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Osteoporosis pp 251–269Cite as

Therapy for Osteoporosis in Men

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Part of the book series: Current Clinical Practice ((CCP))

Abstract

A 63-yr-old man experienced acute, severe back pain while digging in the garden. He was seen in the Emergency Department, and found to have a new anterior compression fracture of T-11. Although his back pain had been somewhat relieved by analgesics, he was still, 3 wk later, in some pain and unable to be active. He had suffered a fracture of his humerus 2 yr before during a fall on an icy sidewalk.

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References

  1. Nguyen T, Sambrook P, Kelly P, Jones G, Lord SJ. Prediction of osteoporotic fractures by postural instability and bone density.BMJ1993; 307: 1111–1115.

    Article  PubMed  CAS  Google Scholar 

  2. Grisso JA, Chiu GY, Maislin G, Steinmann WC, Portale J. Risk factors for hip fractures in men: a preliminary study..1 Bone Miner Res1991; 6: 865–868.

    Article  CAS  Google Scholar 

  3. Ray WA, Griffin MR, Schaffner W, Baugh DK, Melton LJ III. Psychotropic drug use and the risk of hip fracture.N Engl J Med1987; 316: 363–370.

    Article  PubMed  CAS  Google Scholar 

  4. Ray WA, Griffin MR, Downey W. Benzodiazepines of long and short elimination half-life and the risk of hip fracture.JAMA1989; 262: 3303–3307.

    Article  PubMed  CAS  Google Scholar 

  5. Karlsson MK, Johnell O, Nilsson BE, Sembo I, Obrant KJ. Bone mineral mass in hip fracture patients.Bone1993; 14: 161–165.

    Article  PubMed  CAS  Google Scholar 

  6. Fiatarone MA, O’Neill E, Ryan ND, Clements KM, Solares GR, Nelson ME, Roberts SB, Keyhayias JJ, Lipsitz LA, Evans WJ. Exercise training and nutritional supplementation for physical frailty in very elderly people.N Engl JMed1994; 330: 1769–1775.

    Article  CAS  Google Scholar 

  7. Tinetti ME, Baker DI, McAvay G, Claus EB, Garrett P, Gottschalk M, Koch ML, Trainor K, Horwitz RI. A multifactorial intervention to reduce the risk of galling among elderly people living in the community. NEngl JMed1994; 331: 821–827.

    Article  CAS  Google Scholar 

  8. Aaron JE, Makins NB, Sagreiya K. The microanatomy of trabecular bone loss in normal aging men and women.Clin Orthop Related Res1987; 215: 260–271.

    Google Scholar 

  9. Eriksen EF. Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease.Endocr Rev1986; 7: 379–408.

    Article  PubMed  CAS  Google Scholar 

  10. Eriksen EF, Mosekilde L, Melsen F. Trabecular bone resorption depth decreases with age: differences between normal males and females.Bone1985; 6: 141–146.

    Article  PubMed  CAS  Google Scholar 

  11. Croucher PI, Mellish RWE, Vedi S, Garrahan NJ, Compston JE. The relationship between resorption depth and mean interstitial bone thickness: age-related changes in man.Calcif Tissue Int1989; 45: 15–19.

    Article  PubMed  CAS  Google Scholar 

  12. Melsen F, Melsen B, Mosekilde L, Bergmann S Histomorphometric analysis of normal bone from the iliac crest.Acta Pathol Microbiol Scand1986; 86: 70–81.

    Google Scholar 

  13. Kragstrup J, Melsen F, Mosekilde L. Thickness of bone formed at remodeling sites in normal human iliac trabecular bone: variations with age and sex.Metab Bone Dis and Related Res1983; 5: 17–21.

    Article  Google Scholar 

  14. Seeman E, Melton LJ III. Risk factors for spinal osteoporosis in men.Am JMed1983; 75: 977–983.

    CAS  Google Scholar 

  15. Parfitt AM, Duncan H. Metabolic bone disease affecting the spine. In: Rothman R, ed.The Spine2nd ed. Philadelphia, PA: Saunders, 1982; pp. 775–905.

    Google Scholar 

  16. Resch H, Pietschmann P, Woloszczuk W, Krexner E, Bernecker P, Willvonseder R. Bone mass and biochemical parameters of bone metabolism in men with spinal osteoporosis.EurJ Clin Invest1992; 22: 542–545.

    Article  CAS  Google Scholar 

  17. Kelepouris N, Harper KD, Gannon F, Kaplan FS, Haddad JG. Severe osteoporosis in men.Ann Int Med1995; 123: 452–460.

    PubMed  CAS  Google Scholar 

  18. Riggs BL, Melton LJ. Medical progress: involutional osteoporosis.NEng1 JMed1986; 314: 1676–1686.

    Article  CAS  Google Scholar 

  19. Francis RM, Peacock M, Marshall DH, Horsman A, Aaron JE. Spinal osteoporosis in men.Bone Miner1989; 5: 347–357.

    Article  PubMed  CAS  Google Scholar 

  20. DeVemejoul MC, Bielakoff J, Herve M. Evidence for defective osteoblastic function. A role for alcohol and tobacco consumption in osteoporosis in middle-aged men.Clin Orthop1983; 179: 107–115.

