Abstract
Epstein Barr Virus (EBV) infection of primary Blymphocytes results in a persistent latent infection characterized by cell growth transformation and expression of six viral nuclear proteins, two viral integral membrane proteins and two viral small RNAs (for review see 1). EBV nuclear protein 2 (EBNA-2) is one of the first genes expressed following primary B lymphocyte infection, in vitro (2, 3, 4, 5). EBNA-2 transactivates expression of LMP1 (6 ,7); and upregulates expression of cellular genes including CD23 (8, 9), CD21 (9, 10), and cfgr (11).
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Reference
Kieff, E. and D. Liebowitz. 1990. Epstein-Barr virus and its replication, p. 1889–1920. In B. Fields and D. Knipe (ed.). Virology, Raven Press, New York.
Moss, D. J., T. B. Sculley, and J. M. Pope. 1986. J. Virol. 58:988–990.
Allday, M. J., D. H. Crawford, and B. E. Griffin. 1989. J. Gen. Virol. 70:1755–1764.
Rooney, C., G. Howe, S. H. Speck, and G. Miller. 1989. J. Virol. 63:1531–1539.
Alfieri, C., M. Birkenbach, and E. Kieff. 1990. In Press.
Abbot, S. D., M. Rowe, K. Cadwallader, A. Ricksten, J. Gordon, F. Wang, L. Rymo, and A. B. Rickinson. 1990. J. Virol. 64:2126–2134.
Wang, F., S. Tsang, M. G. Kurilla, J. I. Cohen, and E. Kieff. 1990. J. Virol. 64:3407–3416.
Wang, F., C. D. Gregory, M. Rowe, A. B. Rickinson, D. Wang, M. Birkenbach, H. Kikutani, T. Kishimoto, and E. Kieff. 1987. Proc. Natl. Acad. Sci. USA 84:3452–3456.
Wang, F., C. Gregory, C. Sample, M. Rowe, D. Liebowitz, R. Murray, A. Rickinson, and E. Kieff. 1990. J. Virol. 64:2309–2318.
Cordier, R., A. Calender, M. Billaud, U. Zimber, G. Rousselet, O. Pavlish, J. Banchereau, T. Tursz, G. Bornkamm, and G.M. Lenoir. 1990. J. Virol. 64:1002–1013.
Knutsen, J.C. 1990. J. Virol. 64:2530–2536.
Hammerschmidt, W. and B. Sugden. 1989. Nature 340:393–397.
Cohen, J. I., F. Wang, J. Mannick, and E. Kieff. 1989. Proc. Natl. Acad. Sci. USA 86:9558–9562.
Baichwal, V.R., and B. Sugden. 1988. Oncogene 2:461–467.
Wang, D., D. Liebowtiz, and E. Kieff. 1985. Cell 43:831–840.
Wang, D., D. Liebowitz, and E. Kieff. 1988. J. Virol. 62:2337–2346.
Dambaugh, T., F. Wang, K. Hennessy, E. Woodland, A. Rickinson, and E. Kieff. 1986. J. Virol. 59:453–462.
Cohen, J. I., F. Wang, and E. Kieff. 1990. In Press.
Ghosh, D., and E. Kieff. 1990. J. Virol. 64:1855–1858.
Laimins, L. A., P. Gruss, R. Pozzatti, and G. Khoury. 1984. J. Virol. 49:183–189.
Fennewald, S., V. Van Santen, and E. Kieff. 1984. J. Virol. 51:411–419.
Luckow, B. and G. Schutz. 1987. Nucl. Acids. Res. 15:5490.
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Tsang, S., Wang, F., Kieff, E. (1991). EBNA-2 Transactivation of LMP1. In: Ablashi, D.V., Huang, A.T., Pagano, J.S., Pearson, G.R., Yang, C.S., Ablashi, K.L. (eds) Epstein-Barr Virus and Human Disease · 1990. Experimental Biology and Medicine, vol 24. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0405-3_6
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DOI: https://doi.org/10.1007/978-1-4612-0405-3_6
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