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Alcohol and Hormones pp 21–47Cite as

Opioid-Mediated Control of Neuroendocrine Function

Roie of к,μ and ε Receptors

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Part of the book series: Drug and Alcohol Abuse Reviews ((DAAR,volume 6))

Abstract

The purpose of this chapter is to discuss the historical perspectives, current state of the literature, and suggested new strategies for the identification of the opioid receptors involved in the control of neuroendocrine function. As will become apparent, there is a vast body of data on the neuroendocrine effects of various opiate agonists and antagonists, and the involvement of endogenous opioid peptides (EOPs*) in neuroendocrine function, but an extensive literature review suggests that we know only one factor for certain: Exogenous and endogenous opioids exert pronounced effects on endocrine function, and EOPs may be intimately involved in the physiological regulation of endocrine function. However, we cannot definitively draw conclusions as to which EOPs are involved in these effects or the opioid receptor subtype that mediates these effects. The reasons for this conclusion will be discussed fully below, but it seems clear that, after intense study for nearly two decades, we can only conclude that compounds with some selectivity for x and.t receptors influence neuroendocrine function. Also, we are still uncertain whether one or both receptors are involved

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Authors
  1. Theodore J. Cicero
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  2. Michael L. Adams
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Editors and Affiliations

  1. University of Arizona, Tucson, Arizona, USA

    Ronald R. Watson

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© 1995 Springer Science+Business Media New York

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Cicero, T.J., Adams, M.L. (1995). Opioid-Mediated Control of Neuroendocrine Function. In: Watson, R.R. (eds) Alcohol and Hormones. Drug and Alcohol Abuse Reviews, vol 6. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0243-1_2

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  • DOI: https://doi.org/10.1007/978-1-4612-0243-1_2

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6678-5

  • Online ISBN: 978-1-4612-0243-1

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