    Google Scholar 

  21. Hills E, Dunstan CR, Wong SYP, Evans RA. Bone histology in young adult osteoporosis.J Clin Pathol1989; 42: 391–397.

    Article  PubMed  CAS  Google Scholar 

  22. Marie PJ, de Vernejoul MC, Donnes D, Hott M. Decreased DNA synthesis by culture osteoblastic cells in eugonadal osteoporotic men with defective bone formation.J Clin Invest1991; 88: 1167–1172.

    Article  PubMed  CAS  Google Scholar 

  23. Nordin BEC, Aaron J, Speed R, Francis RM, Makins N. Bone formation and resorption as the determinants of trabecular bone volume in normal and osteoporotic men.Scott Med J 1984;29: 171–175.

    PubMed  CAS  Google Scholar 

  24. Jackson JA, Kleerekoper M. Osteoporosis in men: diagnosis, pathophysiology, and prevention.Medicine1990; 69: 137–152.

    Article  PubMed  CAS  Google Scholar 

  25. Jones G, Nguyen T, Sambrook P, Kelly PJ, Eisman JA. Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology study.Br Med J1994; 309: 691–695.

    Article  CAS  Google Scholar 

  26. Garn SM, Sullivan TV, Decker SA, Larkin FA, Hawthorne VM. Continuing bone expansion and increasing bone loss over a two-decade period in men and women from a total community sample.Am J Human Biol1992; 4: 57–67.

    Article  Google Scholar 

  27. Orwoll ES, Oviatt SK, McClung MR, Deftos LJ, Sexton G. The rate of bone mineral loss in normal men and the effects of calcium and cholecalciferol supplementation.Ann Int Med1990; 112: 29–34.

    PubMed  CAS  Google Scholar 

  28. Mazess RB, Barden HS, Drinka PJ, Bauwens SF, Orwoll ES, Bell NH. Influence of age and body weight on spine and femur bone mineral density in U.S. white men.JBone Miner Res1990; 5: 645–652.

    Article  CAS  Google Scholar 

  29. Tobin JD, Fox KM, Cejku ML. Bone density changes in normal men: a 4–19 year longitudinal study.J Bone Miner Res1993; 8: 102.

    Google Scholar 

  30. Gotfredsen A, Hadberg A, Nilas L, Christiansen C. Total body bone mineral in healthy adults.JLab Clin Med1987; 110: 362–368.

    CAS  Google Scholar 

  31. Hannan MT, Felson DT, Anderson JJ. Bone mineral density in elderly men and women: results from the Framingham osteoporosis study.J Bone Miner Res1992; 7: 547–553.

    Article  PubMed  CAS  Google Scholar 

  32. Davis JW, Ross PD, Vogel JM, Wasnich RD. Age-related changes in bone mass among Japanese-American men.Bone Miner1991; 15: 227–236.

    Article  PubMed  CAS  Google Scholar 

  33. Meier DE, Orwoll ES, Jones JM. Marked disparity between trabecular and cortical bone loss with age in healthy men: measurement by vertebral computed tomography and radioal photon absorptiometry.Ann Intern Med1984; 101: 605–612.

    PubMed  CAS  Google Scholar 

  34. Mann T, Oviatt SK, Wilson D, Nelson D, Orwoll ES. Vertebral deformity in men.JBone Miner Res1992; 7(11): 1259–1265.

    Article  CAS  Google Scholar 

  35. Looker AC, Harris TB, Madans JH, Sempos CT. Dietary calcium and hip fracture risk: the NHANES I epidemiologic follow-up study.Osteoporosis Int1993; 3: 177–184.

    Article  CAS  Google Scholar 

  36. Snow-Harter C, Whalen R, Myburgh K, Arnaud S, Marcus R. Bone mineral density, muscle strength, and recreational exercise in men.J Bone Miner Res1992; 7: 1291–1296.

    Article  PubMed  CAS  Google Scholar 

  37. Colletti LA, Edwards J, Bordon L, Shary J, Bell NH. The effects of muscle-building exercise on bone mineral density of the radius, spine and hip in young men.Calcif Tissue Int1989; 45: 12–14.

    Article  PubMed  CAS  Google Scholar 

  38. Block JE, Genant HK, Black D. Greater vertebral bone mineral mass in exercising young men.West J Med1986; 145: 39–42.

    CAS  Google Scholar 

  39. Block JE, Friedlander AL, Brooks GA, Steiger P, Stubbs HA, Genant HK. Determinants of bone density among athletes engaged in weight-bearing and non-weight-bearing activity.J Appl Physiol1989; 67: 1100–1105.

    PubMed  CAS  Google Scholar 

  40. Jones HH, Priest JD, Hayes WC, Tichenor CC, Nagel DA. Humeral hypertrophy in response to exercise.J Bone Jt Surg1977; 59-A: 204–208.

    Google Scholar 

  41. Orwoll ES, Ferar J, Oviatt SK, McClung MR, Huntington K. The relationship of swimming exercise to bone mass in men and women.Arch Int Med1989; 149: 2197–2200.

    Article  CAS  Google Scholar 

  42. Need AG, Durbridge TC, Nordin BE. Anabolic steroids in postmenopausal osteoporosis.Wien Med Wochenschr1993; 143: 392–395.

