Skip to main content
SpringerLink
Log in

TAG-72 as a Tumor Marker

  • Chapter
Serological Cancer Markers

Part of the book series: Contemporary Biomedicine ((CB,volume 11))

  • 124 Accesses

Abstract

In 1981, the murine IgG monoclonal antibody (MAb) B72.3 was isolated. The immunogen employed was a membrane-enriched fraction of human mammary carcinoma metastasis (Colcher et al., 1981). The B72.3-reactive antigen has subsequently been purified and characterized and has been termed TAG-72, for tumor-associated glycoprotein (Johnson et al., 1986). As a result of the purification of TAG-72, a second generation of anti-TAG-72 MAbs has been generated and characterized (Muraro et al., 1988); because the TAG-72 was obtained from a human colon cancer xenograft (LS-174T), these second-generation MAbs have been given the designation CC (i.e., CC49 and so on).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bergeron, C., P. Shatz, R. Margolese, P. Major, and A. Ferenczy (1989) Anal. Quant. Cytol. Histol. 11, 33–42.

    PubMed  CAS  Google Scholar 

  • Carrasquillo, J. A., P. Sugarbaker, D. Colcher, J. C. Reynolds, J. Esteban, G. Bryant, A. M. Keenan, P. Perentesis, K. Yokoyama, D. E. Simpson, P. Ferroni, R. Farkas, J. Schlom, and S. M. Larson (1988) J. Nucl. Med. 29,1022–1030.

    PubMed  CAS  Google Scholar 

  • Castagna, M., M. Nuti, and F. Squartini (1987) Cancer Res. 47, 902–906.

    PubMed  CAS  Google Scholar 

  • Colcher, D., P. Horan Hand, M. Nuti, and J. Schlom (1981) Proc. Natl. Acad. Sci. USA 78, 3199–3203.

    Article  PubMed  CAS  Google Scholar 

  • Colcher, D., A. M. Keenan, S. M. Larson, and J. Schlom (1984) Cancer Res. 44, 5744–5751.

    PubMed  CAS  Google Scholar 

  • Colcher, D., J. M. Esteban, J. A. Carrasquillo, P. Sugarbaker, J. C. Reynolds, G. Bryant, S. M. Larson, and J. Schlom (1987a) Cancer Res. 47,1185–1189.

    CAS  Google Scholar 

  • Colcher, D., J. Esteban, J. A. Carrasquillo, P. Sugarbaker, J. C. Reynolds, G. Bryant, S. M. Larson, and J. Schlom (1987b) Cancer Res. 47, 4218–4224.

    CAS  Google Scholar 

  • Colcher, D., D. Milenic, M. Roselli, A. Raubitschek, G. Yarranton, D. King, J. Adair, N. Whittle, M. Bodmer, and J. Schlom (1989) Cancer Res. 49, 1738–1745.

    PubMed  CAS  Google Scholar 

  • Einhorn, N., R. C. Knapp, R. C. Bast, and V. R. Zurawski, Jr. (1989) Acta Oncol. (Madr.) 28, 655–657.

    Article  CAS  Google Scholar 

  • Esteban, J. M., D. Colcher, P. Sugarbaker, J. A. Carrasquillo, G. Bryant, A. Thor, J. C. Reynolds, S. M. Larson, and J. Schlom (1987) Int. J. Cancer 39, 50–59.

    Article  PubMed  CAS  Google Scholar 

  • Friedman, E., A. Thor, P. Horan Hand, and J. Schlom (1985) Cancer Res. 45, 5648–5655.

    PubMed  CAS  Google Scholar 

  • Gero, E. J., D. Colcher, P. Ferroni, R. Melsheimer, S. Giani, J. Schlom, and P. Kaplan (1989) J. Clin. Lab. Anal. 3, 360–369.

    Article  PubMed  CAS  Google Scholar 

  • Greiner, J. W., P. B. Fisher, S. Pestka, and J. Schlom (1986) Cancer Res. 46, 4984–4990.

    PubMed  CAS  Google Scholar 

  • Greiner, J. W., F. Guadagni, R. V. Smalley, D. Goldstein, E. C. Borden and J. Schlom (1990) AACR Proceedings 31, 1672 (Abstract).

    Google Scholar 

  • Greiner, J. W., P. Horan Hand, P. Noguchi, P. Fisher, S. Pestka, and J. Schlom(1984) Cancer Res. 44, 3208–3214.

