Immune Deficiencies in Chronic Lymphocytic Leukemia and Multiple Myeloma

  • Alan Winkelstein
  • P. Susan Jordan
Part of the Allergy and Immunology book series (ALIM, volume 2)

Abstract

The B-cell malignancies chronic lymphocytic leukemia (CLL) and multiple myeloma represent clonal neoplasms in which the cells are arrested or “ frozen” at a defined stage of cell maturation. Both disorders are characterized by increased susceptibility to infections; in part, this results from a disruption in the normal processes for synthesis of immunoglobulins. Typically, CLL patients exhibit impaired antibody production, often resulting in panhypo- gammaglobulinemia. In multiple myeloma, the malignant plasma cells elaborate a single species of immunoglobulin and/or a monoclonal light chain. By contrast, the polyclonal antibody synthesis required for protection against bacterial infection is often impaired. Thus, these patients can be considered “functionally” hypogamma- globulinemic. This review will focus on the immune deficiencies associated with these two B-cell malignancies and summarize the results of preliminary clinical trials that evaluated the efficacy of IVIGs as replacement therapy.

Keywords

Placebo Leukemia Tuberculosis Oncol Neutropenia 

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Alan Winkelstein
    • 1
  • P. Susan Jordan
    • 2
  1. 1.Montefiore University HospitalPittsburghUSA
  2. 2.PharmDPomonaUSA

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