    PubMed  CAS  Google Scholar 

  43. Bevier WC, Wiswell RA, Pyka G, Kozak KC, Newhall KM, Marcus R. Relationship of body composition, muscle strength, and aerobic capacity to bone mineral density in older men and women.J Bone Miner Res1989; 4: 421–432.

    Article  PubMed  CAS  Google Scholar 

  44. Myburgh KH, Zhou L-J, Steele CR, Arnaud S, Marcus R. In vivo assessment of forearm bone mass and ulnar bending stiffness in healthy men.J Bone Miner Res1992; 7: 1345–1350.

    Article  PubMed  CAS  Google Scholar 

  45. Frost HM. The role of changes in mechanical usage set points in the pathogenesis of osteoporosis.J Bone Miner Res1992; 7: 253–261.

    Article  PubMed  CAS  Google Scholar 

  46. Williams JA, Wagner J, Wasnich R, Heilbrun L. The effect of long-distance running upon appendicular bone mineral content.Med Sci Sports Exerc1984; 16: 223–227.

    PubMed  CAS  Google Scholar 

  47. Wickham CAC, Walsh K, Cooper C, Barker DJP, Margetts BM, Morris J, Bruce SA. Dietary calcium, physical activity, and risk of hip fracture: a prospective study.BMJ1989; 299: 889–892.

    Article  PubMed  CAS  Google Scholar 

  48. Paganini-Hill A, Chao A, Ross RK, Henderson BE. Exercise and other factors in the prevention of hip fracture: the Leisure World study.Epidemiology1991; 2: 16–25.

    Article  PubMed  CAS  Google Scholar 

  49. Larsson L, Sjodin B, Karlsson J. Histochemical and biochemical changes in human skeletal muscle with age in sedentary males, age 22–65 years.Acta Physiol Scand1978; 103: 31–39.

    Article  PubMed  CAS  Google Scholar 

  50. Aniansson A, Gustaffson E. Physical training in elderly men with special reference to quadriceps muscle strength and morphology.Clin Physiol1981; 1: 89–98.

    Article  Google Scholar 

  51. Rubenstein LZ, Josephson KR. Causes and prevention of falls in elderly people. In: Vellas B, Toupet M, Rubenstein L, Albarede JL, Christen Y, eds.Falls Balance and Gait Disorders in the Elderly. Paris: Elsevier, 1992, pp. 21–36.

    Google Scholar 

  52. Greendale GA, Barrett CE, Edelstein S, Ingles S, Haile R. Lifetime leisure exercise and osteoporosis.Am JEpidemiol1995; 141: 951–959.

    CAS  Google Scholar 

  53. American College of Medicine. ACSM position stand on osteoporosis and exercise.Med Sci Sports Exerc1995; 27: i-vii.

    Google Scholar 

  54. Young G, Marcus R, MinkoffJR, Kim LY, Segre GV. Age-related rise in parathyroid hormone in man: the use of intact and midmolecule antisera to distinguish hormone secretion from retention.J Bone Miner Res1987; 2: 367–374.

    Article  PubMed  CAS  Google Scholar 

  55. Endres DB, Morgan CH, Garry PJ, Omdahl JL. Age-related changes in serum immunoreactive parathyroid hormone and its biological action in healthy men and women.J Clin Endocrinol Metab 1987;65: 724–731.

    Article  PubMed  CAS  Google Scholar 

  56. Orwoll ES, Meier DE. Alterations in calcium, vitamin D, and parathyroid hormone physiology in normal men with aging: relationship to the development of senile osteopenia. JClin Endocrinol Metab1986; 63: 1262–1269.

    Article  CAS  Google Scholar 

  57. Slovik DM, Adams JS, Neer RM, Holick MF, Potts JR. Deficient production of I,25-dihydroxyvitamin D in elderly osteoporotic patients.NEngl JMed1981; 305: 372.

    Article  CAS  Google Scholar 

  58. Manolagas SC, Culler FL, Howard JE. The cytoreceptor assay for 1,25-dihydroxyvitamin D in elderly osteoporotic patients.J Clin Endocrinol Metab1983; 56: 751–760.

    Article  PubMed  CAS  Google Scholar 

  59. Epstein S, Bryce G, Hinman JW. The influence of age of bone mineral regulating hormones.Bone1986; 7: 421–425.

    Article  PubMed  CAS  Google Scholar 

  60. Halloran BP, Portale AA, Lonergan ET, Morris RCJ. Production and metabolic clearance of I,25-dihydroxyvitamin D in men: effect of advancing age.J Clin Endocrinol Metab1990; 70: 318–323.

    Article  PubMed  CAS  Google Scholar 

  61. Sherman SS, Tobin JD, Hollis BW, Gundberg CM, Roy TA, Plato CC. Biochemical parameters associated with low bone density in healthy men and women.J Bone Miner Res1992; 7: 1123–1130.

    Article  PubMed  CAS  Google Scholar 

  62. Kroger H, Laitinen K. Bone mineral density measured by dual-energy x-ray absorptiometry in normal men.Eur J Clin Invest1992; 22: 454–460.

    Article  PubMed  CAS  Google Scholar 

  63. Kelly PJ, Pocock NA, Sambrook PN, Eisman JA. Dietary calcium, sex hormones, and bone mineral density in men.Br Med J1990; 300: 1361–1364.

