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Cutaneous Drug Eruptions pp 235–247Cite as

Drug Reactions in the Nail in Cutaneous Drug Eruptions

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Abstract

Nail disorders can be challenging to diagnose for clinicians and difficult to endure for patients. They encompass a wide variety of pathology and sequelae from direct trauma causing cosmetic deformity and pain, to diffuse changes that may herald an underlying systemic disease, a toxic exposure, or the side effect of a drug. In the setting of drug side effects, cessation of the offending agent may sometimes be curative, however, it may not always be feasible or warranted, such as in the case of chemotherapeutics. Clinicians, who can link nail changes and the mechanism of action/targets in drugs to the appropriate affected components of the nail apparatus, are at an advantage for timely detection and intervention. Nail changes can result from destruction of the epithelium, changes in vascularity, changes in permeability, toxicities, and/or pigmentation. In this chapter we review the reactions manifested by nails in conjunction with potential culpable drugs.

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Author information

Authors and Affiliations

  1. Department of Pathology, Tulane University, 1430 Tulane Ave, New Orleans, LA, 70112, USA

    John P. Scopetta MD

  2. Department of Dermatopathology, Managing Director, SkinPath Solutions Smyrna, GA, USA

    Dipti Anand MD

  3. Department of Dermatology and Dermatopathology, Compass Dermatopathology, San Diego, CA, USA

    Antoanella Calame MD

  4. Department of Dermatology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA

    A. Shadi Kourosh MD

Authors
  1. John P. Scopetta MD
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  2. Dipti Anand MD
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  3. Antoanella Calame MD
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  4. A. Shadi Kourosh MD
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Corresponding author

Correspondence to John P. Scopetta MD .

Editor information

Editors and Affiliations

  1. Kansas City, Kansas, USA

    John C. Hall

  2. Miraca Life Sciences, Irving, Texas, USA

    Brian J. Hall

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© 2015 Springer-Verlag London

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Scopetta, J.P., Anand, D., Calame, A., Kourosh, A.S. (2015). Drug Reactions in the Nail in Cutaneous Drug Eruptions. In: Hall, J., Hall, B. (eds) Cutaneous Drug Eruptions. Springer, London. https://doi.org/10.1007/978-1-4471-6729-7_22

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  • DOI: https://doi.org/10.1007/978-1-4471-6729-7_22

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-6728-0

  • Online ISBN: 978-1-4471-6729-7

  • eBook Packages: MedicineMedicine (R0)

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