The Role of Cell Adhesion Receptors in Vascular Development: An Overview

  • Paul Robson
  • Susan Pichla
  • Bin Zhou
  • H. Scott Baldwin
Part of the Cardiovascular Molecular Morphogenesis book series (CARDMM)


The establishment of the cardiovascular system represents an early, critical event essential for normal embryonic development. (Risau, 1997; Baldwin, 1998;Tallquist et al., 1999). Two different processes are thought to be involved in embryonic and extraembryonic blood vessel formation: angiogenesis, the budding and branching of vessels from preexisting vessels, and vasculogenesis, the de novo differentiation of endothelial cells from mesoderm and organization of endothelial progenitors into a primitive vascular plexus Fig5.1. This plexus then expands through sprouting angiogenesis, intussusceptive growth, and intercalation of new endothelial cells. Finally, this vascular plexus is remodeled by pruning, fusion, and regression of preexisting vessels into an arborized vascular tree composed of arteries, capillaries, and veins (reviewed in Carmeliet and Collen, 1999). Formation of the yolk sac circulation, differentiation of the endocardium of the heart, and development of larger vascular networks occur by vasculogenesis, while other organs, such as the brain and kidney, appear to be vascularized primarily by angiogenesis.


Vascular Development Dorsal Aorta Integrin Alpha Null Mutant Mouse Blood Island 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Paul Robson
  • Susan Pichla
  • Bin Zhou
  • H. Scott Baldwin

There are no affiliations available

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