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Endocrinology of the Vasculature pp 205–214Cite as

The Vascular Renin System

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Part of the book series: Contemporary Endocrinology ((COE,volume 1))

Abstract

In the classical endocrine renin—angiotensin system (RAS), renin secreted from the kidney cleaves hepatic angiotensinogen in the circulation to launch a cascade of angiotensin peptides including angiotensin (A) I, II, and III. AII, the most prominent of these peptide hormones, initiates through specific plasma membrane receptors, a host of physiological actions ranging from vasoconstriction to volume and growth regulation (1-4). Circulating plasma levels of renin and/or AII do not always correlate with their purported functions (5, 6),because of inaccuracies of renin and/or AII measurements, or not considering the sodium status (7). Studies with angiotensin-converting enzyme (ACE) inhibitors, and more recently with specific AII receptor antagonists, have demonstrated that even when the circulating levels are low, AII remains a major regulator of many biological responses, including blood pressure (8).

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Authors
  1. Peter Eggena PhD
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  2. Jack D. Barrett PhD
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Editors and Affiliations

  1. School of Medicine, Wayne State University, Detroit, Michigan, USA

    James R. Sowers MD

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Eggena, P., Barrett, J.D. (1996). The Vascular Renin System. In: Sowers, J.R. (eds) Endocrinology of the Vasculature. Contemporary Endocrinology, vol 1. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0231-8_15

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  • DOI: https://doi.org/10.1007/978-1-4612-0231-8_15

  • Publisher Name: Humana Press, Totowa, NJ

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