Abstract
The secretion of insulin is closely regulated in vivo in order to maintain the plasma glucose concentration in a narrow range despite long periods of fasting and intermittent food intake. The regulation of insulin secretion has been studied extensively and involves a complex interaction of glucose and other nutrients, and endocrine, paracrine, and neurohumoral factors. The effects of these factors on insulin secretion are transduced by their interaction with specific receptor molecules on the surface of the β-cell. The physiologic role of many of these ligand-receptor interactions in altering insulin secretion has been clarified recently and their distal signaling mechanisms characterized.
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References
Rajan AS, Aguilar-Bryan L, Nelson DA, Yaney GC, Hsu WH, Kunze DL, et al.: Ion channels and insulin secretion. Diabetes Care 13:340–363, 1990.
Boyd AE, Aguilar-Bryan L, Bryan J, Kunze D, Moss LG, Nelson DA, et al.: Sulfonylurea signal transduction. Rec Prog Horm Res 47:299–317, 1991.
Aguilar-Bryan L, Nichols C, Rajan A, Parker C, Bryan J: Co-expression of Sulfonylurea receptors and KATP channels in hamster insulinoma tumor (HIT) cells. J Biol Chem 267:14, 934-14, 940, 1992.
Maletti M, Portha B, Carlquist M, Kergoat M, Laburthe M, Marie J, et al.: Evidence for and characterization of specific high affinity binding sites for the gastric inhibitory polypeptide in pancreatic β cells. Endocrinology 115:1324–1331, 1984.
Goke R, Cole T, Conlon J: Characterization of the receptor for glucagon-like peptide-l(7–37)amide on plasma membranes from rat insulinoma-derived cells by covalent cross-linking. J Mol Endocrinol 2:93–98, 1989.
Dillon JS, Tanizawa T, Wheeler MB, Leng X-H, Ligon BB, Rabin DU, et al.: Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor. Endocrinology 133:1907–1916, 1993.
Thorens B: 1992 Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci USA 89:8641–8645.
Lu M, Wheeler M, Leng X-H, Boyd AE: The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide 1(7–37). Endocrinology 132:94–100, 1993.
Drucker DJ, Philippe J, Mojsov S, Chick WL, Habener JF: Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci USA 84:3434–3438, 1987.
Wheeler M, Lu M, Dillon J, Leng X-H, Chen C, Boyd AE: Functional expression of the glucagon-like peptide-1(7–37) receptor: evidence for coupling to phospholipase C as well as adenylyl cyclase. Endocrinology 133:57–62, 1993.
Lu M: Signal transduction of the endogenous and recombinant glucagon-like peptide 1(7–37) receptor. Baylor College of Medicine: PhD Thesis in Cell Biology, 1993.
Fehmann HC, Habener JF: Insulinotropic hormone glucagon-like peptide-1(7–37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology 130:159–166, 1992.
Jelinek LJ Lok, S., Rosenberg, G.B., Smith, R.A., Grant, F.J., Biggs, S., et al.: Expression cloning and signaling properties of the rat glucagon receptor. Science 259:1614–1616, 1993.
Amatruda T, Gerard N, Gerard C, Simon M: Specific interactions of chemoattractant factor receptors with G-proteins. J Biol Chem 14:10, 139-10, 144, 1993.
Wolf B, Florholmen J, Turk J, McDaniel M: Studies of the calcium requirement for glucose and carbachol induced augmentation of inositol trisphosphate and inositol tetrakisphosphate accumulation in digitonin per-meabilized islets. J Biol Chem 263:3565–3575, 1988.
Zawalich W: Modulation of insulin secretion from β cells by phosphoinositide derived second messenger molecules. Diabetes 37:137–141, 1988.
Lu M, Soltoff S, Yaney G, Boyd AE: The mechanisms underlying the glucose dependence of arginine vasopressin induced insulin secretion in β cells. Endocrinology 132:2141–2148, 1993.
Metz S: Is protein kinase C required for physiologic insulin release. Diabetes 37:3–7, 1987.
Li G, Pralong W, Pittet D, Mayr G, Schlegel W, Wollheim C: Inositol tetrakisphosphate isomers and elevation of cytosolic Ca2+ in vasopressin-stimulated insulin-secreting RlNm5F cells. J Biol Chem 267:4349–4356, 1992.
Martin S, Yule D, Dunne M, Gallacher D, Petersen O: Vasopressin directly closes ATP sensitive potassium channels evoking membrane depolarization and an increase in the free intracellular calcium concentration in insulin secreting cells. EMBO J 8:3595–3599, 1989.
Miralies P, Peiro E, Silvestre RA, Villanueva ML, Marco J: Effects of galanin on islet cell secretory responses to VIP, GIP, 8-CCK, and glucagon by the perfused rat pancreas. Met Clin Exp 37:766–770, 1988.
Tajiri Y, Sako Y, Umeda F, Hisatomi A, Nawata H: Effect of galanin on arginine-stimulated pancreatic hormone release from isolated perifused rat islets. Horm Metab Res 22:1–6, 1990.
Fehmann HC, Habener JF: Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7–37) in mouse insulinoma beta TC-1 cells. Endocrinology 130:2890–2896, 1992.
Greenberg GR, McDonald TJ: Effect of galanin and vagal integrity on insulin release in dogs. Pancreas 3:122–127, 1988.
