ferritin for hepatocellular carcinoma. Am. J. Gastroenterol. 79,623–627.PubMedGoogle Scholar
  230. 230.
    C. W. Aungst (1968) Ferritin in body fluids. J. Lab. Clin. Med. 71,517–522.PubMedGoogle Scholar
  231. 231.
    J. Prieto, M. Barry, and S. Sherlock (1975) Serum ferritin in patients with iron overload and with acute and chronic liver diseases. Gastroenterology 68, 525–533.PubMedGoogle Scholar
  232. 232.
    S. Hussein, M. Laulicht, and A. V. Hoffbrand (1978) Serum ferritin in megaloblastic anaemia. Scand. J. Haematol. 20, 241–245.Google Scholar
  233. 233.
    L. W. Powell, J. W. Halliday, and L. V. McKeering (1975) Studies of serum ferritin with emphasis on its importance in clinical medicine, in Proteins of Iron Storage and Transport in Biochemistry and Medicine, R. R. Crichton, ed. North Holland, Amsterdam, pp. 215–221.Google Scholar
  234. 234.
    H. Kristenson, G. Fex, and E. Trell (1981) Serum ferritin, gammaglutamyltransferase and alcohol consumption in healthy middle-aged men. Drug Alcohol Depend. 8, 43–50.PubMedCrossRefGoogle Scholar
  235. 235.
    L. Lundin, R. Hallgren, G. Birgegard, and L. Wide (1981) Serum ferritin in alcoholics and relation to liver damage, iron state and erythropoietic activity. Acta Med. Scand. 209, 327–331.Google Scholar
  236. 236.
    T. E. Meyer, C. Kassianides, T. H. Bothwell, and A. Green (1984) Effects of heavy alcohol consumption on serum ferritin concentrations. S. Afr. Med J. 6, 573–575.Google Scholar
  237. 237.
    L. W. Powell and H. M. Lloyd (1975) Haemochromatosis. Arch. Int. Med 135, 1269.Google Scholar
  238. 238.
    T. C. Iancu, H. B. Neustein, and B. H. Landing (1977) The liver in thalassaemia major: Ultrastructural observations, in Iron Metabolism, Ciba Foundation Symposium #51, Elsevier, Amsterdam, pp. 293–316.Google Scholar
  239. 239.
    M. L. Bassett, J. W. Halliday, and L. W. Powell (1986) Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 6, 24–29.PubMedCrossRefGoogle Scholar
  240. 240.
    L. R. Weintraub, A. Goral, J. Grasso, C. Franzblau, A. Sullivan, and S. Sullivan (1985) Pathogenesis of hepatic fibrosis in experimental iron overload. Br. J. Haematol. 59, 321–331.PubMedCrossRefGoogle Scholar
  241. 241.
    B. E Trump, J. M. Valigorsky, A. A. Arstila, W. J. Mergner, and T. D. Kinney (1973) The relationship of intracellular pathways of iron metabolism to cellular iron overload and iron storage diseases. Am. J. Pathol. 72, 295–324.PubMedGoogle Scholar
  242. 242.
    H. L. Bonkowsky, J. F. Healy, P. R. Sinclair, J. F. Sinclair, and J. S. Pomeroy (1981) Iron and the liver: Acute and long-term effects of iron loading on hepatic haem metabolism. Biochem. J. 196, 57–64.PubMedGoogle Scholar
  243. 243.
    B. R. Bacon, A. S. Tavill, G. M. Brittenham, C. H. Park, and R. O. Recknagel (1983) Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J. Clin. Invest. 71, 429–439.PubMedCrossRefGoogle Scholar
  244. 244.
    N. R. DiLuzio (1966) A mechanism of acute ethanol-induced fatty liver and the modification of liver injury by antioxidants. Lab. Invest. 15, 50–63.Google Scholar
  245. 245.
    R. C. Reitz (1975) A possible mechanism for the peroxidation of lipids due to chronic ethanol consumption. Biochim. Biophys. Acta 380,145–154.Google Scholar
  246. 246.
