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Role of Receptors in Nociception

  • Chapter
The Tachykinin Receptors

Part of the book series: The Receptors ((REC))

Abstract

Nociception depends on the synaptic transmission of action potentials generated in high threshold sensory afferent fibers within the peripheral tissues, into the dorsal horn of the spinal cord and, thereafter, up the neuroaxis to the level of consciousness where, in humans, the sensation of pain is experienced. Those sensory fibers involved in nociception are primarily the smaller, unmyelinated ones, although it is clear that the smallest unmyelinated (AS) fibers also contribute and even A(• fibers may be involved in nociceptive responses under particular circumstances (Hill, 1986; Cervero and Laird,1991; Handwerker and Kobal, 1993). The unmyelinated fibers are of greatest interest in the present context as these are the ones that contain substance P (SP) and other peptides as part of their transmitter complement (Salt and Hill, 1983; Duggan and Weihe, 1991). Sensory nerve fibers are pseudounipolar, and peptides synthesized in dorsal root ganglion neurons are transported both centrally and peripherally and can be released from terminals within the dorsal horn of the spinal cord and/or within peripheral tissues (Fig.1 ;Hill, 1986; Salt and Hill, 1983).

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Authors
  1. Raymond G. Hill
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  1. Biopharm Consultists, Tucson, AZ, USA

    Stephen H. Buck

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© 1994 Springer Science+Business Media New York

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Hill, R.G. (1994). Role of Receptors in Nociception. In: Buck, S.H. (eds) The Tachykinin Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0301-8_15

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  • DOI: https://doi.org/10.1007/978-1-4612-0301-8_15

  • Publisher Name: Humana Press, Totowa, NJ

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