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The Tachykinin Receptors pp 125–163Cite as

Autoradiographic Localization of Receptors in Peripheral Tissues

  • Chapter

Part of the book series: The Receptors ((REC))

Abstract

Autoradiography incorporates the fundamental principles of radioligand binding and photographic techniques. The ideal requisites for a peptide radioligand used in autoradiography are:

  1. 1.

    High-affinity

  2. 2.

    Absolute receptor selectivity

  3. 3.

    Low nonspecific binding

  4. 4.

    Resistance to enzymatic degradation; and

  5. 5.

    Biological activity

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References

  • Angus, J. A., Cocks, T. M., and Satoh, K. (1986) Adrenoceptors and endothelium-dependent relaxation in canine large arteries.Br. J. Pharmacol. 88, 767–777.

    Article  PubMed  CAS  Google Scholar 

  • Badgery-Parker, T., Zeng, X.-P., Lavielle, S., and Burcher, E. (1993) A novel, selective radioligand, [125I]-[Lys5,Tyr(I2 7,MeLeu9,Nle10]-NKA(4–10), for the tachykinin N-2 receptor.Regul. Pept. 46, 455–457.

    Article  PubMed  CAS  Google Scholar 

  • Barnes P. J., Baraniuk, J. N., and Belvisi, M. G. (1991) Neuropeptides in the respiratory tract. Part 1.Am. Rev. Respir. Dis. 144, 1187–1198.

    Article  PubMed  CAS  Google Scholar 

  • Bartho, L. and Holzer, P. (1985) Search for a physiological role of substance P in gastrointestinal motility.Neuroscience 16, 1–32.

    Article  PubMed  CAS  Google Scholar 

  • Black, J. L., Diment, L. M., Alouan, L. A., Johnson, P. R. A., Armour, C. L., BadgeryParker, T., and Burcher, E. (1992) Tachykinin receptors in rabbit airways-characterisation using functional, autoradiographic and binding studies.Br. J. Pharmacol. 107, 429–436.

    Article  PubMed  CAS  Google Scholar 

  • Black, J., Diment, L, Armour, C. L., Alouan, L., and Johnson, P., (1990) Distribution of substance P receptors in rabbit airways, functional and autoradiographic studies.J. Pharmacol. Exp. Ther. 253, 381–386.

    PubMed  CAS  Google Scholar 

  • Buck, S. H. and Burcher, E. (1985) The rat submaxillary gland contains predominantly P-type tachykinin binding sites.Peptides 6, 1079–1084.

    Article  PubMed  CAS  Google Scholar 

  • Buck S. H., Helke C. J., Burcher E., Shults C. W., and O’Donohue T. L. (1986) Pharmacologic characterization and autoradiographic distribution of binding sites for iodinated tachykinins in rat central nervous system.Peptides 7, 1109–1120.

    Article  PubMed  CAS  Google Scholar 

  • Buck, S. H. and Shatzer S. A. (1988) Agonist and antagonist binding to tachykinin peptide NK-2 receptors.Life Sci. 42, 2701–2708.

    Article  PubMed  CAS  Google Scholar 

  • Burcher, E., Atterhög, J. H., Pernow, B., and Rosell, S. (1977) Cardiovascular effects of Substance P; regional differences in blood flow and effect on the heart, inNobel Symposium on Substance PVon Euler, U. S. and Pernow, B., eds.), Raven, New York, pp. 261–268.

    Google Scholar 

  • Burcher, E., Badgery-Parker, T., Zeng, X.-P., and Lavielle, S. (1993) Characterization of a novel, selective radioligand, [125I][Lys5,Tyr(I2 7,MeLeu9,Nle10]-NKA(4–10), for the tachykinin NK2 receptor in rat fundus.Eur. J. Pharmacol. 233, 201–207.

    Article  PubMed  CAS  Google Scholar 

  • Burcher, E. and Bornstein, J. C. (1988) Localization of substance P binding sites in submucous plexus of guinea pig ileum, using whole mount autoradiography.Synapse 2, 232–239.

    Article  PubMed  CAS  Google Scholar 

  • Burcher, E. and Buck, S. H. (1986) Multiple tachykinin binding sites in hamster, rat and guinea pig urinary bladder.Eur. J. Pharmacol. 128, 165–178.