    A. Boveris, C. G. Fragga, A. I. Varsaysky, and O. R. Koch (1983) Increased chemiluminescence and superoxide production in the livers of chronically ethanol-treated rats. Arch. Biochem. Biophys. 227,534–541.Google Scholar
  247. 247.
    G. Krikun and A. I. Cederbaum (1986) Effect of chronic ethanol consumption on microsomal lipid peroxidation: Role of iron and comparison between controls. FEBS Lett. 208, 292–296.PubMedCrossRefGoogle Scholar
  248. 248.
    U. Koster, D. Albrecht, and H. Kappus (1977) Evidence for carbon tetrachloride and ethanol-induced lipid peroxidation in vivo demonstrated by ethane production in mice and rats. Toxicol. Appl. Pharmacol. 41, 639–648.Google Scholar
  249. 249.
    R. E. Litov, D. H. Irving, J. E. Downey, and A. L. Tappel (1978) Lipid peroxidation: A mechanism involved in acute ethanol toxicity as demonstrated by in vivo pentane production in the rat. Lipids 13, 305–307.PubMedCrossRefGoogle Scholar
  250. 250.
    C. S. Lieber (1980) Alcohol, protein metabolism and liver injury. Gastroenterology 79, 373–390.PubMedGoogle Scholar
  251. 251.
    S. Shaw, E. Jayatilleke, and C. S. Lieber (1988) Lipid peroxidation as a mechanism of alcoholic liver injury: Role of iron mobilization and microsomal induction. Alcohol 5,135–140.PubMedCrossRefGoogle Scholar
  252. 252.
    A. I. Cederbaum (1989) Oxygen radical generation by microsomes: Role of iron and implications for alcohol metabolism and toxicity. Free Rad. Biol. Med. 7, 559–567.Google Scholar
  253. 253.
    V D. Antonenkov, S. V. Pirozhkov, S. V. Popova, and L. F. Pachenko (1989) Effect of chronic ethanol treatment on lipid peroxidation in rat liver homogenate and subcellular fractions. Int. J. Biochem. 21,1191–1195.PubMedCrossRefGoogle Scholar
  254. 254.
    M. G. Irving, J. W. Halliday, and L. W. Powell (1988) Association between alcoholism and increased hepatic iron stores. Alcohol. Clin. Exp. Res. 12, 7–13.Google Scholar
  255. 255.
    R. A. Cooper (1980) Hemolytic syndromes and red cell membrane abnormalities in liver disease. Semin. Hematol.17,103–112.Google Scholar
  256. 256.
    J. Sanchez, M. Casas, and R. Rama (1988) Effect of chronic ethanol administration on iron metabolism in the rat. Eur. J. Haematol. 41, 321–325.PubMedCrossRefGoogle Scholar
  257. 257.
    M. C. Linder, J. R. Moor, L. E. Scott, and H. N. Munro (1973) Mechanism of sex difference in rat tissue iron stores. Biochim. Biophys. Acta 297, 70–80.Google Scholar
  258. 258.
    A. D. Heys and T. L. Dormandy (1981) Lipid peroxidation in iron-overloaded spleens. Clin. Sci. 60, 295–301.Google Scholar
  259. 259.
    D. Savage and J. Lindenbaum (1986) Anemia in alcoholics. Medicine 65, 322–338.PubMedCrossRefGoogle Scholar
  260. 260.
    A. Kristensson-Aas, S. Wallerstedt, C. Alling, G. Cederblad, and B. Magnusson (1986) Haematological findings in chronic alcoholics after heavy drinking with special reference to haemolysis. Eur. J. Clin. Invest. 16, 178–183.PubMedCrossRefGoogle Scholar
  261. 261.
    M. R. Clemens, H. Einsele, H. Remmer, and H. D. Waller (1985) Decreased susceptibility of red blood cells to lipid peroxidation in patients with alcoholic liver cirrhosis. Clin. Chim. Acta 145, 283–288.Google Scholar
  262. 262.
