EBNA-2 Transactivation of LMP1

  • S. Tsang
  • F. Wang
  • E. Kieff
Part of the Experimental Biology and Medicine book series (EBAM, volume 24)


Epstein Barr Virus (EBV) infection of primary Blymphocytes results in a persistent latent infection characterized by cell growth transformation and expression of six viral nuclear proteins, two viral integral membrane proteins and two viral small RNAs (for review see 1). EBV nuclear protein 2 (EBNA-2) is one of the first genes expressed following primary B lymphocyte infection, in vitro (2, 3, 4, 5). EBNA-2 transactivates expression of LMP1 (6 ,7); and upregulates expression of cellular genes including CD23 (8, 9), CD21 (9, 10), and cfgr (11).


Chloramphenicol Acetyl Transferase Herpes Simplex Virus Thymidine Kinase SV40 Promoter Growth Transformation Chloramphenicol Acetyl Transferase Activity 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • S. Tsang
    • 1
  • F. Wang
    • 1
  • E. Kieff
    • 1
  1. 1.Departments of Medicine and Microbiology and Molecular GeneticsHarvard medical SchoolBostonUSA

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