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Function and Biomechanics of Developing Cardiovascular Systems

  • Chapter
Formation of the Heart and Its Regulation

Part of the book series: Cardiovascular Molecular Morphogenesis ((CARDMM))

Abstract

Clinicians and scientists have searched for the mechanisms underlying normal and altered cardiovascular (CV) development for millennia. Scientific discovery regarding the CV system has occurred coincident with major advances in our understanding of CV anatomy, embryology, physiology, biomechanics, and, most recently, cellular and molecular biology. These investigations have occurred in a wide range of invertebrate and vertebrate species, representing the diverse adaptation of the CV system to environmental and life-cycle demands (Keller, 1997). The primary experimental model for the investigation of cardiac morphogenesis has been the chick embryo. Despite the small size of the embryonic chick heart, numerous investigators have developed experimental methods to accurately measure blood pressure, blood flow, chamber size, and altered cardiac function or form (Clark and Hu, 1982; Nakazawa et al, 1988; Keller, 1995). These investigations have described individual parameters and integrated measures of embryonic CV function comparable to the analysis of the mature heart (Table 13.1).

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Authors
  1. Bradley B. Keller
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Editors and Affiliations

  1. Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA, 52242-1109, USA

    Robert J. Tomanek

  2. Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ, 85724-5044, USA

    Raymond B. Runyan

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© 2001 Springer Science+Business Media New York

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Keller, B.B. (2001). Function and Biomechanics of Developing Cardiovascular Systems. In: Tomanek, R.J., Runyan, R.B. (eds) Formation of the Heart and Its Regulation. Cardiovascular Molecular Morphogenesis. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-0207-3_13

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  • DOI: https://doi.org/10.1007/978-1-4612-0207-3_13

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4612-6662-4

  • Online ISBN: 978-1-4612-0207-3

  • eBook Packages: Springer Book Archive

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