    F. Michot and J. Gut (1987) Alcohol-induced bone marrow damage: A bone marrow study in alcohol-dependent individuals. Acta Haematol. 78, 252–257.PubMedCrossRefGoogle Scholar
  263. 263.
    M. Kumazawa, M. Misaki, M. Baba, T. Shima, and S. Suzuki (1986) Transferrin receptor on rat Kupffer cells in primary culture. Liver 6,138–144.PubMedCrossRefGoogle Scholar
  264. 264.
    R. Andreesen, J. Osterholz, H. Bodemann, K. J. Bross, U. Costabel, and G. W. Lohr (1984) Expression of transferrin receptors and intracellular ferritin during terminal differentiation of human monocytes. Blut 49,195–202.PubMedCrossRefGoogle Scholar
  265. 265.
    T. Nishisato and P. Aisen (1982) Uptake of transferrin by rat peritoneal macrophages. Br. J. Haematol. 52,631–640.PubMedCrossRefGoogle Scholar
  266. 266.
    D. J. Sizemore and M. L. Bassett (1984) Monocyte transferrin-iron uptake in hereditary hemochromatosis. Am. J. Hematol. 16, 347–354.PubMedCrossRefGoogle Scholar
  267. 267.
    L T. Yam, H. E. Finkel, L. R. Weintraub, and W. H. Crosby (1968) Circulating iron-containing macrophages in hemochromatosis. N. Engl. J. Med. 275, 512–514.CrossRefGoogle Scholar
  268. 268.
    M. L. Bassett, J. W. Halliday, and L. W. Powell (1982) Ferritin synthesis in peripheral blood monocytes in idiopathic hemochromatosis. J. Lab. Clin. Med. 100,137–145.PubMedGoogle Scholar
  269. 269.
    G. Fillet and G. Marsaglia (1975) Idiopathic hemochromatosis: Abnormality in RBC transport of iron by the reticuloendothelial system. Blood 46, 1007.Google Scholar
  270. 270.
    E. Baraona, M. T. Leo, S. A. Borowsky, and C. S. Lieber (1975) Alcoholic hepatomegaly: Accumulation of protein in the liver. Science 190, 794–795.PubMedCrossRefGoogle Scholar
  271. 271.
    M. A. Rothschild, M. Oratz, J. Morland, S. S. Schreiber, A. Burks, and B. Martin (1980) Effects of ethanol on protein synthesis and secretion. Pharmacol. Biochem. Behan 13 (Suppl. 1), 31–36.Google Scholar
  272. 272.
    G. D. Volentine, D. J. Tama, and M. F. Sorrell (1984) Acute effects of ethanol on hepatic glycoprotein secretion in the rat. Gastroenterology 86, 225–229.PubMedGoogle Scholar
  273. 273.
    M. F. Sorrell, J. M. Nauss, T. M. Donahue, Jr, and D. J. Tuma (1983) Effect of chronic ethanol administration on hepatic glycoprotein secretion in the rat. Gastroenterology 84, 580–586.PubMedGoogle Scholar
  274. 274.
    B. Wallin, J. Morland, and A.-M. Fikke (1981) Combined effects of ethanol and pH-change on protein synthesis in isolated rat hepatocytes. Acta Pharmacol. Toxicol. 49,134–140.Google Scholar
  275. 275.
    K. N. Jeejeebhoy, M. J. Phillips, A. Bruce-Robertson, J. Ho, and U. Sodtke (1972) The acute effects of ethanol on albumin, fibrinogen and transferrin synthesis in the rat. Biochem. J. 126, 1111–1126.PubMedGoogle Scholar
  276. 276.
    M. E. Gardiner and E. H. Morgan (1981) Effect of reduced atmospheric pressure and fasting on transferrin synthesis in the rat. Life Sci. 29,1641–1648.PubMedCrossRefGoogle Scholar
  277. 277.
    A. Smith-Keilland and J. Morland (1981) Reduced hepatic protein synthesis after long term ethanol treatment in fasted rats. Dependence on animal handling before measurement. Biochem. Pharmacol. 30, 2377–2379.Google Scholar
  278. 278.