    Article  CAS  Google Scholar 

  64. Slemenda CW, Christian JC, Reed T, Reister TK, Williams CJ, Johnston CCJ. Long-term bone loss in men: effects of genetic and environmental factors.Ann Intern Med 1992;117: 286–291.

    PubMed  CAS  Google Scholar 

  65. Matkovic V, Kostial K, Simonovic I, Buzina R, Brodarec A, Nordin BEC. Bone status and fracture rates in two regions of Yugoslavia.Am JClin Nutr1979; 32: 540–549.

    CAS  Google Scholar 

  66. Lau E, Donnan S, Barker DJP, Cooper C. Physical activity and calcium intake in fracture of the proximal femur in Hong Kong.BMJ1988; 297: 1441–1443.

    Article  PubMed  CAS  Google Scholar 

  67. Cooper C, Barker DJ, Wickham C. Physical activity, muscle strength, and calcium intake in fracture of the proximal femur in Britain.BMJ1988; 297(6661): 1443–1446.

    Article  PubMed  CAS  Google Scholar 

  68. Holbrook TL, Barrett-Connor E, Wingard DL. Dietary calcium and risk of hip fracture: 14-year prospective population study.Lancet1988; II: 1046–1049.

    Article  Google Scholar 

  69. Nordin BEC, Marshall PH. Dietary requirements for calcium. In: Nordin BEC, ed.Calcium in Human Biology.New York: Springer-Verlag, 1988, pp. 447–471.

    Chapter  Google Scholar 

  70. O’Brien KO, Allen LH, Quatromoni P, Siu-Caldera M-L, Vieira NE, Perez A, Holick MF, Yergey AL. High fiber diets slow bone turnover in young men but have no effect on efficiency of intestinal calcium absorption. JNutr1993; 123: 2122–2128.

    PubMed  Google Scholar 

  71. Orwoll ES. The effects of dietary protein insufficiency and excess on skeletal health.Bone1992; 13: 343–350.

    Article  PubMed  CAS  Google Scholar 

  72. Heaney RP. Nutritional factors in bone health in elderly subjects: methodological and contextual problems.Am J Clin Nutr1989; 50: 1182–1189.

    PubMed  CAS  Google Scholar 

  73. Miller JZ, Smith DL, Flora L, Slemenda C, Jiang X, Johnston CCJ. Calcium absorption from calcium carbonate and a new form of calcium (CCM) in healthy male and female adolescents.Am J Clin Nutr1988; 48: 1291–1294.

    PubMed  CAS  Google Scholar 

  74. Curhan GC, Willett WC, Rimm EB, Stampfer MJ. A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones.NEngl JMed1993; 328: 833–838.

    Article  CAS  Google Scholar 

  75. Orwoll ES, Weigel RM, Oviatt SK, McClung MR, Deftos LJ. Calcium and cholecalciferol: effects of small supplements in normal men.Am J Clin Nutr1988; 48: 127–130.

    PubMed  CAS  Google Scholar 

  76. Agrawal R, Wallach S, Cohn S, Tessier M, Verch R, Hussain M, Zanzi I. Calcitonin treatment of osteoporosis. In: Pecile A, ed.Chemistry Physiology Pharmacology and Clinical Aspects. Exerpta Medica, Amsterdam, 1981; p. 237–246.

    Google Scholar 

  77. Burckhardt P, Bumand B. The effect of treatment with calcitonin on vertebral fracture rate in osteoporosis.Osteoporosis Int1993; 3: 24–30.

    Article  CAS  Google Scholar 

  78. McDermott MT, Kidd GS. The role of calcitonin in the development and treatment of osteoporosis.Endocr Rev1987; 8: 377–390.

    Article  PubMed  CAS  Google Scholar 

  79. Valkema R, Vismans F-JFE, Papapoulos SE, Pauwels EKJ, Bijvoet OLM. Maintained improvement in calcium balance and bone mineral content in patients with osteoporosis treated with the bisphosphonate APD.Bone Miner 1989;5: 183–192.

    Article  PubMed  CAS  Google Scholar 

  80. Reid IR, Alexander CJ, King AR, Ibbertson HK. Prevention of steroid-induced osteoporosis with (3-amino-l-hydroxypropylidene)-1, 1-bisphosphonate(APD).Lancet1988; January 23: 143–146.

    Article  Google Scholar 

  81. Papapoulos SE, Landman JO, Bijvoet OLM, Lowik CWGM, Valkema R, Pauwels EKJ, Vermeij P. The use of bisphosphonates in the treatment of osteoporosis.Bone1992; 13: S41–S49.

    Article  PubMed  CAS  Google Scholar 

  82. Morton DJ, Barrett-Connor EL, Edelstein SL. Thiazides and bone mineral density in elderly men and women.JBone Miner1993; 8: S265.

    Google Scholar 

  83. Wasnich R, Davis J, Ross P, Voger J. Effect of thiazide on rates of bone mineral loss: a longitudinal study.Br Med J 1990;301: 1303–1305.

    Article  CAS  Google Scholar 

  84. Ray WA, Griffin MR, Downey W, Melton LJI. Long-term use of thiazide diuretics and risk of hip fracture.Lancet1989; I: 687–690.

