Abstract
Large-volume parenteral solutions were submitted to heat treatments after being inoculated with Bacillus stearothermophilus ATCC 7953 (T r = 121 °C) and Bacillus subtilis ATCC 9372 (T r = 104.5°C) spores. The average decimal reduction time for B. stearothermophilus ranged from a D 121°C value of 1.31 to 3.14 min, in glucophysiologic and Ringer’s solutions respectively. For B. subtilis, D 104.5°C value increased from 0.69 to 1.37 min, in Ringer’s (pH=5.91) and 50% glucose (pH 3.05) solutions respectively. The z value ranged from 7.95°C (20% mannitol solution) to 13.14°C (50% glucose solution), corresponding to an activation energy (Ea) of 81.48 and 49.30 kcal/ mol, respectively.
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Vessoni Penna, T.C., Marques, M., Machoshvili, I.A., Ishii, M. (2002). The Effect of Composition of Parenteral Solution on the Thermal Resistance of Bacillus stearothermophilus and Bacillus subtilis Spores. In: Finkelstein, M., McMillan, J.D., Davison, B.H. (eds) Biotechnology for Fuels and Chemicals. Applied Biochemistry and Biotechnology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0119-9_44
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DOI: https://doi.org/10.1007/978-1-4612-0119-9_44
Publisher Name: Humana Press, Totowa, NJ
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