    A. G. Morton and A. S. Tavill (1977) The role of iron in the regulation of hepatic transferrin synthesis. Br. J. Haematol. 36, 383–394.PubMedCrossRefGoogle Scholar
  279. 279.
    A. G. Morton and A. S. Tavill (1978) The control of hepatic iron uptake: Correlation with transferrin synthesis. Br. J. Haematol. 39, 4497–507.CrossRefGoogle Scholar
  280. 280.
    M. J. O’Shea, D. Kershnobich, and A. S. Tavill (1973) Effects of inflammation on iron and transferrin metabolism. Br. J. Haematol. 25, 707–714.PubMedCrossRefGoogle Scholar
  281. 281.
    B. J. Potter, R. W. G. Chapman, R. M. Nunes, D. Sorrentino, and S. Sherlock (1985) Transferrin metabolism in alcoholic liver disease. Hepatology 5, 714–721.PubMedCrossRefGoogle Scholar
  282. 282.
    S. Jamum and N. A. Lassen (1961) Albumin and transferrin metabolism in infectious and toxic diseases. Scand. J. Clin. Lab. invest. 40, 2143–2152.Google Scholar
  283. 283.
    R. Hoffenberg, A. H. Gordon, E. G. Blake, and L. N. Louis (1970) Plasma protein catabolism in the rat. The effect of alterations of albumin concentration and dietary protein depletion. Biochem. J. 118, 401–404.Google Scholar
  284. 284.
    J. P. Milsom and R. G. Batey (1979) The mechanism of hepatic iron uptake from native and denatured transferrin and its subcellular metabolism in the liver cell. Biochem. J. 182,117–125.PubMedGoogle Scholar
  285. 285.
    E. Regoeczi, R A. Chindemi, M. W. C. Hatton, and L. R. Berry (1980) Galactose-specific elimination of human asialotransferrin by the bone marrow in the rabbit. Arch. Biochem. Biophys. 205, 76–84.Google Scholar
  286. 286.
    G. Ashwell and A. G. Morell (1974) The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins, in Advances in Enzymology, vol 41. A. Meister, ed. Wiley, New York, pp. 99–128.Google Scholar
  287. 287.
    E. Regoeczi, P. A. Chindemi, and M. T. Debanne (1984) Transferrin glycans: A possible link between alcoholism and hepatic siderosis. Alcohol. Clin. Exp. Res. 8, 287–292.Google Scholar
  288. 288.
    S. P. Young, A. Bomford, and R. Williams (1983) Dual pathways for the uptake of rat asialotransferrin by rat hepatocytes. J. Biol. Chem. 258, 4972–4976.PubMedGoogle Scholar
  289. 289.
    H. Stibler, C. Allgulander, S. Borg, and K. G. Kjellin (1978) Abnormal microheterogeneity of transferrin in serum and cerebrospinal fluid in alcoholism. Acta Med Scand 204, 49–56.PubMedCrossRefGoogle Scholar
  290. 290.
    H. Stibler, S. Borg, and C. Allgulander (1979) Clinical significance of abnormal heterogeneity of transferrin in relation to alcohol consumption. Acta Med. Scand. 206, 275–281.Google Scholar
  291. 291.
    O. Vesterberg, S. Petren, and D. Schmidt (1984) Increased concentrations of a transferrin variant after alcohol abuse. Clin. Chim. Acta 141,33–39.Google Scholar
  292. 292.
    E. L. Storey, U. Mack, L. W. Powell, and J. W. Halliday (1985) Use of chromatofocusing to detect a transferrin variant in serum of alcoholic subjects. Clin. Chem. 31,1543–1545.Google Scholar
  293. 293.
    H. Stibler, O. Sydow, and S. Borg (1980) Quantitative estimation of abnormal microheterogeneity of serum transferrin in alcoholics. Pharmacol. Biochem. Behan 13 (Suppl. 1), 47–51.Google Scholar
  294. 294.