    Article  Google Scholar 

  85. Costanza LS, Weiner IM. On the hypocalciuric action of chlorothiazide.J Clin Invest1974; 54: 628–637.

    Article  Google Scholar 

  86. Song X, Wergedal JE. Hydrochlorothiazide stimulates proliferation of human osteoblasts in vitro.J Bone Miner Res1993; 8: S362.

    Google Scholar 

  87. Reeve J, Neunier PJ, Parsons JA, Bemat M, Bijvoet OLM, Courpron P, Edouard C, Klenerman L, Neer RM, Renier JC, Slovik D, Vismans FJFE, Potts JRJ. Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: a multicentre trial.Br Med J 1980;June 7: 1340–1344.

    Article  Google Scholar 

  88. Slovik DM, Rosenthal DI, Doppelt SH, Potts JRJ, Daly MA, Campbell JA, Neer RM. Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1–34) and 1,25dihydroxyvitamin D.J Bone Miner Res1986; 1: 377–381.

    Article  PubMed  CAS  Google Scholar 

  89. Reeve J, Bradbeer JN, Arlot M, Davies UM, Green JR, Hampton L, Edouard C, Hesp R, Hulme P, Ashby JP, Zanelli JM, Meunier PJ. hPTH 1–34 treatment of osteoporosis with added hormone replacement therapy: biochemical, kinetic and histological responses.Osteoporosis Int1991; I: 162–170.

    Article  Google Scholar 

  90. Marcus R, Butterfield G, Holloway L, Gilliland L, Baylink DJ, Hintz RL, Sherman BM. Effects of short term administration of recombinant human growth hormone to elderly people.J Clin Endocrinol Metab1990; 70: 519–527.

    Article  PubMed  CAS  Google Scholar 

  91. Mann DR, Rudman CG, Akinbami MA, Gould KG. Preservation of bone mass in hypogonadal female monkeys with recombinant human growth hormone administration.JClin Endocrinol Metab1992; 74: 1263–1269.

    Article  CAS  Google Scholar 

  92. Ljunghall S, Johansson AG, Burman P, Kampe O, Lindh E, Karlsson FA. Low plasma levels of insulin-like growth factor 1 (IGF-1) in male patients with idiopathic osteoporosis.JIntern Med1992; 232: 59–64.

    Article  CAS  Google Scholar 

  93. Rudman D, Feller AG, Hoskote S, Nagraj S, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE. Effects of human growth hormone in men over 60 years old.NEngl J Med1990; 323: 1–6.

    Article  CAS  Google Scholar 

  94. Marcus R, Holloway L, Butterfield G. Clinical uses of growth hormone in older people.JReprod Fertil Suppl1993; 46: 115–118.

    CAS  Google Scholar 

  95. Heaney RP, Baylink DJ, Johnston CJ, Melton LJI, Meunier PJ, Murray TM, Nagant de Deuxchaisnes C. Fluoride therapy for the vertebral crush fracture syndrome.Ann Int Med1989; 111(8): 678–680.

    PubMed  CAS  Google Scholar 

  96. Riggs BL, Hodgson SF, O’Fallon WM, Chao EYS, Wahner HW, Muhs JM, Cedel SL, Melton LJI. Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis.N Engl JMed1990; 322: 802–809.

    Article  CAS  Google Scholar 

  97. Danielson C, Lyon JL, Egger M, Goodenough GK. Hip fractures and fluoridation in Utah’s elderly population.JAMA1992; 268(6): 746–748.

    Article  PubMed  CAS  Google Scholar 

  98. Pak YC, Sakhaee K, Adams-Huet B, Piziak V, Peterson RD, Poindexter JR. Treatment of postmenopausal osteoporosis with slow-release sodium fluoride.Ann Int Med1995; 123: 401–408.

    PubMed  CAS  Google Scholar 

  99. Pak CYC, Sakhaee K, Piziak V, Peterson RD, Breslau NA, Boyd P, Poindexter JR, Herzog J, HeardSakhaee A, Haynes S, Adams-Huet B, Reisch JS. Slow-release sodium fluoride in the management of postmenopausal osteoporosis: a randomized controlled trial.Ann Int Med1994; 120: 625–632.

    PubMed  CAS  Google Scholar 

  100. Mamelle M, Meunier PJ, Dusan R, Guillaume M, Martin JL, Gaucher A, Prost A, Zeigler G. Risk-benefit ratio of sodium fluoride treatment in primary vertebral osteoporosis.Lancet 1988;II: 361–365.

    Article  Google Scholar 

  101. Pak CYC, Sakhaee K, Zerwekh JE, Parcel C, Peterson R, Johnson K. Safe and effective treatment of osteoporosis with intermittent slow release sodium fluoride: augmentation of vertebral bone mass and inhibition of fractures.J Clin Endocrino! Metab1989; 68: 150–159.

    Article  CAS  Google Scholar 

  102. Schulz EE, Engstrom H, Sauser DD, Baylink DJ. Osteoporosis: radiographic detection of fluoride-induced extra-axial bone formation.Radiology 1986;159: 457–462.

    PubMed  CAS  Google Scholar 

  103. Farley SMG, Wergedal JE, Smith LC, Lundy MW, Farley JR, Baylink DJ. Fluoride therapy for osteoporosis: characterization of the skeletal response by serial measurements of serum alkaline phosphatase activity.Metabolism1987; 36(3): 211–218.

