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The Endothelin Peptides

Roles in Physiology and Pathophysiology

  • Chapter
Endocrinology of the Vasculature

Part of the book series: Contemporary Endocrinology ((COE,volume 1))

Abstract

Yanagisawa and colleagues (1) isolated a long sought endogenous vasoconstricting peptide family, in part from endothelial cells: This peptide family was named the endothelins (ET). Endothelin-1 (ET-1), ET-2, and ET-3 comprise those peptides produced in a variety of tissues, where they act as modulators of important cell processes. These peptides act through binding to two well-defined classes of transmembrane receptors, ETAand ETBwhere the stimulation of several signaling pathways leads to their mitogenic, vasoconstricting, and developmental actions. In this chapter, the details of ET synthesis and regulation and action and defined physiologic and pathophysiologic roles are examined In particular, there is an emphasis on defining the roles of ET-1 as an important vascular hormone.

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  1. Ellis R. Levin MD
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  1. School of Medicine, Wayne State University, Detroit, Michigan, USA

    James R. Sowers MD

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Levin, E.R. (1996). The Endothelin Peptides. In: Sowers, J.R. (eds) Endocrinology of the Vasculature. Contemporary Endocrinology, vol 1. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0231-8_4

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  • DOI: https://doi.org/10.1007/978-1-4612-0231-8_4

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