Abstract
The mechanism of autonomous cell growth of human lymphocytes immortalized by lymphotropic viruses is still poorly understood. In this regard, the transformation of human T lymphocytes by the retrovirus HTLV-I could represent a valuable model. HTLV-I is the causative agent of adult T-cell leukemia (ATL). In vitro, HTLV-I is able to infect CD4+ T lymphocytes, to induce constitutive expression of the p55-Tac-CD25-alpha chain of the IL-2 receptor (IL-2R), and to promote growth of the virally infected T cells. In this process, the role of several viral regulatory proteins is suspected. The p40-tax protein, encoded by the pX region of the virus, is acting as a transcription transactivator element, probably able to interact with the promoter region of cellular genes, encoding growth factor(s) and growth factor receptor(s). Whether some step of this process involves an autocrine loop implying IL-2 and high affinity IL-2R is still a matter of debate.
Keywords
- Ribonucleotide Reductase
- Cellular Gene
- Immunoregulatory Molecule
- Viral Regulatory Protein
- Encode Growth Factor
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Tursz, T. et al. (1991). Role of Cytokines in EBV-Infected Cell Growth. In: Ablashi, D.V., Huang, A.T., Pagano, J.S., Pearson, G.R., Yang, C.S., Ablashi, K.L. (eds) Epstein-Barr Virus and Human Disease · 1990. Experimental Biology and Medicine, vol 24. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0405-3_21
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DOI: https://doi.org/10.1007/978-1-4612-0405-3_21
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