    Article  PubMed  CAS  Google Scholar 

  104. El-Khoury GY, Moore TE, Albright JP, Huang HK, Martin RK. Sodium fluoride treatment of osteoporosis: radiologic findings.AJR1982; 139: 39–43.

    PubMed  CAS  Google Scholar 

  105. Jowsey J, Riggs BL, Kelly PJ, Hoffman DL. Effect of combined therapy with sodium fluoride, vitamin D and calcium in osteoporosis.Am JMed1972; 53: 43–49.

    CAS  Google Scholar 

  106. Meunier PJ, Galus K, Briancon D, Edouard C, Charhon SA. Treatment of idiopathic osteoporosis with sodium fluoride. Frances and Anthony D’Anna Memorial Symposium, Detroit, MI, 1983.

    Google Scholar 

  107. Inkovaara J, Heikinheimo R, Jarvinen K, Kasurinen U, Hanhijarvi H, Ilsalo E. Prophylactic fluoride treatment and aged bones.Br Med J 1975;3: 73–74.

    Article  PubMed  CAS  Google Scholar 

  108. Riggs BL, Hodgson SF, Hoffman DL, Kelly PJ, Johnson KA, Taves D. Treatment of primary osteoporosis with fluoride and calcium.JAMA1980; 243(5): 446–449.

    Article  PubMed  CAS  Google Scholar 

  109. Zerwekh JE, Antich PP, Sakhaee K, Gonzales J, Gottschalk F, Pak CYC. Assessment by reflection ultrasound method of the effect of intermittent slow-release sodium fluoride-calcium citrate therapy on material strength of bone.J Bone Miner Res1991; 6(3): 239–244.

    Article  PubMed  CAS  Google Scholar 

  110. Vermeulen A. Clinical review 24: androgens in the aging male.J Clin Endocrino! Metab1991; 73: 221–223.

    Article  CAS  Google Scholar 

  111. Vermeulen A, Kaufman JM. Editorial: role of the hypothalamo-pituitary function in the hypoandrogenism of healthy aging.J Clin Endocrino! Metab 1992;75: 704–706.

    Article  CAS  Google Scholar 

  112. Bardin CW, Swerdloff RS, Santen RJ. Special article-androgens: risk and benefits.JClin Endocrino! Metab1991; 73: 4–17.

    Article  CAS  Google Scholar 

  113. Orwoll ES, Klein RF. Osteoporosis in men.Endocr Rev1995; 16: 87–116.

    PubMed  CAS  Google Scholar 

  114. Murphy S, Khaw KT, Cassidy A, Compston JE. Sex hormones and bone mineral density in elderly men.Bone Miner1992; 20: 133–140.

    Article  Google Scholar 

  115. Johansson AG, Forslund A, Hambraeus L. Growth-hormone-dependent insulin-like growth factor binding protein is a major determinant of bone mineral density in healthy men.JBone Miner Res 1994;9: 915–921.

    Article  CAS  Google Scholar 

  116. Drinka PJ, Olson J, Bauwens S, Voeks S, Carlson I, Wilson M. Lack of association between free testosterone and bone density separate from age in elderly males.Calcif Tissue Int1993; 52: 67–69.

    Article  PubMed  CAS  Google Scholar 

  117. Meier DE, Orwoll ES, Keenan EJ, Fagerstrom RM. Marked decline in trabecular bone mineral content in healthy men with age: lack of association with sex steroid levels.JAGS1987; 35: 189–197.

    CAS  Google Scholar 

  118. Tenover JS. Effects of testosterone supplementation in the aging male.J Clin Endocrino! Metab1992; 75: 1092–1098.

    Article  CAS  Google Scholar 

  119. Clarke BL, Ebeling PR, Jones JD. Increased bone turnover with aging in men is not due to testosterone deficiency (abstract). Endocrine Society Program & Abstracts, Las Vegas, NV, 1993.

    Google Scholar 

  120. Bagatell CJ, Knopp RH, Vale WW, Rivier JE, Bremner WJ. Physiologic testosterone levels in normal men suppress high-density lipoprotein cholesterol levels.Ann Int Med1992; 116: 967–973.

    PubMed  CAS  Google Scholar 

  121. Thompson PD, Cullinane EM, Sady SP, Chenevert C, Saritelli AL, Sady MA. Contrasting effects of testosterone and stanozolol on serum lipoprotein levels.JAMA1989; 261: 1165–1168.

    Article  PubMed  CAS  Google Scholar 

  122. Jackson JA, Waxman J, Spiekerman M. Prostatic complications of testosterone replacement therapy.Arch Intern Med1989; 149: 2365–2366.

    Article  PubMed  CAS  Google Scholar 

  123. Arisaka O, Arisaka M. Effect of testosterone on radial bone mineral density in adolescent male hypogonadism.Acta Paediatr Scand1991; 80: 378–380.

    Article  PubMed  CAS  Google Scholar 

  124. Diamond T, Stiel D, Posen S. Effects of testosterone and venesection on spinal and peripheral bone mineral in six hypogonadal men with hemochromatosis.J Bone Miner Res1991; 6: 39–43.

