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The Epigenome and Aging

  • Chapter
Environmental Epigenetics

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

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Abstract

The epigenetics of aging is a relatively new field. Global DNA methylation has been examined for some time; however, only recently have age-related differentially methylated regions been elaborated. These regions encompass genes that in some cases interact with longevity and disease-associated genes. Histone modifications have now become of interest in aging studies. Model organisms have provided substantial evidence that some of the enzymes that are involved in histone modifications play a role in longevity, and direct evidence of such a role for one of the sirtuins has been gathered in mice. A number of studies examining expression of microRNA during aging in various organisms, including human, point to the possibility that these gene regulatory molecules may also be involved in aging. A recent study of one such microRNA in mice substantiates such a role in cardiac aging. All of these epigenetic mechanisms are responsive to environmental and lifestyle factors. Thus, the groundwork has been laid for an understanding of the interface between the genome and the environment that epigenetic mechanisms provide.

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Acknowledgments

Research in our laboratory is supported by grants from the National Institute on Aging and from the National Institute of General Medical Sciences.

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Authors and Affiliations

  1. Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Ave., SL-12, New Orleans, LA, 70112, USA

    Sangkyu Kim & S. Michal Jazwinski

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  1. Sangkyu Kim
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  2. S. Michal Jazwinski
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Correspondence to S. Michal Jazwinski .

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Editors and Affiliations

  1. Division of Cancer Control and Population Sciences, Epidemiology and Genomic Research Program, Modifiable Risk Factors Branch, National Cancer Institute, Rockville, Maryland, USA

    L. Joseph Su

  2. Research Participation Program at Center for Biologics Evaluation and Research at the U.S. Food and Drug Administration, Oak Ridge Institute for Science and Education, Oak Ridge Associate University (ORAU), Oak Ridge, Tennessee, Tennessee, USA

    Tung-chin Chiang

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Kim, S., Jazwinski, S.M. (2015). The Epigenome and Aging. In: Su, L., Chiang, Tc. (eds) Environmental Epigenetics. Molecular and Integrative Toxicology. Springer, London. https://doi.org/10.1007/978-1-4471-6678-8_8

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