Effects of Acute Hypertension on Pial Artery Tone
The arteries that course along the surface of the brain normally operate in a state of partial, sustained constriction (tone) from which either dilation or constriction may occur, as required to maintain normal blood flow. Although its extent varies with arterial size and experimental conditions, basal tone appears to be a widespread vascular phenomenon that has been observed in cerebral arteries from a number of species, in vivo and in vitro (e.g., refs. 1-3). Some degree of arterial constriction is requisite for cerebral blood flow (CBF) autoregulation, which is principally effected by arterial dilation to decreases, and by constriction to increases in transmural pressure.
KeywordsHydrogen Peroxide Hydroxyl Superoxide Angiotensin Prostaglandin
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