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Characterisation of the Novel “18.8” Family of Transcripts from NPC Tumours

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Book cover Epstein-Barr Virus and Human Disease · 1990

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 24))

Abstract

A comprehensive cDNA library (>2 x 106 independent clones), generated (1) from poly A-selected RNA from a North African nasopharyngeal carcinoma, designated C15, propagated in nude mice (2) has been analysed for EBV gene expression. C15 contains multiple copies of episomal circular EBV DNA but no linear (virion) DNA. It proves possible, however, by prolonged co-cultivation of the tumour with normal adult lymphocytes to produce a lymphoblastoid cell line harbouring the same virus (3). The EBV genome in C15 is similar to many human isolates in that the large deletion found in the BamHI I region of the B95.8 prototype genome is not observed.

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Author information

Authors and Affiliations

  1. Department of Virology, Royal Postgraduate Medical School, London, W12 ONN, UK

    L. Karran, Y. Gao, P. R. Smith & B. E. Griffin

  2. Department of Microbiology, University of Hong Kong, Hong Kong, China

    M. Lung & M. Ng

  3. Radiotherapy and Oncology Division, Queen Mary Hospital, Hong Kong, China

    J. Sham & D. Choy

  4. Medical and Health Department, Institute of Radiology and Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong, China

    M. Lui

Authors
  1. L. Karran
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  2. Y. Gao
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  3. P. R. Smith
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  4. M. Lung
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  5. M. Ng
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  6. J. Sham
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  7. D. Choy
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  8. M. Lui
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  9. B. E. Griffin
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Editor information

D. V. Ablashi A. T. Huang J. S. Pagano G. R. Pearson C. S. Yang Kristinë L. Ablashi

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© 1991 Springer Science+Business Media New York

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Karran, L. et al. (1991). Characterisation of the Novel “18.8” Family of Transcripts from NPC Tumours. In: Ablashi, D.V., Huang, A.T., Pagano, J.S., Pearson, G.R., Yang, C.S., Ablashi, K.L. (eds) Epstein-Barr Virus and Human Disease · 1990. Experimental Biology and Medicine, vol 24. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0405-3_25

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  • DOI: https://doi.org/10.1007/978-1-4612-0405-3_25

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6747-8

  • Online ISBN: 978-1-4612-0405-3

  • eBook Packages: Springer Book Archive

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