Murine Transgenic Models of IDDM

  • Danling Gu
  • Nora Sarvetnick


Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease. To study the immune responses leading to the breakdown of tolerance to islet β-cells, genes of putative causative agents and of major histocompatibility complex (MHC) are linked to insulin promoter and incorporated into the germ line of a mouse. The expression of transgenes are tissue specific (β-cell-specific) and their actions are analyzed during the life span of the “host” animals. These transgenic mice not only serve as models of IDDM but also provide new powerful tools for studying the many aspects of peripheral tolerance.


Transgenic Mouse Major Histocompatibility Complex Major Histocompatibility Complex Class Major Histocompatibility Complex Molecule Peripheral Tolerance 
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© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Danling Gu
  • Nora Sarvetnick

There are no affiliations available

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