    Article  PubMed  CAS  Google Scholar 

  125. Isaia G, Mussetta M, Pecchio F, Sciolla A, Di Stefano M, Molinatti GM. Effect of testosterone on bone in hypogonadal males.Maturitas 1992;15: 47–51.

    Article  PubMed  CAS  Google Scholar 

  126. Devogelaer JP, De Cooman S, de Deuxchaisnes CN. Low bone mass in hypogonadal males. Effect of testosterone substitution therapy, a densitometric study.Maturitas1992; 15: 17–23.

    Article  PubMed  CAS  Google Scholar 

  127. Finkelstein JS, Klibanski A, Neer RM, Doppelt SH, Rosenthal DI, Segre GV, Crowley WFJ. Increases in bone density during treatment of men with idiopathic hypogonadotropic hypogonadism.J Clin Endocrinol Metab1989; 69: 776–783.

    Article  PubMed  CAS  Google Scholar 

  128. Greenspan SL, Oppenheim DS, Klibanski A. Importance of gonadal steroids to bone mass in men with hyperprolactinemic hypogonadism.Ann Int Med1989; 110: 526–531.

    PubMed  CAS  Google Scholar 

  129. Baran DT, Bergfeld MA, Teitelbaum SL, Avioli LV. Effect of testosterone therapy on bone formation in an osteoporotic hypogonadalmale. Calcif Tissue Res 1978;26: 103–106.

    Article  PubMed  CAS  Google Scholar 

  130. Turner RT, Wakley GK, Hannon KS. Differential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats.J Orthopaed Res1990; 8: 612–617.

    Article  CAS  Google Scholar 

  131. Orwoll ES, Stribrska L, Ramsay EE, Keenan E. Androgen receptors in osteoblast-like cell lines.Calcif Tissue Int1991; 49: 182–187.

    Article  Google Scholar 

  132. Findlay JC, Place V, Snyder PJ. Treatment of primary hypogonadism in men by the transdermal administration of testosterone.J Clin Endocrinol Metab1989; 68: 369–373.

    Article  PubMed  CAS  Google Scholar 

  133. Findlay JC, Place VA, Snyder PJ. Transdermal delivery of testosterone.JClin Endocrinol Metab1987; 64: 266–268.

    Article  CAS  Google Scholar 

  134. Ahmed SR, Boucher AE, Manni A, Santen RJ, Bartholomew M, Demers LM. Transdermal testosterone therapy in the treatment of male hypogonadism.J Clin Endocrinol Metab`1988; 66: 546–551.

    Article  PubMed  CAS  Google Scholar 

  135. Vermeulen A, Deslypere JP. Long-term transdermal dihydrotestosterone therapy: effects on pituitary gonadal axis and plasma lipoproteins.Maturitas1985; 7: 182–287.

    Google Scholar 

  136. Wong FHW, Pun KK, Wang C. Loss of bone mass in patient with Klinefelter’s syndrome despite sufficient testosterone replacement.Osteoporosis Int1993; 7: 281–287.

    Google Scholar 

  137. Kubler A, Schulz G, Cordes U, Beyer J. Krause U. The influence of testosterone substitution on bone mineral density in patients with Klinefelter’s syndrome.Exp Clin Endocrinol1992; 100: 129–132.

    Article  PubMed  CAS  Google Scholar 

  138. Stepan JJ, Lachman M. Castrated men with bone loss: effect of calcitonin treatment on biochemical indices of bone remodeling.J Clin Endocrinol Metab1989; 69: 523–527.

    Article  PubMed  CAS  Google Scholar 

  139. Nordborg E, Hansson T, Jonson R. Glucocorticosteroid-induced osteoporosis in giant-cell arteritis (GCA).Scand JRheum1990; 85: 7.

    Google Scholar 

  140. Gluck OS, Murphy WA, Hahn Ti. Bone loss in adults receiving alternate day glucocorticoid therapy: a comparison with daily therapy.Arthritis Rheum1985; 24: 833–838.

    Google Scholar 

  141. Reid IR, Ibbertson HK. Calcium supplements in the prevention of steroid-induced osteoporosis.Am J Clin Nutr1986; 44: 287–290.

    PubMed  CAS  Google Scholar 

  142. Adams JS, Wahl TO, Luker BP. Effects of hydrochlorothiaize and dietary sodium restriction on calcium metabolism in corticosteroid treated patients.Metabolism1981; 30: 217–221.

    Article  PubMed  CAS  Google Scholar 

  143. Suzuki Y, Ichikawa Y, Saito E. Importance of increased urinary calcium excretion in the development of secondary hyperparathyroidism of patients under glucocorticoid therapy.Metabolism1983; 151–156.

    Google Scholar 

  144. Bikle DD, Halloran B, Fong L. Elevated 1,25-dihydroxyvitamin D levels in patients with chronic obstructive pulmonary disease treated with prednisone.J Clin Endocrinol Metab 1993;76: 456–461.

    Article  CAS  Google Scholar 

  145. Condon JR, Nassim JR, Dent CE. Possible prevention and treatment of steroid-induced osteoporosis.Postgrad Med J 1978;54: 249–252.

    Article  PubMed  CAS  Google Scholar 

  146. Braun JJ, Birkenhager-Frenkel DH, Reitveld AH. Influence of la-(OH)D3 administration on bone mineral metabolism in patients on chronic glucocorticoid treatment: a double-blind controlled study.Clin Endocrinol (Oxj)1983; 19: 265–273.

