Abstract
Gamma-globulin therapy has been practiced since the turn of the century, when clinicians used heterologous protein preparations to provide passive immunity to exposed unimmunized hosts. The need for ay-globulin preparation capable of transferring broad-based humoral immunity was recognized in the early 1950s following the description of agammaglobulinemia by Bruton. Since that time, tremendous progress has been made in the manufacturing of safe and efficacious γ-globulin products, culminating in the development of agents that can be administered intravenously. Such preparations contain a large array of antibody specificities, having been prepared from the blood of thousands of healthy donors.
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Levinson, A.I. (1992). The Use of IVIG in Neurological Disease. In: Ballow, M. (eds) IVIG Therapy Today. Allergy and Immunology, vol 2. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0417-6_10
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DOI: https://doi.org/10.1007/978-1-4612-0417-6_10
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