    PubMed  CAS  Google Scholar 

  • Greiner, J. W., F. Guadagni, P. Noguchi, S. Pestka, D. Colcher, P. B. Fisher, and J. Schlom (1987) Science 235, 895–898.

    Article  PubMed  CAS  Google Scholar 

  • Guadagni, F., J. Schlom, W. W. Johnston, C. A. Szpak, D. Goldstein, R. Smalley, J. Simpson, E. C. Borden, S. Pestka, and J. W. Greiner (1989) J. Natl. Cancer Inst. 81, 502–512.

    Article  PubMed  CAS  Google Scholar 

  • Horan Hand, P., D. Colcher, D. Salomon, J. Ridge, P. Noguchi, and J. Schlom (1985) Cancer Res. 45, 833–840.

    Google Scholar 

  • Hutzell, P., S. Kashmiri, D. Colcher, J. Primus, P. Horan Hand, M. Roselli, G. Yarranton, M. Bodmer, N. Whittle, D. King, C. C. Loullis, D. W. McCoy, R. Callahan, and J. Schlom (1991) Cancer Res. 51,181–189.

    PubMed  CAS  Google Scholar 

  • Johnson, V. G., J. Schlom, A. J. Paterson, J. Bennett, J. L. Magnani, and D. Colcher (1986) Cancer Res. 46, 850–857.

    PubMed  CAS  Google Scholar 

  • Johnston, W. W., C. A. Szpak, S. C. Lottich, A. Thor, and J. Schlom (1985) Cancer Res. 45,1894–1900.

    PubMed  CAS  Google Scholar 

  • Johnston, W. W., C. A. Szpak, A. Thor, and J. Schlom (1986a) Cancer Res. 46, 6462–6470.

    CAS  Google Scholar 

  • Johnston, W. W., C. A. Szpak, S. C. Lottich, A. Thor, and J. Schlom (1986b) Hum. Pathol. 17, 501–513.

    Article  CAS  Google Scholar 

  • Katari, R. S., P. D. Fernsten, and J. Schlom (1990) Cancer Res. 50, 4885–4890.

    PubMed  CAS  Google Scholar 

  • Kavanagh, J. J., M. Rosenblum, T. Burke, L. Lamki, L. Murrary, J. Shanken, L. Thompson, and J. T. Wharton (1990) AACR Proceedings 31, 1116 (Abstract).

    Google Scholar 

  • Kjeldsen, T., H. Clausen, S. Hirohashi, T. Ogawa, H. Iijima, and S Hakomori (1988) Cancer Res. 48, 2114–2120.

    Google Scholar 

  • Kline, T. S., J. Lundy, and M. Lozowski (1989) Cancer 63, 2253–2256.

    Article  PubMed  CAS  Google Scholar 

  • Klug, T. L., M. A.Sattler, D. Colcher, and J. Schlom (1986) Int. J. Cancer 38, 661–669.

    Article  PubMed  CAS  Google Scholar 

  • Kuroki, A., P. Fernsten, D. Wunderlich, D. Colcher, J. F. Simpson, D. J. Poole, T. G. Ooley, and J. Schlom (1990) Cancer Res. (in press).

    Google Scholar 

  • Kurosaka, A., H. Kitagawa, S. Fukui, Y. Numata, H. Nakada, I. Funakoshi, T. Kawasaki, T. Ogawa, H. Iijama, and I. Yamashina (1988) J. Biol. Chem. 263, 8724–8726.

    PubMed  CAS  Google Scholar 

  • Lastoria, S., P. D’Amico, L. Mansi, G. G. Giordano, R. Rossiello, J. Schlom, E. Pace, N. Panza, G. Pacilio, and M. Salvatore (1988) Nucl. Med. Comm. 9, 347–356.

    Article  CAS  Google Scholar 

  • Lundy, J., M. Lozowski, Y. Mishriki (1986) Ann. Surg. 203, 399–402.

    Article  PubMed  CAS  Google Scholar 

  • Lyubsky, S., J. Madariaga, M. Lozowski, Y. Mishriki, A. Schuss, S. Chao, and J. Lundy (1988) Am. J. Clin. Pathol. 89,160–167.

    PubMed  CAS  Google Scholar 

  • Maguire, R. T., R. F. Schmelter, V. L. Pascucci, and J. J. Conklin (1989) Antibody Immunoconjugates Radiopharm. 2, 257–269.

    Google Scholar 

  • Martin, E. W., C. M. Mojzisik, G. H. Hinkle, J. Sampsel, M. A. Siddiqi, S. E. Tuttle, B. Sickle-Santanello, D. Colcher, M. O. Thurston, J. G. Bell, W. B. Farrar, and J. Schlom (1988) Am. J. Surg. 156, 386–392.

