Comparison of Human Versus Rodent Cell Transformation: Importance of Cell Aging
Rodent models are used for the identification of carcinogenic agents and for studies of mechanisms of carcinogenesis. An underlying assumption is that the information gained from animal studies will extend to humans. However, a fundamental difference must exist between human and rodents in terms of neoplastic development because cancers generally arise in rodents after a few years whereas the same cancers require decades in humans. For example, the spontaneous incidence of tumors in rodents after two years is approximately equal to that in humans at 70 years (1). It is an important problem in cancer biology to understand this fundamental difference between rodents and humans. One approach to this problem is to elucidate the underlying mechanisms of neoplastic transformation of cells in culture from different species by determining the number and type of genetic events involved. Cellular and molecular studies offer the opportunity to examine species differences and similarities.
KeywordsHuman Chromosome Cellular Senescence Population Doubling Hybrid Clone Werner Syndrome
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