    H. Stibler and S. Borg (1981) Evidence of a reduced sialic acid content in serum transferrin in male alcoholics. Alcohol. Clin. Exp. Res. 5,545–549.Google Scholar
  295. 295.
    C. J. Dekker, M. J. Kroos, C. Van der Heul, and H. G. Van Eijk (1984) Iron uptake from sialotransferrins by rat reticulocytes. Int J. Biochem. 16, 787–792.PubMedCrossRefGoogle Scholar
  296. 296.
    H. Stibler and S. Borg (1986) Carbohydrate composition of serum transferrin in alcoholic patients. Alcohol. Clin. Exp. Res. 10, 61–64.Google Scholar
  297. 297.
    H. Stibler, S. Borg, and M. Joustra (1986) Micro anion exchange chromatography or carbohydrate-deficient transferrin in relation to alcohol consumption (Swedish patent 8400587–5). Alcohol. Clin. Exp. Res. 10,535–544.Google Scholar
  298. 298.
    U. J. Behrens, T. M. Worner, L. F. Braly, E Schaffner, and C. S. Lieber (1988) Carbohydrate-deficient transferrin, a marker for chronic alcohol consumption in different ethnic populations. AlcohoL Clin. Exp. Res. 12,427–432.Google Scholar
  299. 299.
    U. Behrens, T. M. Womer, and C. S. Lieber (1988) Changes in carbohydrate-deficient transferrin levels after alcohol withdrawal. Alcohol. Clin. Exp. Res. 12, 539–544.Google Scholar
  300. 300.
    M. F. Sorrell and D. J. Tuma (1978) Selective impairment of glycoprotein metabolism by ethanol and acetaldehyde in rat liver slices. Gastroenterology 75, 200–208.PubMedGoogle Scholar
  301. 301.
    E. Regoeczi, P. A. Chindemi, M. T. Debanne, and P. A. Charlwood (1982) Partial resialylation of human asialotransferrin type 3 in the rat. Proc. NatL Acad. Sci. USA 79, 2226–2230.PubMedCrossRefGoogle Scholar
  302. 302.
    E. Regoeczi, P. A. Charlwood, and P. A. Chindemi (1985) The effects of cytotropic compounds on the resialylation of human asialotransferrin type 3 in the rat. Exp. Cell. Res. 157,495–503.Google Scholar
  303. 303.
    M. T. Debanne and E. Regoeczi (1981) Subcelhilar distribution of human asialotransferrin type 3 in the rat liver. J. BioL Chem. 256,11266–11272.PubMedGoogle Scholar
  304. 304.
    L. Marzella and H. Glaumann (1980) Increased degradation in rat liver induced by vinblastine: I. Biochemical characterization. Lab. Invest. 42, 8–17.Google Scholar
  305. 305.
    M. D. Snider and O. C. Rogers (1985) Intracellular movement of cell surface receptors after endocytosis: Resialylation of asialo-transferrin receptor in human erythroleukemia cells. J. Cell BioL 100, 826–834.PubMedCrossRefGoogle Scholar
  306. 306.
    J. J. M. Bergeron, J. H. Ehrenreich, P. Siekevitz, and G. E. Palade (1973) Golgi fractions prepared from rat liver homogenates. I. Isolation procedure and morphological characterization. J. Cell Biol. 59, 45–72.Google Scholar
  307. 307.
    H. Stibler, E. Burns, T. Kruckeberg. P. Gaetano, E. Cerven, S. Borg, and B. Tabakoff (1983) Effect of ethanol on synaptosomal sialic acid metabolism in the developing rat brain. J. Neurosci. 59, 21–35.Google Scholar
  308. 308.
    S. Petren and O. Vesterberg (1988) Concentration differences in isoforms of transferrin in blood from alcoholics during abuse and abstinence. Clin. Chim. Acta. 175,183–188.Google Scholar
  309. 309.