    Article  PubMed  CAS  Google Scholar 

  • Burcher, E., Buck, S. H., Lovenberg, W., and O’Donohue, T. L. (1986) Characterization and autoradiographic localization of multiple tachykinin binding sites in gastrointestinal tract and bladder.J. Pharmacol. Exp. Ther. 236, 819–831.

    PubMed  CAS  Google Scholar 

  • Burcher, E. and Mussap, C. J. (1991) Neuropeptide y-prefering subtypes of NK2 receptors in rat fundus and dog urinary bladder.Soc. Neurosci. Abstr. 17, 805.

    Google Scholar 

  • Burcher, E., Mussap, C. J., Geraghty, D. P., McClure-Sharp, J. M., and Watkins, D. J. (1991) Concepts in characterization of tachykinin receptors.Ann. NYAcad. Sci. 632, 123–136.

    Article  CAS  Google Scholar 

  • Burcher, E., Shults, C. W., Buck, S. H., Chase, T. N., and O’Donohue, T. L. (1984) Autoradiographic distribution of substance K binding sites in rat gastrointestinal tract: a comparison with substanceP. Eur. J. Pharmacol. 102, 561–562.

    Article  CAS  Google Scholar 

  • Burcher, E., Taylor, C., and O’Flynn, N. M. (1990) Substance P binding sites associated with blood vessels in rat female reproductive tract.Clin. Exp. Pharmacol. Physiol.Suppl. 17, 90.

    Google Scholar 

  • Burcher, E., Watkins, D. J., and O’Flynn, N. (1989) Autoradiographic localization of both substance P and neurokinin A binding sites in guinea pig lung.Pulmonary Pharmacol. 1, 201–203.

    Article  CAS  Google Scholar 

  • Burcher, E., Zeng, X.-P. and Moore, K. H. (1993) Characterization and autoradio-graphic localization of tachykinin N-2 receptors in human urinary bladder.Neuropeptides 24, 237.

    Article  Google Scholar 

  • Burnstock, G. (1987) Dual control of blood pressure by purines, inPharmacologyRand, M. J. and Raper, C., eds), Exerpta Medica Int. Cong. series 750, Elsevier, Amsterdam, pp. 245–253.

    Google Scholar 

  • Carstairs, J. R. and Barnes, P. J. (1986) Autoradiographic mapping of substance P receptors in lung.Eur. J. Pharmacol. 127, 295–296.

    Article  Google Scholar 

  • Chassaing, G., Lavielle, S., Brunissen, A., Carruette, A., Garret, C., Petitet, F., Saffroy, M., Beaujouan, J.-C., Torrens, Y., and Glowinski, J. (1992) [Pro9]SP and [pGlu6,Pro9]SP(6–11) interact with two different receptors in the guinea pig ileum as demonstrated with new SP antagonists.Neuropeptides 23, 73–79.

    Article  PubMed  CAS  Google Scholar 

  • Deguchi, M., Niwa, M., Shigematsu, K., Fujii, T., Namba, K., and Ozaki, M. (1989) Specific [125I]Bolton-Hunter substance P binding sites in human and rat skin.Neurosci. Lett. 99, 287–292.

    Article  PubMed  CAS  Google Scholar 

  • Denis, P., Fardin, V., Nordmann, J. P., Elena, P. P., Laroche, L., Saraux, H., and Rostene, W. (1991) Localization and characterization of substance P binding sites in rat and rabbit eyes.Invest. Opthalmol. Vis. Sci. 32, 1894–1902.

    CAS  Google Scholar 

  • Ferguson, M. and Bell, C. (1985) Substance P-immunoreactive nerves in the rat kidney.Neurosci. Lett. 60, 183–188.

    Article  PubMed  CAS  Google Scholar 

  • Fischer, A., Kummer, W., Courand, J. Y., Adler, D., Branscheid, D., and Heym, C. (1992) Immunohistochemical localization of receptors for vasoactive intestinal polypeptide and substance P in human trachea.Lab. Inv. 67, 387–393.

    CAS  Google Scholar 

  • Fisher, L. and Pennefather, J. N. (1992) The inactivation of neurokinin A on the rat uterus is modified by oestrogen treatment.Regul. Pept.Suppl. 1, S55.

    Google Scholar 

  • Foster, A. C. and Tridgett, R. (1988) Comparision of the binding of radiolabelled neurokinin A and eledoisin in rat cortex synaptic membranes.Br. J. Pharmacol. 94, 602–608.