Lindskog S, Ahren B: Effects of galanin on insulin and glucagon secretion in the rat. Int J Pancreatol 4:335–344, 1989.
Lindskog S, Ahren B: Galanin and pancreastatin inhibit stimulated insulin secretion in the mouse: comparison of effects. Horm Res 29:237–240, 1988.
Yoshimura T, Ishizuka J, Greeley GJ, Thompson JC: Effect of galanin on glucose-, arginine-, or potassium-stimulated insulin release. Am J Physiol 256:E619–E623, 1989.
Ahren B, Ar’Rajab A, Bottcher G, Sundler F, Dunning BE: Presence of galanin in human pancreatic nerves and inhibition of insulin secretion from isolated human islets. Cell Tis Res 264:263–267, 1991.
McKnight GL, Karlsen AE, Kowalyk S, Mathewes SL, Sheppard PO, O’Hara PJ, et al.: Sequence of human galanin and its inhibition of glucose-stimulated insulin secretion from RIN cells. Diabetes 41:82–87, 1992.
Lagny PI, Amiranoff B, Lorinet AM, Tatemoto K, Laburthe M: Characterization of galanin receptors in the insulin-secreting cell line Rin m 5F: evidence for coupling with a pertussis toxin-sensitive guanosine triphosphate regulatory protein. Endocrinology 124:2635–2641, 1989.
Amiranoff B, Servin AL, Rouyer FC, Couvineau A, Tatemoto K, Laburthe M: Galanin receptors in a hamster pancreatic beta-cell tumor: identification and molecular characterization. Endocrinology 121:284–289, 1987.
Sharp GW, Le M, Brustel Y, Yada T, Russo LL, Bliss CR, et al.: Galanin can inhibit insulin release by a mechanism other than membrane hyper-polarization or inhibition of adenylate cyclase. J Biol Chem 264:7302–7309, 1989.
Amiranoff B, Lorinet AM, Laburthe M: Galanin receptor in the rat pancreatic beta cell line Rin m 5F. Molecular characterization by chemical cross-linking. J Biol Chem 264:20, 714-20, 717, 1989.
deWeille J, Schmid AH, Fosset M, Lazdunski M: ATP-sensitive K+ channels that are blocked by hypoglycemia-inducing sulfonylureas in insulin-secreting cells are activated by galanin, a hyperglycemia-inducing hormone. Proc Natl Acad Sci USA 85:1312–1316, 1988.
Drews G, Debuyser A, Nenquin M, Henquin JC: Galanin and epinephrine act on distinct receptors to inhibit insulin release by the same mechanisms including an increase in K+ permeability of the B-cell membrane. Endocrinology 126:1646–1653, 1990.
Ahren B, Arkhammar P, Berggren PO, Nilsson T: Galanin inhibits glucose-stimulated insulin release by a mechanism involving hyperpolarization and lowering of cytoplasmic free Ca2+ concentration. Biochem Biophy Res Commun 140:1059–1063, 1986.
Homaidan FR, Sharp GW, Nowak LM: Galanin inhibits a dihydropyridine-sensitive Ca2+ current in the RINm5f cell line. Proc Natl Acad Sci USA 88:8744–8748, 1991.
Hsu W, Xiang H, Rajan A, Boyd AE: Activation of alpha 2 adrenergic receptors decreases calcium influx to inhibit insulin secretion in a hamster β cell line: an action mediated by guanosine triphosphate binding protein. Endocrinology 128:958–964, 1991.
Hsu W, Xiang H, Rajan A, Kunze D, Boyd AE: Somatostatin inhibits insulin secretion by a G-protein mediated decrease in Ca2+ entry through voltage dependent Ca2+ channels in the beta cell. J Biol Chem 266:837–843, 1991.
Amiranoff B, Lorinet AM, Lagny PI, Laburthe M: Mechanism of galanin-inhibited insulin release. Occurrence of a pertussis-toxin-sensitive inhibition of adenylate cyclase. Eur J Biochem 177:147–152, 1988.
Philippe J, Missotten M: Functional characterization of acAMP-responsive element of the rat insulin I gene. J Biol Chem 265:1465–1469, 1990.
Osterrieder W, Brum A, Hescheler J, Trautwein W: Injection of subunits of cAMP-dependent protein kinase into cardiac myocytes modulates calcium current. Nature 298:576–578, 1982.
Ullrich S, Wollheim CB: Galanin inhibits insulin secretion by direct interference with exocytosis. FEBS Lett 247:401–404, 1989.
Robertson RP, Seaquist ER, Walseth TF: G proteins and modulation of insulin secretion. Diabetes 40:1–6, 1991.
Nilsson T, Arkhammar P, Rorsman P, Berggren PO: Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration. J Biol Chem 264:973–980, 1989.
Rokaeus A: Galanin: a newly isolated biologically active neuropeptide. Trends Neurosci 10:158–164, 1987.
Cormont M, Le M, Brustel Y, Van OE, Spiegel AM, Sharp GW: Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptor. Diabetes 40:1170–1176, 1991.
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Dillon, J.S., Lu, M., Wheeler, M.B., Boyd, A.E. (1994). β-Cell Receptors. In: Draznin, B., LeRoith, D. (eds) Molecular Biology of Diabetes. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0241-7_12
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DOI: https://doi.org/10.1007/978-1-4612-0241-7_12
Publisher Name: Humana Press, Totowa, NJ
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