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Ionic Mechanisms of Peptide-Induced Responses in Vascular Endothelial Cells

  • Chapter
Endocrinology of the Vasculature

Part of the book series: Contemporary Endocrinology ((COE,volume 1))

Abstract

The single layer of endothelial cells (ECs) that lines the luminal side of blood vessels plays an important role in regulating blood vessel function. Underlying the EC layer are several layers of vascular smooth muscle cells (VSMC) (Fig. 1). Although the EC layer serves in part as a protective covering and permeability barrier to the movement of substances through the blood vessel wall, ECs also have an active role in mediating the effect of hormonal and locally produced substances that regulate VSMC tension and growth. There is evidence that relaxation or decreases in blood vessel contractility caused by steroid hormones (1), acetyl choline(2 3)and various peptides (described in Peptides and Vascular Responses) are mediated by the EC layer and do not occur in blood vessels in which the endothelial cell layer has been removed. There is a large body of evidence that shows that ECs release substances that cause blood vessels to dilate(2-5). A major component of these endothelium-derived relaxing factors is nitric oxide (NO), the syn

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Authors
  1. Jianben Song PhD
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  2. Jeffrey L. Ram PhD
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Editors and Affiliations

  1. School of Medicine, Wayne State University, Detroit, Michigan, USA

    James R. Sowers MD

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© 1996 Springer Science+Business Media New York

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Song, J., Ram, J.L. (1996). Ionic Mechanisms of Peptide-Induced Responses in Vascular Endothelial Cells. In: Sowers, J.R. (eds) Endocrinology of the Vasculature. Contemporary Endocrinology, vol 1. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0231-8_2

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  • DOI: https://doi.org/10.1007/978-1-4612-0231-8_2

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6672-3

  • Online ISBN: 978-1-4612-0231-8

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