    Article  PubMed  CAS  Google Scholar 

  • Frossard, N. and Advenier, C. (1991) Tachykinin receptors and the airways.Life Sci. 49, 1941–1953.

    Article  PubMed  CAS  Google Scholar 

  • Furchgott, R. F. (1984) The role of endothelium in the responses of vascular smooth muscle to drugs.Annu. Rev. Pharmacol. Toxicol. 24, 175–197.

    Article  PubMed  CAS  Google Scholar 

  • Furness, J. B., Papka, R. E., Della, N. G., Costa, M., and Eskay, R. L. (1982) Substance P like imnunoreactivity in nerves associated with the vascular system of guinea pigs.Neuroscience 7, 447–459.

    Article  PubMed  CAS  Google Scholar 

  • Gates, T. S., Zimmerman, R. P., Mantyh, C. R., Maggio, J. E., Walton, M. L., Passaro, E. P., Jr., and Mantyh, P. W. (1988) Substance P and substance K receptor binding sites in the human gastrointestinal tract: localization by autoradiography.Peptides 9, 1207–1219.

    Article  PubMed  CAS  Google Scholar 

  • Geraghty, D. P., Mussap, C. J., and Burcher, E. (1992) Radioiodinated substance P, neurokinin A and eledoisin bind predominantly to NK1 receptors in guinea pig lung.Mol. Pharmacol. 41, 147–153.

    PubMed  CAS  Google Scholar 

  • Goldie, R. G. (1990) Receptors in asthmatic airways.Am. Rev. Resp. Dis. 141, S151–156.

    PubMed  CAS  Google Scholar 

  • Gronblad, M., Konntinen, Y. T., Korkala, O., Liesi, P., Hukkanen, M., and Polak, J. (1988) Neuropeptides in the synovium of patients with rheumatoid arthritis and osteoarthritis.J. Rheumatol. 15, 1807–1810.

    PubMed  CAS  Google Scholar 

  • Gullner, H. G., Campbell, W. B., and Pettinger, W. A. (1979) Effects of substance P on renin release and renal function in anaesthetized dogs.Life Sci. 24, 237–246.

    Article  PubMed  CAS  Google Scholar 

  • Gunasena, K., Morrison, J. F. B., Nimmo, A. J., and Whitaker, E.M. (1989) The effects of oestradiol and progesterone on neurokinin receptors in rat uterus.J. Physiol. 418, 75P (abstract).

    Google Scholar 

  • Herkenham, M. and Pert, C.B. (1982) Light microscopic localization of brain opiate receptors: a general autoradiographic method which preserves tissue quality.J. Neurosci. 2, 1129–1149.

    PubMed  CAS  Google Scholar 

  • Hokfelt, T., Johansson, O., Kellerth, J.-O., Ljungdahl, A., Nilsson, G., Nygards, A., and Pernow, B. (1977) Immunohistochemical distribution of substance P, inNobel Symposium on Substance PVon Euler, U. S. and Pernow, B., eds.), Raven, New York, pp. 117–145.

    Google Scholar 

  • Holzer, P. (1988) Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-relted peptide and other neuropeptides.Neuroscience 24, 739–768.

    Article  PubMed  CAS  Google Scholar 

  • Holzer-Petsche U. and Lembeck F. (1984) Systemic capsaicin treatment impairs the micturition reflex in therat. Br. J. Pharmacol. 83, 935–941.

    Article  CAS  Google Scholar 

  • Hoover, D. B. and Hancock, J. C. (1987) Autoradiographic localization of substance P binding sites in guinea pig airways.J. Auton. Nerv. Syst. 19, 171–174.

    Article  PubMed  CAS  Google Scholar 

  • James, S. and Burnstock, G. (1988) Autoradiographic localization of binding sites for ’25I-substance P on neurones from cultured rat superior cervical ganglion.Brain Res. 458, 205–211.

    Article  PubMed  CAS  Google Scholar 

  • Korman, L. Y., Sayadi, H., Bass, B., Moody, T. W., and Harmon, J. W. (1989) Distribution of vasoactive intestinal polypeptide and substance P receptors in human colon and small intestine.Dig. Dis. Sci. 34, 1100–1108.

