Skip to main content

Clinical Features

  • Chapter
  • First Online:
Inflammatory Arthritis in Clinical Practice

Abstract

The hallmark of the inflammatory arthropathies is joint inflammation, characterised by joint pain and swelling. Different disease types affect different joints. RA classically affects the peripheral small joints in a symmetrical fashion. By contrast the seronegative spondyloarthropathies tend to affect the spine and peripheral large joints in an asymmetrical fashion. Extra-articular features are common in all forms of inflammatory arthritis. In RA almost any body system can be affected, with manifestations ranging from rheumatoid nodules to mononeuritis multiplex. The classical extra-articular manifestation of the seronegative spondyloarthropathies is anterior uveitis. This chapter will discuss the clinical manifestations of the inflammatory arthropathies, spanning their articular and extra-articular features.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. van der Heijde DM, van ‘t Hof MA, van Riel PL, Theunisse LA, Lubberts EW, van Leeuwen MA, et al. Judging disease activity in clinical practice in rheumatoid arthritis: first step in the development of a disease activity score. Ann Rheum Dis. 1990;49:916–20.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010;376:1094–108.

    Article  PubMed  Google Scholar 

  3. Klarenbeek NB, Kerstens PJ, Huizinga TW, Dijkmans BA, Allaart CF. Recent advances in the management of rheumatoid arthritis. BMJ. 2010;341:c6942.

    Article  PubMed  Google Scholar 

  4. Helliwell PS, Hetthen J, Sokoll K, Green M, Marchesoni A, Lubrano E, et al. Joint symmetry in early and late rheumatoid and psoriatic arthritis: comparison with a mathematical model. Arthritis Rheum. 2000;43:865–71.

    Article  CAS  PubMed  Google Scholar 

  5. Dhir V, Aggarwal A. Psoriatic arthritis: a critical review. Clin Rev Allergy Immunol. 2013;44:141–8.

    Article  PubMed  Google Scholar 

  6. McGonagle D. Enthesitis: an autoinflammatory lesion linking nail and joint involvement in psoriatic disease. J Eur Acad Dermatol Venereol. 2009;23 Suppl 1:9–13.

    Article  CAS  PubMed  Google Scholar 

  7. Zochling J, Smith EU. Seronegative spondyloarthritis. Best Pract Res Clin Rheumatol. 2010;24:747–56.

    Article  PubMed  Google Scholar 

  8. Joaquim AF, Appenzeller S. Cervical spine involvement in rheumatoid arthritis – a systematic review. Autoimmun Rev. 2014;13:1195–202.

    Article  PubMed  Google Scholar 

  9. Symmons DP, Silman AJ. Aspects of early arthritis. What determines the evolution of early undifferentiated arthritis and rheumatoid arthritis? An update from the Norfolk Arthritis Register. Arthritis Res Ther. 2006;8:214.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Emad Y, Anbar A, Abo-Elyoun I, El-Shaarawy N, Al-Hanafi H, Darwish H, et al. In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1 year of follow-up. Clin Rheumatol. 2014;33:791–7.

    Article  PubMed  Google Scholar 

  11. Scott DL, Steer S. The course of established rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2007;21:943–67.

    Article  PubMed  Google Scholar 

  12. Young A, Koduri G. Extra-articular manifestations and complications of rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2007;21:907–27.

    Article  PubMed  Google Scholar 

  13. Doyle TJ, Lee JS, Dellaripa PF, Lederer JA, Matteson EL, Fischer A, et al. A roadmap to promote clinical and translational research in rheumatoid arthritis-associated interstitial lung disease. Chest. 2014;145:454–63.

    Article  PubMed  Google Scholar 

  14. Sen D, Gonzalez-Mayda M, Brasington Jr RD. Cardiovascular disease in rheumatoid arthritis. Rheum Dis Clin North Am. 2014;40:27–49.

    Article  PubMed  Google Scholar 

  15. van der Horst-Bruinsma IE, Nurmohamed MT, Landewe RB. Comorbidities in patients with spondyloarthritis. Rheum Dis Clin North Am. 2012;38:523–38.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag London

About this chapter

Cite this chapter

Scott, I.C., Galloway, J.B., Scott, D.L. (2015). Clinical Features. In: Inflammatory Arthritis in Clinical Practice. Springer, London. https://doi.org/10.1007/978-1-4471-6648-1_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-6648-1_3

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-6647-4

  • Online ISBN: 978-1-4471-6648-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics