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Gender Differences in Biological Markers of Alcohol Use

  • Chapter
Addictive Behaviors in Women

Part of the book series: Drug and Alcohol Abuse Reviews ((DAAR,volume 5))

Abstract

In spite of the fact that much of the research data gathered on alcohol use and alcoholism has been elicited from a male population, it is clear that there are gender differences associated with almost all dimensions of human alcohol consumption. As more research is undertaken with female participants, examples of alcohol-related gender differences become more numerous and clear cut. For instance, there are indications that female alcoholics are more likely than male alcoholics to be polydrug users, displaying a preference for prescription CNS depressants1.As well, women have higher blood-alcohol levels and a lower volume of distribution (Vd) of alcohol than do males after an equivalent amount of acute alcohol consumption, a difference thought by some investigators to be attributable to the relatively higher levels of body fat in women;2or as other researchers assert, the result of a decreased first-pass metabolism by gastric alcohol dehydrogenase.3It also appears that there are differences in the effects of alcohol on both the morphological features4and cognitive functions5of the brain. It was noted some time ago that females seemed to suffer greater liver damage over a shorter period of drinking history than males.6,7This temporal foreshortening effect (referred to as telescoping) has not only been associated with severity of liver damage, but apparently applies to most of the adverse consequences

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  1. Linda S. LaGrange
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    Ronald R. Watson

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LaGrange, L.S. (1994). Gender Differences in Biological Markers of Alcohol Use. In: Watson, R.R. (eds) Addictive Behaviors in Women. Drug and Alcohol Abuse Reviews, vol 5. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0299-8_5

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