    Article  PubMed  CAS  Google Scholar 

  • Kuhar, M. J. (1985) Receptor localization with the microscope, inNeurotransmitter Receptor Binding, 2nd ed. (Yamamura, H. I., Enna, S. J., and Kuhar, M. J., eds.), Raven, New York, pp. 153–176.

    Google Scholar 

  • Kuhar, M. J., De Souza, E. B., and Unnerstall, J. R. (1986) Neurotransmitter receptor mapping by autoradiography and other methods.Annu. Rev. Neurosci. 9, 27–59.

    Article  PubMed  CAS  Google Scholar 

  • Lee C.-M., Javitch J. A., and Snyder S. H. (1983) H-substance P binding to salivary gland membranes. Regulation by guanyl nucleotides and divalent cations.Mol. Pharmacol. 23, 563–569.

    PubMed  CAS  Google Scholar 

  • Lembeck, F., Donnerer, J., Tsuchiya, M., and Nagahisa, A. (1992) The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation.Br. J. Pharmacol. 105, 527–530.

    Article  PubMed  CAS  Google Scholar 

  • Lembeck, F. and Holzer, P. (1979) Substance P as neurogenic mediator of antidromic vasodilatation and neurogenic plasma extravasation.Naunyn Schmiedeberg’s Arch. Pharmacol. 310, 175–183.

    Article  CAS  Google Scholar 

  • Lew, R., Geraghty, D. P., Drapeau, G., Regoli, D., and Burcher, E. (1990) Binding characteristics of [[12SI1-Bolton-Hunter Sar9,Met(02)“ 1-substance P, a new selective radioligand for the NK1 receptor.Eur. J. Pharmacol. 184, 97–108.

    Article  PubMed  CAS  Google Scholar 

  • Liang, T. and Cascieri, M. A. (1981) Substance P receptor on parotid cell membranes.J. Neurosci.1, 1133–1141.

    PubMed  CAS  Google Scholar 

  • Lundberg, J. M., Hokfelt, T., Martling, C. R., Saria, A., and Cuello, C. (1984) Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man.Cell Tissue Res. 236, 251–261.

    Google Scholar 

  • Maggi, C. A. (1991) The role of peptides in the regulation of the micturition reflex: an update.Gen. Pharmacol. 22, 1–24.

    Article  PubMed  CAS  Google Scholar 

  • Maggi, C. A., Barbanti, G., Santicioli, P., Beneforti, P., Misuri, D., Meli, A., and Turino, D. (1989) Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex in humans.J. Urol. 192, 150–154.

    Google Scholar 

  • Mantyh, P. W. (1991) Substance P and the inflammatory and immune response.Ann. NYAcad. Sci. 632, 263–271.

    Article  CAS  Google Scholar 

  • Mantyh, P. W., Catton, M. D., Allen, C. J., Labenski, M. E., Maggio, J. E., and Vigna, S. R. (1992) Receptor binding sites for cholecystokinin, galanin, somatostatin, substance P and vasoactive intestinal polypeptide in sympathetic ganglia.Neuroscience 46, 739–754.

    Article  PubMed  CAS  Google Scholar 

  • Mantyh, C. R., Gates, T. S., Zimmerman, R. P., Welton, M. L., Passaro, E. P., Jr., Vigna, S. R., Maggio, J. E., Kruger, L., and Mantyh, P. W. (1988a) Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease.Proc. Natl. Acad. Sci. 85, 3235–3239.

    Article  CAS  Google Scholar 

  • Mantyh, P. W., Goedert, M., and Hunt, S. P. (1984) Autoradiographic visualization of receptor binding sites for substance P in the gastrointestinal tract of the guinea pig.Eur. J. Pharmacol. 100, 133–134.

    Article  PubMed  CAS  Google Scholar 

  • Mantyh, P. W., Mantyh, C. R., Gates, T., Vigna, S. R., and Maggio, J. E. (1988b) Receptor binding sites for substance P and substance K in the canine gastrointestinal tract and their possible role in inflammatory bowel disease.Neuroscience 25, 817–837.

    Article  CAS  Google Scholar 

  • Mantyh, P. W., Gates, T., Mantyh, C. R., and Maggio, J. E. (1989) Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues.J. Neurosci. 9, 258–279.

    PubMed  CAS  Google Scholar 

  • Marshall, K. W., Chiu, B., and Inman, R. D. (1990) Substance P and arthritis: analysis of plasma and synovial fluid levels.Arthritis Rheum. 33, 87–90.