    Article  PubMed  Google Scholar 

  • Martin, S. E., S. Moshiri, A. Thor, V. Vilasi, E. W. Chu, and J. Schlom (1986) Am. J. Clin. Pathol. 86,10–18.

    PubMed  CAS  Google Scholar 

  • Massod, S. (1989), American Society of Clinical Pathologists and the College of American Pathologists (Abstract).

    Google Scholar 

  • Massod, S. (1990), American Society of Clinical Pathologists and the College of American Pathologists 438,14 (Abstract).

    Google Scholar 

  • Molinolo, A., J. F. Simpson, A. Thor, and J. Schlom (1990) Cancer Res. 50, 1291–1298.

    PubMed  CAS  Google Scholar 

  • Muraro, R., M. Kuroki, D. Wunderlich, D. J. Poole, D. Colcher, A. Thor, J. W. Greiner, J. F. Simpson, A. Molinolo, P. Noguchi, and J. Schlom (1988) Cancer Res. 48, 4588–4596.

    PubMed  CAS  Google Scholar 

  • Nance, K. V. and J. F. Silverman (1990), American Society of Clinical Pathologists and the College of American Pathologists, 436,4 (Abstract).

    Google Scholar 

  • Natali, P. G., M. Mottolese, R. Perrone Donnorso, R. Buffa, G. Bussolati, G. Coggi, G. Corradi, L. Coascia-Porrazzi, M. Ferretti, E. Rondanelli, M. Castagna, A. Vecchione, and G. A. Siccardi (1990) Int. J. Cancer 45, 12–15.

    Article  PubMed  CAS  Google Scholar 

  • Ness, M. J., P. M. Pour, M. A. Tempero, and J. Linder (1988) Mod. Pathol. 1, 279–283.

    PubMed  CAS  Google Scholar 

  • Nieroda, C., C. Mojzisik, A. Sardi, W. Farrar, G. Hinkle, A. Siddiqi, P. J. Ferra, A. James, J. Schlom, M. Thurston, and E. Martin (1989) Surg. Gynecol. Obstetr. 169, 35–40.

    CAS  Google Scholar 

  • Nuti, M., M. Mottolese, M. Viola, R. Perrone Donnorso, J. Schlom, and P. G. Natali (1986) Int. J. Cancer 37, 493–498.

    Article  PubMed  CAS  Google Scholar 

  • Nuti, M., Y. A. Teramoto, R. Mariani-Costantini, P. Horan Hand, D. Colcher, and J. Schlom (1982) Int. J. Cancer 29, 539–545.

    Article  PubMed  CAS  Google Scholar 

  • Ohuchi, N., J. Simpson, D. Colcher, and J. Schlom (1987) Int. J. Cancer 40, 726–733.

    Article  PubMed  CAS  Google Scholar 

  • Ohuchi, N., K. Takahashi, N. Matoba, T. Sato, Y. Taira, N. Sakai, M. Masuda, and S. Mori (1989) Jpn. J. Clin. Oncol. 19, 242–248.

    PubMed  CAS  Google Scholar 

  • Ohuchi, N., E. Gero, S. Mori, M. Akimoto, N. Matoba, T. Nishihira, K. Nirayama, D. Colcher, and J. Schlom (1990) J. Tumor Marker Oncol. 5 1–10.

    Google Scholar 

  • Ordonez, N. G. (1989) Am. J. Surg. Pathol. 13, 276–291.

    PubMed  CAS  Google Scholar 

  • Paterson, A. J., J. Schlom, H. F. Sears, J. Bennett, and D. Colcher (1986) Int. J. Cancer 37,659–666.

    Article  PubMed  CAS  Google Scholar 

  • Primus, F. J., T. K. Pendurthi, P. Hutzell, S. Kashmiri, D. Slavin, R. Callahan, and J. Schlom (1990) Cancer Immunol. Immunother. 31, 349–357.

    Article  PubMed  CAS  Google Scholar 

  • Radio, S. J., S. I. Rennard, A. Kessinger, W. P. Vaughan, and J. Linder (1989) Arch. Path. Lab. Med. 113, 333–336.

    PubMed  CAS  Google Scholar 

  • Raubitschek, A., D. Colcher, S. Lastoria, P. Perentesis, R. Neumann, S. Larson, J. Reynolds, P. Sugarbaker, J. Schlom, and J. Carrasquillo (1988, September) Second Conference on Radio immunodetection and Radioimmunotherapy of Cancer, Princeton, NJ (Abstract).

