Platelet Rich Plasma in Articular Cartilage Lesions

  • Elizaveta Kon
  • Giuseppe Filardo
  • Berardo Di Matteo
  • Giulia Venieri
  • Maurilio Marcacci
Chapter

Abstract

Cartilage tissue does not regenerate by itself and, when a lesion occurs, its biomechanical properties are impaired, with progressive tissue degeneration. Several novel approaches, both conservative and surgical, have been tested to improve cartilage healing potential. Among these options, the local administration of Platelet-rich Plasma (PRP) is increasingly being used to provide a biological stimulus to regeneration. Evidence to support its use has been gathered from the role played in tissue healing by several of the platelet derived growth factors. A critical review of the available literature was performed with regards to PRP use in surgical and conservative treatment of cartilage lesions or osteoarthritis (OA) in the main weight-bearing joints: knee, hip and ankle. At present, the lack of high quality trials does not permit conclusive indications for applying PRP in the management of cartilage pathology. The current evidence confirms the safety of the procedure and the beneficial effects achieved by this biological treatment but, when compared to other traditional treatments, the superiority of PRP has not been fully established.

Keywords

Dopamine Serotonin Polypeptide Osteoarthritis Histamine 

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Copyright information

© Springer-Verlag London 2016

Authors and Affiliations

  • Elizaveta Kon
    • 1
  • Giuseppe Filardo
    • 1
  • Berardo Di Matteo
    • 2
  • Giulia Venieri
    • 2
  • Maurilio Marcacci
    • 2
  1. 1.Nano-Biotechnology LaboratoryRizzoli Orthopaedic InstituteBolognaItaly
  2. 2.Biomechanics LaboratoryRizzoli Orthopaedic InstituteBolognaItaly

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