    Article  PubMed  CAS  Google Scholar 

  • Mastrangelo, D., Mathison, R., Huggel, H. G., Dion, S., D’Orleans-Juste, P., Rhaleb, N. E., Drapeau, G., Rovero, P., and Regoli, D. (1986) The rat isolated portal vein: A preparation sensitive to neurokinins, particularly neurokininB. Eur. J. Pharmacol. 134, 321–326.

    Article  Google Scholar 

  • Mizrahi, J., Dion, S., D’Orleans-Juste, P., Escher, E., Drapeau, G., and Regoli, D. (1985) Tachykinin receptors in smooth muscles: A study with agonists (substance P, neurokinin A) and antagonists.Eur. J. Pharmacol. 118, 25–36.

    Article  PubMed  CAS  Google Scholar 

  • Morrison, J. F. B., Nimmo, A. J., and Whitaker, E. M. (1989) The effect of neonatal capsaicin treatment on the distribution of neurokinin binding sites in rat bladder.J. Physiol. 423, 79P (abstract).

    Google Scholar 

  • Mussap, C. J. (1992Characterisation of tachykinin receptors: radioligand binding,functional and autoradiographic studies.PhD thesis, University of New South Wales, Australia.

    Google Scholar 

  • Mussap, C. J. and Burcher, E. (1990) Bolton-Hunter scyliorhinin II: a novel, selective radioligand for the tachykinin NK3 receptor in rat brain.Peptides 11, 827–836.

    Article  PubMed  CAS  Google Scholar 

  • Mussap, C. J. and Burcher, E. (1991) Multiple tachykinin receptors in rat submandibular gland.Ann. NY Acad. Sci. 632, 447–452.

    Article  PubMed  CAS  Google Scholar 

  • Mussap, C. J. and Burcher, E. (1993) Characterization and autoradiographic localization of tachykinin receptors in rat fundus.J. Pharmacol. Exp. Ther. 266, 1043–1053.

    PubMed  CAS  Google Scholar 

  • Mussap, C.J., Geraghty, D.P., and Burcher, E. (1993) Tachykinin receptors: a radio-ligand binding perspective.J. Neurochem. 60, 1987–2009.

    Article  PubMed  CAS  Google Scholar 

  • Mussap, C. J., Lew, R., and Burcher, E. (1989) The autoradiographic distribution of substance P binding sites in guinea pig vas deferens is altered by capsaicin pretreatment.Eur. J. Pharmacol. 168, 337–345.

    Article  PubMed  CAS  Google Scholar 

  • Nantel, F., Roussi, N., Rhaleb, N.-E., Dion, S., Drapeau, G., and Regoli, D. (1990) The rabbit jugular vein is a contractile NK-1 receptor system.Eur. J. Pharmacol. 179, 457–462.

    Article  PubMed  CAS  Google Scholar 

  • Nimmo, A. J., Whitaker, E. M., Carstairs, J.R., and Morrison, J. F. B. (1989) The autoradiographic localization of calcitonin gene-related peptide and substance P receptors in human fallopian tube.Quart. J. Exp. Physiol. 74, 955–958.

    CAS  Google Scholar 

  • Nimmo, A. J., Morrison, J. F. B., and Whitaker, E. M. (1988) A comparison of the distribution of substance P and calcitonin gene-related peptide receptors in the rat bladder.Quart. J. Exp. Physiol. 73, 789–792.

    CAS  Google Scholar 

  • Niwa, M., Shigematsu, K., Plunkett, L., and Saavedra, J. (1985) High-affinity substance P binding sites in rat sympathetic ganglia. Am.J. Physiol. 249, H694–H697.

    PubMed  CAS  Google Scholar 

  • Osborne, N. N. (1984) Substance P in the bovine retina: localization, identification, release, uptake and receptor analysis.J. Physiol. 349, 83–93.

    PubMed  CAS  Google Scholar 

  • O’Flynn, N. M., Helme, R. D., Watkins, D. J., and Burcher, E. (1989) Autoradio-graphic localization of substance P binding sites in rat footpad skin.Neurosci. Lett. 106, 43–48.

    Article  PubMed  Google Scholar 

  • Payan, D. G. (1989) Neuropeptides and inflammation: The role of substance P.Annu. Rev. Med. 40, 341–352.

