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Pediatric Drug Eruptions of the Skin

Abstract

Cutaneous adverse cutaneous drug reactions (CADRs) are common among the pediatric population. Although they are rarely considered serious, CADRs account for approximately 35 % of all adverse drug reactions. Because viral exanthems are extremely common in children, clinicians are often faced with a diagnostic dilemma when children are taking many medications and present with a rash. If a child is taking numerous medications, establishing causality to a specific drug can be multifaceted and difficult. We discuss the most common pediatric drug eruptions according to the pattern of the cutaneous eruption: urticarial, exanthematous, pustular, and vesicobullous. We also include a miscellaneous group for completeness. Proper management of a CADR requires an efficient method of accurately estimating the probability of a drug association, determining the likelihood of a relapse with drug re-challenge, and relaying this information to patients and their families. A hasty diagnosis of a drug “allergy” will follow a child through his or her life, and possibly increase their exposure to more toxic medications unnecessarily. Unless a re-challenge is performed, the vast majority of CADRs in children can only be considered as possibly associated with a drug.

Keywords

Pediatric cutaneous drug eruption Drug reaction Cutaneous adverse drug reactions (CADRs) Urticarial Exanthematous Pustular Vesicobullous 

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Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  1. 1.PathologyUniversity of VermontBurlingtonUSA

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