    Article  CAS  Google Scholar 

  147. Dykman TR, Haralson KM, Gluck OS. Effect of oral1,25-dihydroxyvitamin D and calcium on glucocorticoid-induced osteopenia in patients with rheumatic disease.Arthritis Rheum1984; 27: 1336–1341.

    Article  PubMed  CAS  Google Scholar 

  148. Bijlsma JW, Raymakers JA, Mosch C. Effect of oral calcium and vitamin Don glucocorticoid-induced osteopenia.Clin Exp Rheumatol1988; 6: 113–119.

    PubMed  CAS  Google Scholar 

  149. Rickers H, Deding A, Christiansen C. Mineral loss in cortical and trabecular bone during high-dose prednisone treatment.Calcif Tissue Int 1984;36: 269–273.

    Article  PubMed  CAS  Google Scholar 

  150. Sambrook P, Birmingahm J, Kelly P. Prevention of corticosteroid osteoporosis-a comparison of calcium, calcitriol and calcitonin.NEJM1993; 328: 1747–1752.

    Article  PubMed  CAS  Google Scholar 

  151. Schwartzman MS, Frank WA. Vitamin D toxicity complicating the treatment of senile, postmenopausal.Am JMed1987; 82: 224–230.

    CAS  Google Scholar 

  152. Meunier PJ, Birancon D, Chavassieux P. Treatment with fluoride: bone histomorphometric findings. In: Christiansen C, Johansen JS, Riis BJ, eds.Osteoporosis.Copenhagen, Denmark: Osteopress, 1987; pp. 824–828.

    Google Scholar 

  153. Montemurro L, Schiraldi G, Fraioli P, Tosi G, Riboldi A, Rizzato G. Prevention of corticosteroidinduced osteoporosis with salmon calcitonin in sarcoid patients.Calcif Tissue Int1991; 49: 71–76.

    Article  PubMed  CAS  Google Scholar 

  154. Luengo M, Picado C, Del Rio L. Treatment of steroid-induced osteoporosis with calcitonin in corticosteroid-dependent asthma.Am Rev Respir Dis1990; 142: 104–107.

    PubMed  CAS  Google Scholar 

  155. Nishioka T, Kurayama H, Yasuda T. Nasal administration of salmon calcitonin for prevention of glucocorticoid-induced osteoporosis in children with nephrosis.J Pediatr1991; 118: 703–707.

    Article  PubMed  CAS  Google Scholar 

  156. Reid JR, Heap SW, King AR. Two-year followup of bisphosphonate (APD) treatment in steroid osteoporosis.Lancet1988; ii : 1144.

    Google Scholar 

  157. Feitelberg S, Epstein S, Ismail F. Deranged bone mineral metabolism in chronic alcoholism.Metabolism1987; 36: 322–326.

    Article  PubMed  CAS  Google Scholar 

  158. Diamond T, Stiel D, Lunzer M, Wilkinson M, Posen S. Ethanol reduced bone formation and may cause osteoporosis.Am JMed1989; 86: 282–288.

    CAS  Google Scholar 

  159. Laitinen K, Lamberg-Allardt C, Tunninen R. Bone mineral density and abstention-induced changes in bone and mineral metabolism in noncirrhotic male alcoholics.Am JMed1992; 93: 642–650.

    CAS  Google Scholar 

  160. Jaouhari J, Schiele F, Pirollet P. Concentration and hydroxyapatite binding capacity of plasma osteocalcin in chronic alcoholic men: effect of a three-week withdrawal therapy.Bone Miner1993; 21: 171–178.

    Article  PubMed  CAS  Google Scholar 

  161. Peris P, Pares A, Guanabens N, Delrio L, Pons F, Deosaba MJM, Monegal A, Caballeria J, Rodes J, Munozgomez J. Bone mass improves in alcoholics after 2 years of abstinence.JBone Miner Res1994; 9: 1607–1612.

    Article  CAS  Google Scholar 

  162. Jung RT, Davie M, Hunter JO. Ultraviolet light: an effective treatment of osteomalacia in malabsorption.Br MedJ 1978; i: 1668–1669.

    Article  Google Scholar 

  163. Parfitt AM, Rao DS, Stanciu J, Villanueva AR, Kleerekoper M, Frame B. Irreversible bone loss in osteomalacia-comparison of radial photon absorptiometry with iliac bone histomorphometry during treatment.J Clin Invest1985; 76: 2403–2412.

    Article  PubMed  CAS  Google Scholar 

  164. McKenna MJ, Freaney R, Casey OM, Towers RP, Muldowney FP. Osteomalacia and osteoporosis: evaluation of a diagnostic index.J Clin Pathol1983; 36: 245–252.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Eric S. Orwoll MD
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  2. Robert F. Klein MD
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Editors and Affiliations

  1. Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor, Maine, USA

    Clifford J. Rosen MD

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Orwoll, E.S., Klein, R.F. (1996). Therapy for Osteoporosis in Men. In: Rosen, C.J. (eds) Osteoporosis. Current Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0221-9_21

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  • DOI: https://doi.org/10.1007/978-1-4612-0221-9_21

  • Publisher Name: Humana Press, Totowa, NJ

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