    Article  PubMed  CAS  Google Scholar 

  • Papka, R. E., Cotton, J. P., and Traurig, H. H. (1985) Comparative distribution of neuropeptide tyrosine-, vasoactive intestinal polypeptide-, substance P-immunoreactive, acetylcholinesterase-positive and noradrenergic nerves in the reproductive tract of the female rat.Cell Tissue Res. 242, 475–490.

    Article  PubMed  CAS  Google Scholar 

  • Pennefather, J. N., Zeng, X.-P., Gould, D., Hall, S., and Burcher, E. (1993) Mammalian tachykinins stimulate rat uterus by activating tachykinin NK-2 receptors.Peptides 14, 169–174.

    Article  PubMed  CAS  Google Scholar 

  • Pernow, B. (1983) Substance P.Pharmacol. Rev. 36, 85–141.

    Google Scholar 

  • Petitet, F., Beaujouan, J.-C., Saffroy, M., Torrens, Y., Chassaing, G., Lavielle, S., Besseyre, J., Garret, C., Carruette, A., and Glowinski, J. (1991) Further demonstration that [Pro9)-substance P is a potent and selective ligand of NK-1 tachykinin receptors.J. Neurochem. 56, 879–889.

    Article  PubMed  CAS  Google Scholar 

  • Petitet, F., Saffroy, M., Torrens, Y., Lavielle, S., Chassaing, G., Loeuillet, D., Glowinski, J., and Beaujouan, J.-C. (1992) Possible existence of a new tachykinin receptor subtype in the guinea pig ileum.Peptides 13, 383–388.

    Article  PubMed  CAS  Google Scholar 

  • Popper, P., Mantyh, C. R., Vigna, S. R., Maggio, J. E., and Mantyh, P. W. (1988) The localization of sensory nerve fibers and receptor binding sites for sensory neuropeptides in canine mesenteric lymph nodes.Peptides 9, 257–267.

    Article  PubMed  CAS  Google Scholar 

  • Quirion, R., Dam, T. V., and Guard, S. (1991) Selective neurokinin receptor radioligands.Ann. NY Acad. Sci. 632, 137–144.

    Article  PubMed  CAS  Google Scholar 

  • Quirion, R., Shults, C. W., Moody, T. W., Pert, C. B., Chase, T. N., and O’Donohue, T. L. (1983) Autoradiographic distribution of substance P receptors in rat central nervous system.Nature 303, 714–716.

    Article  PubMed  CAS  Google Scholar 

  • Rau, D. and Burcher, E. (1992) Autoradiographic binding sites for tachykinins and calcitonin gene-related peptide in rat urinary bladder: effect of capsaicin.Neuropeptides 22, 55 (abstract).

    Article  Google Scholar 

  • Regoli, D., Drapeau, G., Dion, S., and Couture, R. (1988) New selective agonists for neurokinin receptors: pharmacological tools for receptor characterization.Trends Pharmacol. Sci. 9, 290–295.

    Article  PubMed  CAS  Google Scholar 

  • Rothstein, R. D., Johnson, E., and Ouyang, A. (1989) Substance P: mechanism of action and receptor distribution at the feline ileocecal spincter region. Am.J. Physiol. 257, G447–G453.

    PubMed  CAS  Google Scholar 

  • Rothstein, R. D., Johnson, E., and Ouyang, A. (1991) Distribution and density of substance P receptors in the feline gastrointestinal tract using autoradiography.Gastronterology 100, 1676–1581.

    Google Scholar 

  • Sann, H., Rossler, W., Hammer, K., and Pierau, F.-K. (1992) Substance P and calcitonin gene-related peptide in the ureter of chicken and guinea pig: distribution, binding sites and possible functions.Neuroscience 49, 699–713.

    Article  PubMed  CAS  Google Scholar 

  • Saria, A., Lundberg, J. M., Hua, X., and Lembeck, F. (1983) Capsaicininduced substance P release and sensory control of vascular permeability in the guinea pig ureter.Neurosci. Lett. 41, 167–172.

    Article  PubMed  CAS  Google Scholar 

  • Shigematsu, K., Saavedra, J. M., and Kurihara, M. (1986) Specific substance P binding sites in rat thymus and spleen: in vitro autoradiographic study.Regul. Pept. 16, 147–156.

    Article  PubMed  CAS  Google Scholar 

  • Stephenson, J. A. (1988Receptor localization in the cardiovascular system.MSc thesis, University of Melbourne, Australia.