    C. J. Dekker, M. J. Kroos, C. Van der Heul, and H. G. Van Eijk (1985) Uptake of sialo and asialo transferrins by isolated rat hepatocytes. Comparison of a heterologous and a homologous sytem. Int. J. Biochem. 17, 701–706.PubMedCrossRefGoogle Scholar
  310. 310.
    S. P. Young, A. Bomford, and R. Williams (1983) Dual pathways for the uptake of rat asialotransferrin by rat hepatocytes. J. Biol. Chem. 258,4972–4976.PubMedGoogle Scholar
  311. 311.
    E. Regoeczi and A. Koj (1985) Diacytosis of human asialotransferrin type 3 in the rat liver is due to the sequential engagement of two receptors. Exp. Cell. Res. 160,1–8.Google Scholar
  312. 312.
    S. P. Wilkinson, J. Canalese, and R. Williams (1980) Consequences of kupffer cell failure in fulminant hepatic failure and cirrhosis with particular reference to endotoxaemia, in The Reticuloendothelial System and the Pathogenesis of Liver Disease. H. Liehr and M. Grun, eds. Elsevier/North Holland Biomedical Press, Amsterdam, pp. 337–340.Google Scholar
  313. 313.
    H. Prytz, M. Bjomeboe, F. Orskov, and M. Hilden (1973) Antibodies to Escherichia coli in alcoholic and non-alcoholic patients with cirrhosis of the liver. Scand. J. Gastroenterol. 8, 433–438.Google Scholar
  314. 314.
    A. Simjee, J. Hamilton-Miller, H. Thomas, W. Brumfitt, and S. Sherlock (1975) Antibodies to Escherichia coli in chronic liver diseases. Gut 16, 871–875.PubMedCrossRefGoogle Scholar
  315. 315.
    P Staun-Olsen, M. Bjomeboe, H. Prytz, A. C. Thomsen, and F. Orskov (1983) Escherichia coli antibodies in alcoholic liver disease. Correlation to alcohol consumption, alcoholic hepatitis and serum IgA. Scand. J. Gastroenterol. 18, 889–896.Google Scholar
  316. 316.
    C. Bode, V. Kugler, and J. C. Bode (1987) Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J. Hepatol. 4, 8–14.PubMedCrossRefGoogle Scholar
  317. 317.
    B. S. Bhagwandeen, M. Apte, L. Manwarring, and J. Dickeson (1987) Endotoxin induced hepatic necrosis in rats on an alcohol diet. J. Pathol. 151,47–53.CrossRefGoogle Scholar
  318. 318.
    R. J. Elm and S. M. Wolf (1974) The role of iron in non-specific resistance to infection induced by endotoxin. J. Immunol.112, 737–745.Google Scholar
  319. 319.
    R. F. Kampschmidt and G. A. Schultz (1961) Hypoferremia in rats following injection of bacterial endotoxin. Proc. Soc. Exp. Biol. Med. 106, 870–871.PubMedGoogle Scholar
  320. 329.
    B J. Potter, B. Blades, T. A. McHugh, R. M. Nunes, O. Beloqui, P. A. Slott, and J. H. Rand (1989) Effects of endotoxin on iron uptake by the hepatocyte. Am. J. PhysioL 257, G524–G531.PubMedGoogle Scholar
  321. 321.
    B. J. Potter, T. A. McHugh, and J. H. Rand (1988) The effects of endotoxine on iron uptake by hepatocytes from chronically alcohol-fed rats. Hepatology 8, 1240 (Abstract).Google Scholar
  322. 322.
    B. Nosslin (1973) Analysis of disappearance time curves after single injection of labeled proteins, in Protein Turnover, Ciba Foundation Symposium 9 (New Series). G. E. W. Wolsteinholm and M. O’Connor, eds. Assoc. Sci. Publ., Amsterdam, pp. 113–130.Google Scholar
  323. 323.
    G. C. T. Yeoh, J. A. Wassenberg, E. Edkins, and I. T. Oliver (1979) Synthesis and secretion of albumin and transferrin by foetal rat hepatocyte cultures.Biochim. Biophys. Acta 565,347–355.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 1991

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  • Barry J. Potter

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