    Google Scholar 

  • Sheer, D. G., J. Schlom, and H. L. Cooper (1988) Cancer Res. 48, 6811–6818.

    PubMed  CAS  Google Scholar 

  • Sickle-Santanello, B. J., P. J. O’Dwyer, C. Mojzisik, S. E. Tuttle, G. H. Hinkle, M. Rouseau, J. Schlom, D. Colcher, M. O. Thurston, C. Nieroda, A. Sardi, J. P. Minton, and E. W. Martin (1987) Dis. Colon Rectum 30, 761–764.

    Article  PubMed  CAS  Google Scholar 

  • Soper, J. T., V. J. Hunter, L. Daly, M. Tanner, W. T. Creasman, and R. C. Bast, Jr. (1990) Obstet. Gynecol. 75, 249–254.

    PubMed  CAS  Google Scholar 

  • Stanick, D., A. Schuss, Y. Mishriki, S. Chao, A. Thor, and J. Lundy (1988) Cancer Invest. 6, 279–287.

    Article  PubMed  CAS  Google Scholar 

  • Stramignoni, D., R. Bowen, B. Atkinson, and J. Schlom (1983) Int. J. Cancer 31, 543–552.

    Article  PubMed  CAS  Google Scholar 

  • Szpak, C. A., W. W. Johnston, V. Roggli, J. Kolbeck, C. Lottich, R. Vollmer, A. Thor, and J. Schlom (1986), Am.J. Pathol. 122, 252–260.

    PubMed  CAS  Google Scholar 

  • Szpak, C. A., J. T. Soper, A. Thor, J. Schlom, and W. W. Johnston (1989) Acta Cytol. 33, 205–214.

    PubMed  CAS  Google Scholar 

  • Thor, A., N. Ohuchi, C. A. Szpak, W. W. Johnston, and J. Schlom (1986) Cancer Res. 46, 3118–3124.

    PubMed  CAS  Google Scholar 

  • Thor, A., M. J. Viglione, R. Muraro, N. Ohuchi, J. Schlom, and F. Gorstein (1987) Int. J. Gynecol. Pathol 6,235–247.

    Article  PubMed  CAS  Google Scholar 

  • Thor, A., S. H. Itzkowitz, J. Schlom, Y. S. Kim, and S. Hanauer (1989) Int. J. Cancer 43, 810–815.

    Article  PubMed  CAS  Google Scholar 

  • Tuttle, S. E., S. D. Jewell, C. Mojzisik, G. H. Hinkle, D. Colches, J. Schlom, and E. W. Martin (1988) Int. J. Cancer 42, 352–358.

    Article  PubMed  CAS  Google Scholar 

  • Vick, W. W., C. J. Wikstrand, D. E. Bullard, J. Kemshead, H. B. Coakham, J. Schlom, W. W. Johnston, D. D. Bigner, and S. H. Bigner (1987) Acta Cytol. 31, 815–824.

    PubMed  CAS  Google Scholar 

  • Warnock, M. L., A. Stoloff, and A. Thor (1988) Am. J. Pathol. 133, 30–38.

    PubMed  CAS  Google Scholar 

  • Whittle, N., J. Adair, C. Lloyd, L. Jenkins, J. Schlom, A Raubitschek, D. Colcher, and M. Bodmer (1987) Protein Eng. 1, 499–505.

    Article  PubMed  CAS  Google Scholar 

  • Wolf, B. C., J. C. D’Emilia, R. R. Salem, D. DeCoste, H. F. Sears, L. S. Gottlieb, and G. D. Steele, Jr. (1989) J. Natl. Cancer Inst. 81,1913–1917.

    Article  PubMed  CAS  Google Scholar 

  • Xu, M., F. X. Real, S. Welt, M. H. Schussler, H. F. Oettgen, and L. J. Old (1989) Int. J. Cancer 44, 985–989.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Jeffrey Schlom
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David Colcher
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Diane E. Milenic
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Patricia Horan Hand
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. John W. Greiner
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masahide Kuroki
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ann Thor
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Alfredo Molinolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Noriaki Ohuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX, USA

    Stewart Sell

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

Schlom, J. et al. (1992). TAG-72 as a Tumor Marker. In: Sell, S. (eds) Serological Cancer Markers. Contemporary Biomedicine, vol 11. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0401-5_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-0401-5_18

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6745-4

  • Online ISBN: 978-1-4612-0401-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation