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CA 125

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Part of the book series: Contemporary Biomedicine ((CB,volume 11))

Abstract

In the decade following Bast and associates’ initial reports on the usefulness of CA 125 in the management of epithelial adenocarcinomas of the ovary (Bast et al., 1981), there has been extensive investigation of the potential clinical value of CA 125 determination. In this chapter we will review the present status of CA 125 determination for screening and management of Gynecologic malignancies and will as summarize the biochemistry of CA 125 and the assay utilized to determine levels of the antigen in human fluids.

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Reference

  • Azziz, R. (1989), Obstet. Gynecol. Clin. North Am. 16, 221.

    PubMed  CAS  Google Scholar 

  • Bast, R. C., M. Feeney, H. Lazarus, L. M., Nadler, R. B. Colvin, and R. C. Knapp (1981), J. Clin. Invest. 68,1331–1337.

    Article  PubMed  Google Scholar 

  • Bast,R.C.,T.L.Klug,E.Schaetzl,P.Lavin,J. M.Niloff V. R.Zurawski,and R. C. Knapp(1984),Am. J. Obstet Gnyecol 149, 553–559.

    Google Scholar 

  • Bast, R. C., T. L. Klug, E. St. John, E. Jenison, J. M. Niloff, H. Lazarus, R. S. Berkowitz, T. Leavitt, C. T. Griffiths, L. Parker, V. R. Zurawski, and R. C. Knapp (1983), N. Engl. J. Med. 309, 883–887.

    Article  PubMed  Google Scholar 

  • Berek, J. S., R. C. Knapp, G. D. Malkasian, P. T. Lavin, C. Whitney, J. M. Niloff, and R. C. Bast (1986), Obstet. Gynecol. 67, 685–688.

    Article  PubMed  CAS  Google Scholar 

  • Chen, D., P. E. Schwartz, L. Xinguo, and Y. Zhan (1988), Obstet. Gynecol. 72, 23–27.

    PubMed  CAS  Google Scholar 

  • De Bruijn, H. W. A., S. Jager, J. M. Duk, and et al. (1986), Am. J. Obstet. Gynecol. 154,1088–1091.

    PubMed  Google Scholar 

  • Duk, J. M., J. G. Aalders, G. J. Flueren, and H. W. A. de Bruijn (1986), Am. J. Obstet. Gynecol. 155, 1097–1102.

    PubMed  CAS  Google Scholar 

  • Duk, J. M., J. G. Aalders, M. Krans, and H. W. A. de Bruijn (1989), Obstet. Gynecol. 73, 661–668.

    PubMed  CAS  Google Scholar 

  • Einhorn, N., K. Sjovall, D. A. Schoenfeld, G. Eklund, R. C. Knapp, R. C. Bast, and V. R. Zurawski (1990), Program Proc. Am. Soc. Clin. Oncol 9,157 (abstract 607).

    Google Scholar 

  • Einhorn, N., R. C. Bast, R. C., Knapp, B. Tjernberg, and V. R. Zurawski (1986b), Obstet. Gynecol. 67,414–416.

    CAS  Google Scholar 

  • Finkler, N. J., B. Benacerraft, P. T. Lavin, C. Wojciechowski, and R. C. Knapp (1988), Obstet. Gynecol. 72, 659–664.

    PubMed  CAS  Google Scholar 

  • Gadducci, A., P. Capriello, T. Bartolini, E. Barale E, and et al. (1988), Eur. J. Gynaecol. Oncol. 9, 373–376.

    PubMed  CAS  Google Scholar 

  • Goldhirsch, A., E. Berger, O. Muller, R. Maibach, S. Misteli, K. Buster, H. Roesler, and K. Brunner (1988), Oncology 45, 281–286.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs, I., I. Stabile, J. Bridges, P. Kemsley, and et al. (1988), Lancet 1 (8580), 268–271.

    Article  PubMed  CAS  Google Scholar 

  • Jager, W., C. Meier, L. Wildt, W. Sauerbrei, and N. Lang (1988), Fenil. Steril. 50(2), 223–227.

    CAS  Google Scholar 

  • Kabawat, S. E., R. C. Bast, Jr., A. K. Chan, W. R Welch, R. C. Knapp, R. B. Colvin (1983), Int. J. Gynecol. Pathol. 2, 275–285.

    Article  PubMed  CAS  Google Scholar 

  • LaHousen, M., H. Stettner, H. Pickel, W. Urdl, and P. Purstner (1987), Cancer 60, 2228–2232.

    Article  PubMed  CAS  Google Scholar 

  • Lavin, P. T., R. C. Knapp, G. Malkasian, C. W. Whitney, J. S. Berek, and R. C. Bast (1987), Obstet. Gynecol. 69, 223–227.

    PubMed  CAS  Google Scholar 

  • Lootsma-Miklosova, E., J. B. Aalders, P. H. B. Willemse, and H. W. A. de Bruijn (1987), Eur. J. Obstet. Gynecol. Reprod. Biol. 124, 231–235.

    Article  Google Scholar 

  • Malkasian, R D., R. C. Knapp, P. T. Lavin, V. R. Zurawski, K. C. Podratz, C. R. Stanhope, R. Morel, J. S. Berek, R. C. Bast, and R. E. Ritts (1988), Am. J. Obstet. Gynecol. 159, 341–346.

    PubMed  Google Scholar 

  • Malkasian, G. D., K. C. Podratz, C. R. Stanhope, R. E. Ritts, V. R. Zurawski (1986), Am. J. Obstet. Gynecol. 155, 515–518.

    PubMed  Google Scholar 

  • Marechal, F, G. Berthiot, T. Kritly, M. G. Legrand, and G. Deltour (1989), Anticancer Res. 9, 593–599.

    PubMed  CAS  Google Scholar 

  • Ng, L. W., H. D. Homesley, R. J. Barrett, C. E. Welander, and L. D. Case (1989), Am. J. Clin. Oncol. 12,106–109.

    Article  PubMed  CAS  Google Scholar 

  • Niloff. M., R. C. Bast, E. M. Schaetzl, and R. C. Knapp (1985), Am. J. Obstet. Gynecol 151, 981–986.

    PubMed  CAS  Google Scholar 

  • Niloff, J. M,., R. C. Knapp, E. Schaetzl, and R. C. Bast (1984a), Obstet. Gynecol. 64, 703–706.

    CAS  Google Scholar 

  • Niloff, J. M., T. L. Klug, E. Schaetzl, V. R. Zurawski, R C. Knapp, and R. C. Bast (1984), Am. J. Obstet. Gynecol. 148,1057–1061.

    PubMed  CAS  Google Scholar 

  • O’Connell, G. J., E. Ryan, K. J. Murphy, and M. Prefontaine (1987), Obstet. Gynecol. 70, 930–932.

    PubMed  Google Scholar 

  • Panici, P. B., G. Scambia, G. Baiocchi, L. Perrone, S. Greggi, F. Battaglia, and S. Mancuso (1988), Gynecol. Obstet. Invest. 27, 208–212.

    Article  Google Scholar 

  • Patsner, B. and W. J. Mann (1988), Cancer 62,1355–1358.

    Article  PubMed  CAS  Google Scholar 

  • Patsner, B., J. W. Orr, and W. J. Mann (1990), Am. J. Obstet. Gynecol. 162, 427–429.

    PubMed  CAS  Google Scholar 

  • Patsner, B., D. J. Tenhoppen, and W. J. Mann (1989), Eur. J. Gynecol. Oncol. 10, 322–325.

    CAS  Google Scholar 

  • Patsner, B., H. Mann, H. Cohen, and M. Loesch (1988b), Am. J. Obstet. Gynecol. 158, 399–402.

    CAS  Google Scholar 

  • Patsner, B., W. J. Mann, M. Vissicchoi, and M. Loesch (1988a), Gynecol. Oncol. 30, 98–103.

    Article  CAS  Google Scholar 

  • Pittway, D. E. and J. A. Fayez (1986), Fertil. Steril. 46, 790–794.

    Google Scholar 

  • Schwartz, P. E., S. K. Chambers, J. T. Chambers, J. Gutmann, N. Katopodis, and R. Foemmel (1987), Cancer 60, 353–361.

    Article  PubMed  CAS  Google Scholar 

  • Skates, S. and D. Singer (1990), Program Proc. Am. Soc. Clin. Oncol. 9,162, (abstract 628).

    Google Scholar 

  • Stratton, J. A., M. A. Rettenmaier, H. B. Phillips, S. Herabutya, and P. J. DiSaia (1988), Obstet. Gynecol. 71, 20–26.

    PubMed  CAS  Google Scholar 

  • Van Der Burg, M. E. L., F. B. Lammes, W. L. J. Van Putten, and G. Stoter (1988), Gynecol. Oncol. 30, 307–312.

    Article  PubMed  Google Scholar 

  • Vasilev, S. A., J. B. Schlaerth, J. Campeau, and C. P. Morrow (1988), Obstet. Gynecol. 71, 751–756.

    PubMed  CAS  Google Scholar 

  • Wik, M. R., S. E. Mills, L. P. Definer, D. J. Bollinger, and R. E. Fechner (1989), Int. J. Gynecol. Pathol. 8,179–188.

    Article  Google Scholar 

  • Zurawski, V. R., S.F. Broderick, P. Pickens, R. C. Knapp, and R. C. Bast (1987), Obstet. Gynecol. 69, 606–611.

    PubMed  Google Scholar 

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© 1992 Springer Science+Business Media New York

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Montz, F.J. (1992). CA 125. In: Sell, S. (eds) Serological Cancer Markers. Contemporary Biomedicine, vol 11. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0401-5_19

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  • DOI: https://doi.org/10.1007/978-1-4612-0401-5_19

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6745-4

  • Online ISBN: 978-1-4612-0401-5

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