Abstract
Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease. To study the immune responses leading to the breakdown of tolerance to islet β-cells, genes of putative causative agents and of major histocompatibility complex (MHC) are linked to insulin promoter and incorporated into the germ line of a mouse. The expression of transgenes are tissue specific (β-cell-specific) and their actions are analyzed during the life span of the “host” animals. These transgenic mice not only serve as models of IDDM but also provide new powerful tools for studying the many aspects of peripheral tolerance.
Keywords
- Transgenic Mouse
- Major Histocompatibility Complex
- Major Histocompatibility Complex Class
- Major Histocompatibility Complex Molecule
- Peripheral Tolerance
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Gu, D., Sarvetnick, N. (1994). Murine Transgenic Models of IDDM. In: Draznin, B., LeRoith, D. (eds) Molecular Biology of Diabetes. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0241-7_2
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DOI: https://doi.org/10.1007/978-1-4612-0241-7_2
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4612-6677-8
Online ISBN: 978-1-4612-0241-7
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