    Google Scholar 

  • Stephenson, J. A., Burcher, E., and Summers, R. J. (1986) Autoradioraphic demonstration of endothelium-dependent binding of [125I]-Bolton-Hunter substance P to dog carotid artery.Eur. J. Pharmacol. 124, 377–378.

    Article  PubMed  CAS  Google Scholar 

  • Stephenson, J. A., Summers, R. J., and Burcher, E. (1987a) Endothelial-dependent binding of [125I]-Bolton-Hunter substance P in blood vessels, inSubstance P and NeurokininsHenry, J. L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., and Regoli, D., eds.), Springer-Verlag, New York, pp. 53–55.

    Google Scholar 

  • Stephenson, J. A., Summers, R. J., and Burcher, E. (1987b) Autoradiographic localization and characterization of substance P binding in dog kidney.Eur. J. Pharmacol. 142, 391–402.

    Article  CAS  Google Scholar 

  • Strigas, J. and Burcher, E. (1993) Autoradiographic localization of tachykinin binding sites in guinea-pig and human airways, using selective radioligands.Clin. Exp. Pharmacol. Physiol.suppl. 1, 705 (abstract).

    Google Scholar 

  • Too, H.-P., Cordova, J. L., and Maggio, J. E. (1989) A novel radioimmunoassay for neuromedin K. I. Absence of neuromedin K-like immunoreactivity in guinea pig ileum and bladder. II. Heterogeneity of tachykinins in guinea pig tissues.Reg. Pept. 26, 93–105.

    Article  CAS  Google Scholar 

  • Vigna, S. R., Mantyh, C. R., Soll, A. H., Maggio, J. E., and Mantyh, P. W. (1989) Substance P receptors on canine chief cells: localization, characterization and function.J. Neuroscience 31, 757–770.

    Article  Google Scholar 

  • Von Euler, U. and Hedqvist, P. (1974) Effect of substance P on the response of guinea pig vas deferens to transmural nerve stimulation.Acta Physiol. Scand. 90, 651–653.

    Article  Google Scholar 

  • Walsh, D. A., Mapp, P. I., Wharton, J., Rutherford, R. A. V., Kidd, B. L., Revell, P. A., Blake, D. R., and Polak, J. M. (1992) Localization and characterization of substance P binding to human synovial tissue in rheumatoid arthritis.Ann. Rheum. Dis. 51, 313–317.

    Article  PubMed  CAS  Google Scholar 

  • Watkins, D. J. and Burcher, E. (1987) Autoradiographic localization of substance (SP) binding sites in guinea pig respiratory tract, inSubstance P and NeurokininsHenry, J. L., Couture, R., Cuello, A. C., Pelletier, G., Quirion, R., and Regoli, D., eds.), Springer-Verlag, New York, pp. 87–89.

    Google Scholar 

  • Wiedermann C. J., Sertil, K., and Pert, C. B. High-affinity substance P binding sites in rat esophagus plexus submucosus.Am. J. Physiol. 253, R167–171.

    Google Scholar 

  • Xiao, X.-H., Mussap, C. J., and Burcher, E. (1992) Characterization of the tachykinin NK2 receptor subtype in the rabbit pulmonary artery.Peptides 13, 281–285.

    Article  PubMed  CAS  Google Scholar 

  • Zeng, X.-P., Lavielle, S., and Burcher, E. (1993) Evidence for tachykinin N-2 receptors in guinea pig airways from binding and functional studies, using a new selective radioligand, [125I]-[Lys5,Tyr(12)7,MeLeu9,Nle’0-NKA(4–10).Neuropeptidesin press).

    Google Scholar 

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Authors
  1. Elizabeth Burcher
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  2. Christian J. Mussap
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  3. Jennifer A. Stephenson
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Editor information

Editors and Affiliations

  1. Biopharm Consultists, Tucson, AZ, USA

    Stephen H. Buck

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© 1994 Springer Science+Business Media New York

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Burcher, E., Mussap, C.J., Stephenson, J.A. (1994). Autoradiographic Localization of Receptors in Peripheral Tissues. In: Buck, S.H. (eds) The Tachykinin Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0301-8_6

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  • DOI: https://doi.org/10.1007/978-1-4612-0301-8_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6699-0

  • Online ISBN: 978-1-4612-0301-8

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