Abstract
At day 8.0 p.c., mouse Xin is strongly expressed in the outflow tract and sinus venosus of the developing heart tube. The mXin-positive cell layer in the developing sinus venosus is continuous with the mXin-negative endocardial layer of ventricle. At day 15 p.c., mXin messages are found in the myocardium but neither in endocardium nor in endocardial cushion. The Xin protein detected from adult rat or mouse heart or mouse skeletal muscle line C2C12 has molecular mass of 155 kd, whereas the size of the Xin protein from chicken heart is significantly larger. The expression of Xin protein in the differentiating C2C12 cells precedes the expression of skeletal muscle-specific tropomyosins. The Xin protein appears to be colocalized with N-cadherin and f3-catenin. In myogenesis, the Xin gene is downstream of Nkx2. 5 and MEF-2c and upstream of myofibrillar protein genes, such as myosin heavy chain and tropomyosins.
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Lin, J.JC., Wang, DZ., Reiter, R.S., Wang, Q., Lin, J.J.C., Williams, H.S. (2001). Differentially Expressed Genes and Cardiac Morphogenesis. In: Tomanek, R.J., Runyan, R.B. (eds) Formation of the Heart and Its Regulation. Cardiovascular Molecular Morphogenesis. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-0207-3_4
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