Abstract
EBV humoral immunology has played a major role in studies directed at establishing a relationship between this virus and certain human cancers. These investigations, which were initiated in 1966 when the first test for detecting EBV antigens was reported (1), utilized a variety of EBV-induced antigens as targets and immunofluorescence as the primary methodology. These tests also established the importance of antibodies directed against some or all of the serologically defined EBV antigens in the diagnosis of EBV-associated diseases and for the clinical management of those patients with EBV-associated malignancies (2,3). Some of the more clinically relevant antibodies that have been identified by a number of investigators over the years are listed in Table 1. These include IgG, IgM and IgA antibodies to the different EBV antigen complexes as defined by immunofluorescence as well as antibodies to a variety of EBV-induced enzymes.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
G. Henle and W. Henle, J. Bact. 91, 1248 (1966).
G.R. Pearson, In: Current Hematology and Oncology, V.F. Fairbanks (ed.), Year Book Medical Publishers, Inc., 123 (1986).
G.R. Pearson, In Infectious Mononucleosis, D. Schlossberg (ed.), Springer Verlag, New York, 89 (1988).
G. Henle and W. Henle, Int. J. Cancer 17,1 (1976).
G.R. Pearson and J. Luka, In: Epstein-Barr Virus: Recent Advances, M.A. Epstein and B.G. Achong (eds.), Heinemann, London, 48 (1986).
M. Mackett, M.J. Conway et al., J. Virol. 64, 2545 (1990).
G. Nemerow, C. Mold et al., J. Virol. 61, 1416 (1987).
D. Oba and L.M. Hutt-Fletcher, J. Virol. 62, 1108 (1988).
M. Dolyniuk, E. Wolff et al., J. Virol. 18, 289 (1976).
K. Takada, S. Fujiwara et al., Med. Microbial Immunol. 171, 225 (1983).
M. Kishishita, J. Luka et al., Virol. 133, 363 (1984).
E.A. Emini, J. Luka et al., J.Virol. 157, 552 (1987).
M. Gong, T. Ooka et al., J. Virol. 61, 499 (1987).
G.R. Pearson, J. Luka et al., J. Virol. 160, 151 (1987).
M. Kocache and G.R. Pearson, Intervirol. 31, 1 (1990).
G.R. Pearson, In: Viral Oncology, G. Klein (ed.), Raven Press, N.Y., 739 (1980).
J. Luka, Z.E. Deeb, et al., J. Natl. Cancer Inst. 80, 1164 (1988).
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Pearson, G.R. (1991). EBV Humoral Immunology: 1966–1990. In: Ablashi, D.V., Huang, A.T., Pagano, J.S., Pearson, G.R., Yang, C.S., Ablashi, K.L. (eds) Epstein-Barr Virus and Human Disease · 1990. Experimental Biology and Medicine, vol 24. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0405-3_29
Download citation
DOI: https://doi.org/10.1007/978-1-4612-0405-3_29
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4612-6747-8
Online ISBN: 978-1-4612-0405-3
eBook Packages: Springer Book Archive